| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Migraine without Aura | D020326 | 1 associated lipids |
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kono N et al. | Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. | 2008 | J. Biol. Chem. | pmid:18024956 |
| Schaefer MB et al. | Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | 2008 | Eur. Respir. J. | pmid:18653653 |
| Samanta U and Bahnson BJ | Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. | 2008 | J. Biol. Chem. | pmid:18784071 |
| Beuk RJ et al. | Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. | 2008 | Br J Surg | pmid:18720462 |
| Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
| Fang H et al. | Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. | 2008 | Microbiol. Immunol. | pmid:18667035 |
| Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
| Kuliszkiewicz-Janus M et al. | Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. | 2008 | Cell. Mol. Biol. Lett. | pmid:17952375 |
| Bélanger C et al. | Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. | 2008 | Immunology | pmid:18217950 |
| Leong HS et al. | Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factor. | 2008 | J. Leukoc. Biol. | pmid:17974709 |
| Kostopanagiotou G et al. | Acute lung injury in a rat model of intestinal ischemia-reperfusion: the potential time depended role of phospholipases A(2). | 2008 | J. Surg. Res. | pmid:17981297 |
| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Ogura M et al. | Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. | 2008 | Auris Nasus Larynx | pmid:17997066 |
| Figueiredo MB et al. | Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments. | 2008 | J. Insect Physiol. | pmid:18036540 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| Gountopoulou A et al. | TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. | 2008 | Cytokine | pmid:18180165 |
| Kwasniewski FH et al. | Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | 2008 | Int. Immunopharmacol. | pmid:18182253 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Zhang Q et al. | UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system. | 2008 | J. Invest. Dermatol. | pmid:18200048 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Nomura DK et al. | Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18164358 |
| O' Meara CM et al. | Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. | 2008 | Theriogenology | pmid:18248736 |
| Sakellariou M et al. | Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18248752 |
| Chu W et al. | Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: inhibitory effect of flavonoids on PAF-induced Ca2+ overload. | 2008 | Phytother Res | pmid:17724771 |
| Morita K et al. | Glycinergic mediation of tactile allodynia induced by platelet-activating factor (PAF) through glutamate-NO-cyclic GMP signalling in spinal cord in mice. | 2008 | Pain | pmid:18353555 |
| Simonenko VB et al. | [Losartan for the correction of thrombocyte activity in patients suffering from arterial hypertension with metabolic syndrome]. | 2008 | Klin Med (Mosk) | pmid:18326282 |
| Harayama T et al. | Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. | 2008 | J. Biol. Chem. | pmid:18285344 |
| Mizutani T et al. | Genuine functions of P-glycoprotein (ABCB1). | 2008 | Curr. Drug Metab. | pmid:18288958 |
| Fukunaga A et al. | Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. | 2008 | J. Immunol. | pmid:18292528 |
| van Zoelen MA et al. | Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. | 2008 | J. Immunol. | pmid:18292561 |
| Knapp S et al. | Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. | 2008 | J. Immunol. | pmid:18292574 |
| Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
| Claud EC et al. | Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18339705 |
| Kudriavtseva IuA et al. | [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. | 2008 | Angiol Sosud Khir | pmid:19156039 |
| Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
| Tsujimura Y et al. | Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. | 2008 | Immunity | pmid:18342553 |
| Patel MI et al. | The arachidonic acid pathway and its role in prostate cancer development and progression. | 2008 | J. Urol. | pmid:18343442 |
| Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
| Berry KA et al. | Effects of acrolein on leukotriene biosynthesis in human neutrophils. | 2008 | Chem. Res. Toxicol. | pmid:19548361 |
| Lu J et al. | Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Akt-mediated apoptosis in intestinal epithelial cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18356536 |
| Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery. | 2008 | J. Lipid Res. | pmid:18587071 |
| Ryan SD et al. | Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. | 2008 | J. Lipid Res. | pmid:18550892 |
| Jiang Y et al. | Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18515648 |
| LeBlanc CJ et al. | Effects of dietary supplementation with fish oil on in vivo production of inflammatory mediators in clinically normal dogs. | 2008 | Am. J. Vet. Res. | pmid:18380580 |
| Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
| McLaughlin NJ et al. | Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. | 2008 | J. Immunol. | pmid:18523285 |
| Felfernig M et al. | Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. | 2008 | J R Nav Med Serv | pmid:18524134 |
| Tsoupras AB et al. | Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? | 2008 | AIDS Res. Hum. Retroviruses | pmid:18620493 |
| Corl CM et al. | Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. | 2008 | J. Dairy Sci. | pmid:18650283 |