| MeSH term | MeSH ID | Detail |
|---|---|---|
| Migraine without Aura | D020326 | 1 associated lipids |
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Terashita Z et al. | Protective effects of a platelet activating factor (PAF) antagonist and its combined treatment with prostaglandin (PG) E1 in traumatic shock. | 1988 | J. Cardiovasc. Pharmacol. | pmid:2468048 |
| Elstad MR et al. | Synthesis and release of platelet-activating factor by stimulated human mononuclear phagocytes. | 1988 | J. Immunol. | pmid:3126231 |
| Hanss M and Dechavanne M | 48740 RP, an antagonist of PAF, does not affect human plasma fibrinolysis before and after venous occlusion. | 1988 | Thromb. Res. | pmid:3126559 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether. I. Effect of paf-acether on CD4+ cell proliferation. | 1988 | J. Immunol. | pmid:2961808 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Winkler JD et al. | Leukotriene B4-induced homologous desensitization of calcium mobilization and phosphoinositide metabolism in U-937 cells. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2839662 |
| Croft KD et al. | Effect of dietary fish oils on the formation of leukotriene B4 and B5, thromboxane and platelet activating factor by rat leukocytes. | 1988 | Clin. Exp. Pharmacol. Physiol. | pmid:2856061 |
| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, of antagonists of the eicosanoids and of PAF on mortality assayed in three biochemically characterized shock models. | 1988 | Biomed. Biochim. Acta | pmid:3150272 |
| Powling MJ and Hardisty RM | Potentiation by adrenaline of Ca2+ influx and mobilization in stimulated human platelets: dissociation from thromboxane generation and aggregation. | 1988 | Thromb. Haemost. | pmid:3388294 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
| Ward SG and Westwick J | Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells. | 1988 | Br. J. Pharmacol. | pmid:3390650 |
| Demopoulos CA et al. | Abnormal platelet response to PAF and ADP in beta-thalassaemia. | 1988 | Int. J. Biochem. | pmid:3391336 |
| Christman BW et al. | Role of circulating platelets and granulocytes in PAF-induced pulmonary dysfunction in awake sheep. | 1988 | J. Appl. Physiol. | pmid:3391901 |
| Greenberg S et al. | Extracellular nucleotides mediate Ca2+ fluxes in J774 macrophages by two distinct mechanisms. | 1988 | J. Biol. Chem. | pmid:3392016 |
| Wallace JL and MacNaughton WK | Gastrointestinal damage induced by platelet-activating factor: role of leukotrienes. | 1988 | Eur. J. Pharmacol. | pmid:2843390 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. | 1988 | J. Allergy Clin. Immunol. | pmid:3403863 |
| Koenderman L et al. | An improved method for the isolation of eosinophilic granulocytes from peripheral blood of normal individuals. | 1988 | J. Leukoc. Biol. | pmid:3404069 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Coyle AJ et al. | The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation. | 1988 | Eur. J. Pharmacol. | pmid:3383997 |
| Tokumura A et al. | Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. | 1988 | Eur. J. Pharmacol. | pmid:3384001 |
| Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
| Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
| Makino S | [Platelet activating factor in allergic reaction]. | 1988 | Arerugi | pmid:3052368 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Wasserman SI | Platelet-activating factor as a mediator of bronchial asthma. | 1988 | Hosp. Pract. (Off. Ed.) | pmid:3053741 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Keery RJ and Lumley P | AH6809, a prostaglandin DP-receptor blocking drug on human platelets. | 1988 | Br. J. Pharmacol. | pmid:2460179 |
| Foegh ML | Eicosanoids and platelet activating factor mechanisms in organ rejection. | 1988 | Transplant. Proc. | pmid:3059615 |
| Roberts NM et al. | Effect of a PAF antagonist, BN52063, on PAF-induced bronchoconstriction in normal subjects. | 1988 | Br J Clin Pharmacol | pmid:3203062 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Freitas JC et al. | Inhibition of platelet aggregation by manoalide: preliminary results. | 1988 | Braz. J. Med. Biol. Res. | pmid:3203166 |
| Pai JK et al. | Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes. | 1988 | J. Biol. Chem. | pmid:3165977 |
| Collier M et al. | Biochemical and pharmacological characterization of human embryo-derived platelet activating factor. | 1988 | Hum. Reprod. | pmid:3204154 |
| Armstead WM et al. | Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs. | 1988 | Circ. Res. | pmid:3335052 |
| Weisman SM et al. | Differential effect of platelet-activating factor (PAF) receptor antagonists on peptide and PAF-stimulated prostaglandin release in unilateral ureteral obstruction. | 1988 | Biochem. Pharmacol. | pmid:2840083 |
| Lee TC et al. | Formation of 1-alkyl-2-acetyl-sn-glycerols via the de novo biosynthetic pathway for platelet-activating factor. Characterization of 1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphohydrolase in rat spleens. | 1988 | J. Biol. Chem. | pmid:2828351 |
| Nieto ML et al. | Biosynthesis of platelet-activating factor in human polymorphonuclear leukocytes. Involvement of the cholinephosphotransferase pathway in response to the phorbol esters. | 1988 | J. Biol. Chem. | pmid:2828363 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Hwang SB | Identification of a second putative receptor of platelet-activating factor from human polymorphonuclear leukocytes. | 1988 | J. Biol. Chem. | pmid:2830276 |
| Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
| Marquis O et al. | [3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2831350 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Dillon PK et al. | Vasoconstrictor effects of platelet-activating factor in the hamster cheek pouch microcirculation: dose-related relations and pathways of action. | 1988 | Circ. Res. | pmid:2832096 |
| McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
| Abraham WM and Wanner A | Inflammatory mediators of asthma. | 1988 | Pediatr. Pulmonol. | pmid:2455882 |
| Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
| Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
| Hsueh W et al. | Sequential release of leukotrienes and norepinephrine in rat bowel after platelet-activating factor. A mechanistic study of platelet-activating factor-induced bowel necrosis. | 1988 | Gastroenterology | pmid:3360262 |
| Hasegawa T and Nakajima S | [Recent topics on platelet-activating-factor (PAF)]. | 1988 | Nippon Ika Daigaku Zasshi | pmid:3360909 |
| Chau LY and Jii YJ | Characterization of 3H-labelled platelet activating factor receptor complex solubilized from rabbit platelet membranes. | 1988 | Biochim. Biophys. Acta | pmid:2838093 |
| Thelen M et al. | Activation of monocytes by interferon-gamma has no effect on the level or affinity of the nicotinamide adenine dinucleotide-phosphate oxidase and on agonist-dependent superoxide formation. | 1988 | J. Clin. Invest. | pmid:2838524 |
| Errasfa M et al. | Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2968795 |
| Eliakim R et al. | Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. | 1988 | Gastroenterology | pmid:2901995 |
| Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
| Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
| Royall JA and Levin DL | Adult respiratory distress syndrome in pediatric patients. I. Clinical aspects, pathophysiology, pathology, and mechanisms of lung injury. | 1988 | J. Pediatr. | pmid:3276861 |
| Vanhoutte PM | Platelets, endothelium and blood vessel wall. | 1988 | Experientia | pmid:3278917 |
| Lellouch-Tubiana A et al. | Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. | 1988 | Am. Rev. Respir. Dis. | pmid:3281530 |
| Chung KF and Barnes PJ | PAF antagonists. Their potential therapeutic role in asthma. | 1988 | Drugs | pmid:3281823 |
| Rubin RM and Rosenbaum JT | A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3260779 |
| Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
| Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |
| Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
| Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
| Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
| Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
| Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
| Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
| Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
| Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
| Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
| Morimoto H et al. | Plasma extravasation by chemical mediators in rat skin and trachea: a role of neurogenic agents on tracheal edema formation. | 1989 | Jpn. J. Pharmacol. | pmid:2473234 |
| Block LH et al. | Platelet-activating factor (PAF)-dependent biochemical, morphologic, and physiologic responses of human platelets: demonstration of translocation of protein kinase C associated with protein phosphorylation. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2624764 |
| Record M et al. | Subcellular localization of phospholipids and enzymes involved in PAF-acether metabolism. | 1989 | J. Cell. Biochem. | pmid:2506197 |
| Ryan JP et al. | Platelet activating factor (PAF) production by mouse embryos in vitro and its effect on embryonic metabolism. | 1989 | J. Cell. Biochem. | pmid:2506198 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| McColl SR et al. | Involvement of guanine nucleotide binding proteins in neutrophil activation and priming by GM-CSF. | 1989 | Blood | pmid:2537115 |
| Barzaghi G et al. | Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2537401 |
| Redkar-Brown DG and Aharony D | Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615. | 1989 | Eur. J. Pharmacol. | pmid:2767127 |
| Burstein SH et al. | Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553925 |
| Mencia-Huerta JM et al. | Effect of long-term administration of platelet-activating factor on pulmonary responsiveness and morphology in the guinea pig. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2707878 |
| Ricker DD et al. | The effects of platelet-activating factor on the motility of human spermatozoa. | 1989 | Fertil. Steril. | pmid:2806605 |
| Guinot P et al. | Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. | 1989 | Haemostasis | pmid:2807039 |
| Harper MJ | Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction? | 1989 | Biol. Reprod. | pmid:2669984 |
| Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
| Oda M et al. | [Platelet-activating factor producing cell--target cell interactions]. | 1989 | Rinsho Byori | pmid:2754814 |
| Makino S | [Platelet-activating factor and disease]. | 1989 | Kokyu To Junkan | pmid:2657915 |
| De Vos C et al. | Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2523357 |
| Hemmendinger S et al. | Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. | 1989 | J. Allergy Clin. Immunol. | pmid:2523922 |
| Cucala M et al. | CNS effects of platelet-activating factor on the rat stomach. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2725123 |
| Schirmer WJ et al. | Systemic and renal hemodynamic response to platelet activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2726980 |
| Hatakeyama K et al. | Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595312 |
| GarcÃa-Sáinz JA | Intercellular communication within the liver has clinical implications. | 1989 | Trends Pharmacol. Sci. | pmid:2595791 |
| Thierry A et al. | Presence of specific platelet-activating factor binding sites in the rat retina. | 1989 | Eur. J. Pharmacol. | pmid:2545464 |
| Marquis O et al. | Evidence for the existence and ionic modulation of platelet-activating factor receptors mediating degranulatory responses in human polymorphonuclear leukocytes. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2545861 |