| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bertrand C et al. | Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models. | 1990 | Agents Actions Suppl. | pmid:2080755 |
| Tsunoda H et al. | Effects of a novel PAF antagonist, E6123, on PAF-induced biological responses. | 1990 | Agents Actions Suppl. | pmid:2080757 |
| Sakuma Y et al. | Effects of a novel PAF antagonist, E6123, on passive anaphylaxis. | 1990 | Agents Actions Suppl. | pmid:2080758 |
| Rihoux JP | The inhibiting effect of cetirizine 2 HC1 on eosinophil migration and its link to H1 blockade. | 1991 | Agents Actions Suppl. | pmid:1675836 |
| Kurosawa M | Effect of platelet activating factor on histamine release from rat mast cells. | 1987 | Agents Actions Suppl. | pmid:2445185 |
| Goldie RG et al. | PAF receptors in guinea-pig and human lung. | 1990 | Agents Actions Suppl. | pmid:1964365 |
| Parnham MJ et al. | Regulation of the oxidative burst of macrophages by lipid mediators. | 1984 | Agents Actions Suppl. | pmid:6433680 |
| Schrör K and Felsch A | Ramiprilat prevents PAF-induced myocellular and endothelial injury in a neutrophil-perfused heart preparation. | 1992 | Agents Actions Suppl. | pmid:1334351 |
| Soloviev A and Braquet P | The similarity in action of hypoxia and platelet-activating factor on smooth muscle cells of coronary arteries: possible explanation for hypoxic coronary spasm development. | 1995 | Agents Actions Suppl. | pmid:7717190 |
| Anderson GP and Fennessy MR | Lipoxygenase metabolites as mediators of platelet activating factor-induced increased airways responsiveness to histamine in the guinea-pig. | 1988 | Agents Actions Suppl. | pmid:3140616 |
| Muirhead EE | Vasodepressor lipid of the renomedullary interstitial cells of the renal papilla is a prohormone activated by the liver. | 1987 | Agents Actions Suppl. | pmid:3324720 |
| Barnes PJ | New concepts in the pathogenesis of bronchial hyperresponsiveness. | 1987 | Agents Actions Suppl. | pmid:3314413 |
| Mustard JF et al. | Platelet activation--an overview. | 1987 | Agents Actions Suppl. | pmid:3314414 |
| Page CP and Robertson DN | Properties of PAF relevant to asthma. | 1987 | Agents Actions Suppl. | pmid:3314416 |
| Morley J | PAF and airway hyperreactivity; prospects for novel prophylactic anti-asthma drugs. | 1987 | Agents Actions Suppl. | pmid:3314417 |
| Braquet P et al. | The role of PAF-acether in anaphylaxis demonstrated with the use of the antagonist BN 52021. | 1987 | Agents Actions Suppl. | pmid:3314418 |
| Vargaftig BB | Phospholipids, particularly platelet-activating factor (PAF-acether), in experimental bronchoconstriction. | 1983 | Agents Actions Suppl. | pmid:6575594 |
| Page CP et al. | PAF-acether: a putative mediator of asthma and inflammation. | 1983 | Agents Actions Suppl. | pmid:6575595 |
| Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
| Stenzel H et al. | Effect of the PAF-antagonist SRI 63-441 on the allergic reaction in awake dogs with natural asthma. | 1987 | Agents Actions Suppl. | pmid:2823582 |
| O'Flaherty JT and Wykle RL | Metabolic origin and fate of platelet-activating factor. | 1987 | Agents Actions Suppl. | pmid:2823583 |
| Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
| PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986. | 1987 | Agents Actions Suppl. | pmid:3478993 | |
| Farr RS et al. | Platelet abnormalities in asthma--do they exist in humans? | 1987 | Agents Actions Suppl. | pmid:3478994 |
| Menz G et al. | Lack of PAF release in extrinsic asthma. | 1987 | Agents Actions Suppl. | pmid:3478995 |
| Szczeklik A et al. | Bleeding time and PAF-acether-induced platelet aggregation in atopy. | 1987 | Agents Actions Suppl. | pmid:3478996 |
| Schmitz-Schumann M et al. | Evidence of PAF release and platelet activation in analgesics-asthma-syndrome. | 1987 | Agents Actions Suppl. | pmid:3478999 |
| Guinot P et al. | Effects of BN 52063 on PAF-acether induced weal and flare in man. | 1987 | Agents Actions Suppl. | pmid:3479000 |
| Lang M et al. | Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | Agents Actions Suppl. | pmid:3479001 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Doyle SA et al. | Further studies on the antinociceptive effects of delta 6-THC-7-oic acid. | 1990 | Agents Actions | pmid:2178317 |
| Archer CB et al. | Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. | 1985 | Agents Actions | pmid:3923788 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Boughton-Smith NK et al. | Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. | 1992 | Agents Actions | pmid:1279960 |
| Will PC et al. | Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. | 1991 | Agents Actions | pmid:1793026 |
| Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |
| Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
| Heller R et al. | S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells. | 1993 | Agents Actions | pmid:7517616 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
| Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
| Page CP et al. | Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. | 1985 | Agents Actions | pmid:4003196 |
| Spicer BA et al. | An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. | 1985 | Agents Actions | pmid:4003197 |
| Camussi G et al. | Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). | 1981 | Agents Actions | pmid:7041569 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Tubaro E et al. | In vitro and in vivo impact of a new glycosphingolipid on neutrophils. | 1994 | Agents Actions | pmid:7879694 |
| Canale P et al. | TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock. | 1994 | Agents Actions | pmid:7879698 |