| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agwu DE et al. | Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2466463 |
| Wainwright CL et al. | The effects of PAF antagonists on arrhythmias and platelets during acute myocardial ischaemia and reperfusion. | 1989 | Eur. Heart J. | pmid:2468494 |
| Lippe IT and Holzer P | The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle. | 1989 | Eur. J. Pharmacol. | pmid:2468509 |
| VornovitskiÄ EG et al. | [Interactions of PAF and its antagonists in the guinea pig atrial myocardium]. | 1989 | Biull Eksp Biol Med | pmid:2804312 |
| Bruijnzeel PL et al. | Inhibition of platelet-activating factor- and zymosan-activated serum-induced chemotaxis of human neutrophils by nedocromil sodium, BN 52021 and sodium cromoglycate. | 1989 | Br. J. Pharmacol. | pmid:2551444 |
| Seifert R et al. | Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells. | 1989 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2552328 |
| Dent G et al. | [3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung. | 1989 | Eur. J. Pharmacol. | pmid:2553451 |
| Slattery CW and Beaumont DO | Sheep platelets as a model for human platelets: evidence for specific PAF (platelet activating factor) receptors. | 1989 | Thromb. Res. | pmid:2554526 |
| Kester M et al. | Beta-adrenergic inhibition of AGEPC-stimulated Na+/Ca2+ exchange and AGEPC-induced platelet activation. | 1989 | Biochim. Biophys. Acta | pmid:2554977 |
| Korth R et al. | Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells. | 1989 | Br. J. Pharmacol. | pmid:2555017 |
| Gerzer R et al. | Inhibition of platelet activating factor-induced platelet aggregation by molsidomine, SIN-1, and nitrates in vitro and ex vivo. | 1989 | J. Cardiovasc. Pharmacol. | pmid:2484688 |
| Muirhead EE et al. | Biologic contrasts between medullipin I and vasoactive glyceryl compounds. | 1989 | Am. J. Med. Sci. | pmid:2764021 |
| Goldstein SM et al. | Mast cell and eosinophil mediated damage in bullous pemphigoid. | 1989 | Immunol. Ser. | pmid:2484955 |
| Chao W et al. | Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187. | 1989 | Biochem. J. | pmid:2494988 |
| Stengel PW and Silbaugh SA | Reversal of A23187-induced airway constriction in the guinea pig. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2495351 |
| Wey HE | Phorbol diester enhances calcium ionophore A23187-induced [3H]acetate incorporation into platelet-activating factor in murine macrophages: predominant incorporation into 1-O-acyl-2-acetyl-sn-glycero-3-phosphocholine. | 1989 | J. Cell. Biochem. | pmid:2496135 |
| Shalit M et al. | Late appearance of phospholipid platelet-activating factor and leukotriene B4 in human skin after repeated antigen challenge. | 1989 | J. Allergy Clin. Immunol. | pmid:2538500 |
| Stewart AG et al. | Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells. | 1989 | Br. J. Pharmacol. | pmid:2497920 |
| Xiao HS | [Relation of blood platelets and the cause of bronchial asthma]. | 1989 | Zhong Xi Yi Jie He Za Zhi | pmid:2532572 |
| Warren JS et al. | Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. | 1989 | J. Clin. Invest. | pmid:2536403 |
| Kurihara K et al. | Inhibition of platelet-activating factor (PAF)-induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist, BN 52021. | 1989 | J. Allergy Clin. Immunol. | pmid:2536413 |
| Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
| Hwang SB et al. | Characterization of platelet-activating factor (PAF) receptor by specific binding of [3H]L-659,989, a PAF receptor antagonist, to rabbit platelet membranes: possible multiple conformational states of a single type of PAF receptors. | 1989 | Mol. Pharmacol. | pmid:2536468 |
| Morley J | Asthma pharmacology: industrial/clinical interface. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2693363 |
| Etienne A et al. | Protective effect of the PAF-antagonist BN 52021 on several models of gastro-intestinal mucosal damage in rats. | 1989 | Int J Tissue React | pmid:2693389 |
| Schlondorff D | Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. | 1989 | Adv. Exp. Med. Biol. | pmid:2696352 |
| Remuzzi G | Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. | 1989 | Adv. Exp. Med. Biol. | pmid:2696353 |
| Henson PM | PAF--a perspective. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2696514 |
| Bernardini R et al. | The alkyl-ether phospholipid platelet-activating factor is a stimulator of the hypothalamic-pituitary-adrenal axis in the rat. | 1989 | Endocrinology | pmid:2546734 |
| Pirotzky E et al. | Involvement of platelet-activating factor in renal processes. | 1989 | Adv. Lipid Res. | pmid:2698054 |
| Tanizawa H and Tai HH | Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils. | 1989 | Biochem. Pharmacol. | pmid:2547385 |
| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, and of eicosanoids- and PAF-acether antagonists on mortality and some biochemical parameters of three shock models. | 1989 | Prog. Clin. Biol. Res. | pmid:2798447 |
| O'Flaherty JT et al. | Bidirectional effects of protein kinase C activators. Studies with human neutrophils and platelet-activating factor. | 1989 | J. Biol. Chem. | pmid:2540163 |
| Bradley LM et al. | The role of lipid mediators in hypoxic pulmonary vasoconstriction in newborns. | 1989 | Prog. Clin. Biol. Res. | pmid:2798449 |
| Mest HJ et al. | The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm. | 1989 | Prog. Clin. Biol. Res. | pmid:2798457 |
| Pritze S et al. | Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro. | 1989 | Prog. Clin. Biol. Res. | pmid:2798458 |
| Dembinska-Kiec A et al. | Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. | 1989 | Prog. Clin. Biol. Res. | pmid:2798459 |
| dos Santos OF et al. | Effect of platelet-activating factor antagonist on cyclosporine nephrotoxicity. Glomerular hemodynamics evaluation. | 1989 | Transplantation | pmid:2705209 |
| Hussaini IM and Shen TY | A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543410 |
| Ukena D et al. | PAF-receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086. | 1989 | Biochem. Pharmacol. | pmid:2543419 |
| Grigorian GY et al. | Regulation of phosphoinositide turnover in endothelium from human pulmonary artery, aorta and umbilical vein. Antagonistic action on the beta-adrenoceptor coupled adenylate cyclase system. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543821 |
| Avdonin PV et al. | Selective inactivation by endogenous protein kinase C of human platelet high-affinity GTPase coupled with PAF receptors. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543823 |
| Ryan US | Endothelium as a transducing surface. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543830 |
| Straube W | [Early embryonal signals]. | 1989 | Zentralbl Gynakol | pmid:2665388 |
| Hemmendinger S et al. | Mitogenic activity on human arterial smooth muscle cells is increased in the plasma of patients undergoing hemodialysis with cuprophane membranes. | 1989 | Nephron | pmid:2812169 |
| Hermán F et al. | Decreased sensitivity of platelets to platelet-activating factor in migraine patients during the headache-free interval. | 1989 | Thromb. Haemost. | pmid:2814933 |
| Sloan IG and Firkin BG | Impaired fibrinolysis in patients with thrombotic or haemostatic defects. | 1989 | Thromb. Res. | pmid:2814943 |
| Mita H et al. | Quantitation of platelet-activating factor by high-performance liquid chromatography with fluorescent detection. | 1989 | Anal. Biochem. | pmid:2817335 |
| Barer GR et al. | Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. | 1989 | Am. Rev. Respir. Dis. | pmid:2817616 |
| Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Enhancement of chlorophyll a fluorescence yield, low-temperature F685/F730 fluorescence emission ratio, and electron transport rate by ether phospholipids (platelet activating factor and analogs) in isolated chloroplasts. | 1989 | Arch. Biochem. Biophys. | pmid:2817899 |
| Laurindo FR et al. | Mechanisms of hypotension produced by platelet-activating factor. | 1989 | J. Appl. Physiol. | pmid:2745330 |
| Adamus WS et al. | PAF-induced platelet aggregation ex vivo as a method for monitoring pharmacological activity in healthy volunteers. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2747341 |
| Etienne A et al. | Modulation of eosinophil recruitment in the rat by the platelet-activating factor (PAF) antagonist, BN 52021, the somatostatin analog, BIM 23014, and by cyclosporin A. | 1989 | Prostaglandins | pmid:2748916 |
| Petty AC and Scrutton MC | Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists? | 1989 | Thromb. Res. | pmid:2749609 |
| Gallin EK | Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. | 1989 | Am. J. Physiol. | pmid:2750892 |
| Rachmilewitz D et al. | Inflammatory mediators of experimental colitis in rats. | 1989 | Gastroenterology | pmid:2545504 |
| Dubois C et al. | Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. Prevention by PAF receptor antagonists and lipoxygenase inhibitors. | 1989 | J. Immunol. | pmid:2545780 |
| Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
| Lefer AM | Induction of tissue injury and altered cardiovascular performance by platelet-activating factor: relevance to multiple systems organ failure. | 1989 | Crit Care Clin | pmid:2650821 |
| McManus LM and Deavers SI | Platelet activating factor in pulmonary pathobiology. | 1989 | Clin. Chest Med. | pmid:2650961 |
| Braquet P et al. | Role of cytokines and platelet-activating factor in microvascular immune injury. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2651321 |
| Lee TH | Pharmacological modulation of leukotriene and platelet activating factor biosynthesis and activities by alternative dietary fatty acids. | 1989 | Clin. Exp. Allergy | pmid:2653575 |
| Straube W | [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. | 1989 | Zentralbl Gynakol | pmid:2655355 |
| Solèr M et al. | A PAF antagonist blocks antigen-induced airway hyperresponsiveness and inflammation in sheep. | 1989 | J. Appl. Physiol. | pmid:2759969 |
| Nakayama R and Saito K | Presence of 1-O-alk-1'-enyl-2-O-acetyl glycerophosphocholine (vinyl form of PAF) in perfused rat and guinea pig hearts. | 1989 | J. Biochem. | pmid:2760010 |
| Viossat I et al. | Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2622972 |
| Rylander R | Role of endotoxin and glucan for the development of granulomatous disease in the lung. | 1989 | Sarcoidosis | pmid:2623374 |
| Buckley TL and Hoult JR | Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors. | 1989 | Eur. J. Pharmacol. | pmid:2542064 |
| Teles de Araújo A et al. | Surfactant modifications and lipidic mediators in occupational lung diseases. | 1989 | Sarcoidosis | pmid:2623375 |
| Tomioka K et al. | YM461, a PAF antagonist, blocks antigen-induced late airway responses and airway hyperresponsiveness in allergic sheep. | 1989 | Eur. J. Pharmacol. | pmid:2620695 |
| Benfenati E et al. | Development of a mass spectrometric method to quantitate platelet activating factor in mouse urine. | 1989 | J. Lipid Res. | pmid:2621424 |
| Alecozay AA et al. | Platelet-activating factor in human luteal phase endometrium. | 1989 | Biol. Reprod. | pmid:2620071 |
| Tavares-de-Lima W et al. | Involvement of eicosanoids and PAF in immune-complex alveolitis. | 1989 | Braz. J. Med. Biol. Res. | pmid:2620187 |
| Prakash C et al. | Synthesis of trideuterated O-alkyl platelet activating factor and lyso derivatives. | 1989 | Lipids | pmid:2586235 |
| Tou JS | Platelet-activating factor regulates phospholipid metabolism in human neutrophils. | 1989 | Lipids | pmid:2586238 |
| Bradley LM et al. | Influence of thromboxane A2 receptor antagonism on pulmonary vasoconstrictor responses. | 1989 | Pediatr. Res. | pmid:2587116 |
| Smith D et al. | The effect of prophylactic anti-asthma drugs on PAF-induced platelet accumulation in the thorax of the guinea pig. | 1989 | Jpn. J. Pharmacol. | pmid:2593374 |
| Martiny-Baron G and Scherer GF | Phospholipid-stimulated protein kinase in plants. | 1989 | J. Biol. Chem. | pmid:2530218 |
| Tessner TG et al. | Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites. | 1989 | J. Biol. Chem. | pmid:2538461 |
| Sanjar S et al. | Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs. | 1989 | Jpn. J. Pharmacol. | pmid:2593375 |
| Jackson SP and Salem HH | Platelet aggregating activity in the plasma of patients with established thrombosis. | 1989 | Aust N Z J Med | pmid:2504137 |
| Tosaki A et al. | Possible involvement of platelet activating factor in anaphylaxis of passively sensitised, isolated guinea pig hearts. | 1989 | Cardiovasc. Res. | pmid:2557156 |
| Gabassov VA et al. | [New methodical approach to the study of platelet aggregation in vitro]. | 1989 | Biull Eksp Biol Med | pmid:2597757 |
| Kitagawa S et al. | Inhibitory effects of phenol derivatives on bovine platelet aggregation and their effects on Ca2+ mobilization. | 1989 | Biochim. Biophys. Acta | pmid:2493810 |
| Chen SH | [Purification and some properties of platelet aggregating protein (PAP) from the plasma of a patient with thrombotic thrombocytopenic purpura]. | 1989 | Zhonghua Yi Xue Za Zhi | pmid:2598093 |
| Spaethe SM et al. | Pharmacological manipulation of inflammation in rabbit hydronephrosis: effects of a combined cyclooxygenase/lipoxygenase inhibitor ethoxyquin, a thromboxane synthase inhibitor RS-5186 and a PAF antagonist L-659,989. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2539462 |
| Heymann MA | Regulation of the pulmonary circulation in the perinatal period and in children. | 1989 | Intensive Care Med | pmid:2723253 |
| Howat DW et al. | An investigation into the possible involvement of platelet activating factor in experimental allergic encephalomyelitis in rats. | 1989 | Agents Actions | pmid:2801340 |
| Chang SW et al. | Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor. | 1989 | Am. J. Physiol. | pmid:2801951 |
| Mózes T et al. | Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. | 1989 | Am. J. Physiol. | pmid:2802004 |
| Saxena SP et al. | Histamine formed in stimulated human platelets is cytoplasmic. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803292 |
| Ormerod AD et al. | Effects of alprazolam on platelet activating factor-induced wealing. | 1989 | Br. J. Dermatol. | pmid:2803963 |
| Karlström G et al. | Renal and circulatory effects of medullipin I, as studied in the in-vivo cross-circulated isolated kidney and intact Wistar-Kyoto (WKY) rat. | 1989 | Acta Physiol. Scand. | pmid:2603751 |
| Minhas BS et al. | Effects of platelet activating factor on mouse oocyte fertilization in vitro. | 1989 | Am. J. Obstet. Gynecol. | pmid:2603931 |
| Whatley RE et al. | The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. | 1989 | J. Biol. Chem. | pmid:2703492 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the initiation of the decidual reaction in the rat. | 1989 | J. Reprod. Fertil. | pmid:2703999 |
| Bylin G | [Platelet activating factor--a new agent to control asthma]. | 1989 | Lakartidningen | pmid:2921909 |
| Martins MA et al. | Pharmacological modulation of Paf-induced rat pleurisy and its role in inflammation by zymosan. | 1989 | Br. J. Pharmacol. | pmid:2924083 |
| Geissler FT et al. | Lipid mediator production by post-implantation rat embryos in vitro. | 1989 | Prostaglandins | pmid:2505333 |
| Emanuelli G et al. | Experimental acute pancreatitis induced by platelet activating factor in rabbits. | 1989 | Am. J. Pathol. | pmid:2464939 |