| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Renal Insufficiency, Chronic | D051436 | 9 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Jaundice, Obstructive | D041781 | 2 associated lipids |
| Hyperuricemia | D033461 | 4 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
| Peanut Hypersensitivity | D021183 | 2 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamazaki H | [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3027214 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Hwang SB et al. | Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. | 1986 | J. Biol. Chem. | pmid:3020044 |
| Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
| Zanetti A et al. | The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. | 1986 | Eur. J. Pharmacol. | pmid:2944757 |
| Bush LR and Smith SG | Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. | 1986 | Thromb. Res. | pmid:2948294 |
| Kloprogge E et al. | PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. | 1986 | Biochem. J. | pmid:3800968 |
| Panchenko EP et al. | [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3801147 |
| Malavasi F et al. | Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3085094 |
| Wissner A et al. | Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. | 1986 | J. Med. Chem. | pmid:3806583 |
| Simpson AW et al. | Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. | 1986 | FEBS Lett. | pmid:3086128 |
| Nakaya H and Tohse N | Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. | 1986 | Br. J. Pharmacol. | pmid:3814909 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Coëffier E et al. | Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3816952 |
| Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
| Gillespie MN and Bowdy BD | Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3944767 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Darius H et al. | Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3015804 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| O'Flaherty JT et al. | Binding and metabolism of platelet-activating factor by human neutrophils. | 1986 | J. Clin. Invest. | pmid:3016027 |
| Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| McKean ML et al. | Formation of diacyl- and alkylacylphosphatidylcholine by the membranes of human platelets. | 1986 | FEBS Lett. | pmid:3943622 |
| Ostermann G et al. | Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. | 1986 | Thromb. Res. | pmid:3764811 |
| First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
| Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
| Rosam AC et al. | Potent ulcerogenic actions of platelet-activating factor on the stomach. | 1986 Jan 2-8 | Nature | pmid:3510396 |
| Kako KJ | Membrane phospholipids and plasmalogens in the ischemic myocardium. | 1986 May-Jun | Can J Cardiol | pmid:2424580 |
| von Tscharner V et al. | Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. | 1986 Nov 27-Dec 3 | Nature | pmid:2431318 |
| Benhamou M and Mencia-Huerta JM | Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. | 1986 Sep-Oct | Ann. Inst. Pasteur Immunol. | pmid:2948525 |
| Morley J | Theophylline in asthma. | 1986 Sep-Oct | Bull Eur Physiopathol Respir | pmid:3801711 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
| Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
| Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
| Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
| Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Huber M and Keppler D | Inhibition of leukotriene D4 catabolism by D-penicillamine. | 1987 | Eur. J. Biochem. | pmid:3622511 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
| Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Siess W and Lapetina EG | Phorbol esters sensitize platelets to activation by physiological agonists. | 1987 | Blood | pmid:3663938 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Bienenstock J et al. | Mast cell involvement in various inflammatory processes. | 1987 | Am. Rev. Respir. Dis. | pmid:3109295 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
| Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
| Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
| Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
| Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| Tou JS | Platelet-activating factor modulates phospholipid acylation in human neutrophils. | 1987 | Lipids | pmid:3110533 |
| Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
| Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bussolino F et al. | Intravascular release of platelet activating factor in children with sepsis. | 1987 | Thromb. Res. | pmid:3441909 |
| Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |