| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee TC et al. | Biosynthesis of N-acetylsphingosine by platelet-activating factor: sphingosine CoA-independent transacetylase in HL-60 cels. | 1996 | J. Biol. Chem. | pmid:8550561 |
| Sibelius U et al. | Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells. | 1996 | Infect. Immun. | pmid:8550226 |
| Meijer F et al. | Nitric oxide induces vascular permeability changes in the guinea pig conjunctiva. | 1995 | Eur. J. Pharmacol. | pmid:8549637 |
| Evangelou A et al. | Inhibition of PAF-acether effects on isolated guinea pig hearts by zinc ions (Zn2+). | 1995 | Biol Trace Elem Res | pmid:8546883 |
| Rubio de Krömer MT et al. | Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. | 1995 | Acta Trop. | pmid:8546035 |
| Furukawa M et al. | Biochemical evidence of platelet-activating factor (PAF) in human middle ear effusions. | 1995 | Laryngoscope | pmid:8544602 |
| Naraba H et al. | Activation of phospholipase A2 and acylation of lysophospholipids: the major regulators for platelet activating factor production in rat neutrophils. | 1995 | J. Biochem. | pmid:8543583 |
| Abu-Zidan FM et al. | Role of platelet-activating factor antagonism in haemorrhagic shock in pigs. | 1995 | Eur Surg Res | pmid:8542923 |
| Izumi T and Shimizu T | Platelet-activating factor receptor: gene expression and signal transduction. | 1995 | Biochim. Biophys. Acta | pmid:8541341 |
| Siminiak T et al. | Plasma mediated neutrophil stimulation during coronary angioplasty: autocrine effect of platelet activating factor. | 1995 | Br Heart J | pmid:8541167 |
| Cluzel J et al. | Inhibition of platelet-activating factor-induced retinal impairments by cholera and pertussis toxins. | 1995 | Ophthalmic Res. | pmid:8538992 |
| RamÃrez MM et al. | Platelet activating factor modulates microvascular permeability through nitric oxide synthesis. | 1995 | Microvasc. Res. | pmid:8538502 |
| Schwappach JR et al. | Superoxide dismutase attenuates effects of platelet-activating factor on gastric microcirculation. | 1995 | J. Surg. Res. | pmid:8538173 |
| Guimbaud R et al. | Intraluminal excretion of PAF, lysoPAF, and acetylhydrolase in patients with ulcerative colitis. | 1995 | Dig. Dis. Sci. | pmid:8536524 |
| Bustos C et al. | Cyclosporin A (CsA) modulates the glomerular production of inflammatory mediators and proteoglycans in experimental nephrosis. | 1995 | Clin. Exp. Immunol. | pmid:8536380 |
| Schmid E et al. | Signaling by E-selectin and ICAM-1 induces endothelial tissue factor production via autocrine secretion of platelet-activating factor and tumor necrosis factor alpha. | 1995 | J. Interferon Cytokine Res. | pmid:8536111 |
| Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
| Kirejczyk JK et al. | Oxygen-derived free radicals in kidney in experimental hemorrhagic shock treated by PAF-receptor antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528997 |
| Kirejczyk JK et al. | Ginkgolide BN 52021 protects against hemorrhagic shock-induced renal injury in rats. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528996 |
| Debek W et al. | Luminol-chemiluminescence in free peritoneal cells in hemorrhagic shock in rats treated with PAF-receptor-antagonist BN 52021. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8528982 |
| Ahmed A et al. | Oestradiol-17 beta modulates PAF-evoked phospholipase D activity but not inositide-lipid hydrolysis in human endometrial cell line, HEC-1B. | 1995 | Cell. Signal. | pmid:8527309 |
| Oshiro H et al. | L-type calcium channel blockers modulate the microvascular hyperpermeability induced by platelet-activating factor in vivo. | 1995 | J. Vasc. Surg. | pmid:8523608 |
| Noel AA et al. | Inhibition of nitric oxide synthase attenuates primed microvascular permeability in the in vivo microcirculation. | 1995 | J. Vasc. Surg. | pmid:8523600 |
| Nishida K et al. | Increased brain levels of platelet-activating factor in a murine acquired immune deficiency syndrome are NMDA receptor-mediated. | 1996 | J. Neurochem. | pmid:8522986 |
| Diserbo M et al. | Stimulation of platelet-activating factor (PAF) receptors increases inositol phosphate production and cytosolic free Ca2+ concentrations in N1E-115 neuroblastoma cells. | 1995 | Cell Calcium | pmid:8521458 |
| Nishi O et al. | Effects of platelet activating factor on mouse embryo implantation in vitro. | 1995 | J. Assist. Reprod. Genet. | pmid:8520198 |
| Okano S et al. | Effect of platelet activating factor antagonist (TCV-309) on lung injury in dogs with experimentally endotoxin-induced shock. | 1995 | J. Vet. Med. Sci. | pmid:8519912 |
| Amorim CZ et al. | Involvement of platelet-activating factor in death following anaphylactic shock in boosted and in unboosted mice. | 1993 | Eur. J. Pharmacol. | pmid:8519279 |
| Kawahara K et al. | The effect of the platelet-activating factor inhibitor TCV-309 on reperfusion injury in a canine model of ischemic lung. | 1993 | Transplantation | pmid:8516834 |
| Nishiyama R et al. | Platelet-activating factor in hepatic ischemia/reperfusion injury. The effects of a PAF antagonist combined with a prostaglandin I2 analogue. | 1993 | Transplantation | pmid:8516812 |
| Rabinovici R et al. | ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats. | 1993 | J. Appl. Physiol. | pmid:8514698 |
| Koyama N et al. | Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus. | 1993 | Clin. Chim. Acta | pmid:8513570 |
| Dell' Albani P et al. | Platelet-activating factor and its methoxy-analogue ET-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures. | 1993 | Neurochem. Int. | pmid:8513284 |
| Warringa RA et al. | Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8509580 |
| van den Bosch H et al. | Ether lipid synthesis and its deficiency in peroxisomal disorders. | 1993 | Biochimie | pmid:8507680 |
| Ono I et al. | Effects of a platelet activating factor antagonist on oedema formation following burns. | 1993 | Burns | pmid:8507364 |
| Tsukioka K et al. | [Increased plasma levels of platelet-activating factor (PAF) and low serum PAF acetylhydrolase (PAFAH) activity in adult patients with bronchial asthma]. | 1993 | Arerugi | pmid:8507159 |
| Misawa M and Sugiyama Y | An airway hyperresponsiveness model in rat allergic asthma. | 1993 | Arerugi | pmid:8507151 |
| Sirén AL et al. | Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. | 1993 | Stroke | pmid:8506560 |
| Davis TM et al. | Platelet-activating factor and lipid metabolism in acute malaria. | 1993 | J. Infect. | pmid:8505562 |
| Ferraris L et al. | Intestinal epithelial cells contribute to the enhanced generation of platelet activating factor in ulcerative colitis. | 1993 | Gut | pmid:8504968 |
| Baldi E et al. | Stimulation of platelet-activating factor synthesis by progesterone and A23187 in human spermatozoa. | 1993 | Biochem. J. | pmid:8503848 |
| Sun DX et al. | Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503282 |
| Pfliegler G et al. | Sodium fluoride induced activation of phospholipase C in intact human platelets does not depend on ADP, PAF or arachidonate products. | 1993 | Thromb. Res. | pmid:8503122 |
| Inoue H et al. | Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF. | 1993 | Life Sci. | pmid:8502110 |
| Chu M et al. | A novel class of platelet activating factor antagonists from Phoma sp. | 1993 | J. Antibiot. | pmid:8500998 |
| Roudebush WE et al. | Enhanced embryo development of rabbit oocytes fertilized in vitro with platelet activating factor (PAF)-treated spermatozoa. | 1993 | J. Assist. Reprod. Genet. | pmid:8499686 |
| Wilson DV and Stick JA | Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. | 1993 | Am. J. Vet. Res. | pmid:8498751 |
| Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
| Miura S et al. | Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid. | 1993 | Am. J. Physiol. | pmid:8498509 |
| Trova MP et al. | Analogues of platelet activating factor. 8. Antagonists of PAF containing an aromatic ring linked to a pyridinium ring. | 1993 | J. Med. Chem. | pmid:8496938 |
| Jarvi K et al. | Effect of platelet-activating factor, lyso-platelet-activating factor, and lysophosphatidylcholine on sperm motion: importance of albumin for motility stimulation. | 1993 | Fertil. Steril. | pmid:8495776 |
| Pons F et al. | Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505. | 1993 | Br. J. Pharmacol. | pmid:8495241 |
| Nathan N and Denizot Y | Tumor necrosis factor and platelet-activating factor during cardiopulmonary bypass. | 1993 | Ann. Thorac. Surg. | pmid:8494455 |
| Zhou W et al. | Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. | 1993 | Am. J. Pathol. | pmid:8494049 |
| Alabaster VA and Moore BA | New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future. | 1993 | Thorax | pmid:8493636 |
| Wagner G et al. | [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-formamidines corresponding alkyl esters with antianaphylactic activity]. | 1993 | Pharmazie | pmid:8493283 |
| Fukuda T | [The eosinophil and bronchial asthma]. | 1993 | Nippon Rinsho | pmid:8492453 |
| Iwahisa Y et al. | [Advance in eosinophil chemotaxis assay method--automatic count of migrated cells by the image analyzing system in the Boyden method]. | 1993 | Nippon Rinsho | pmid:8492448 |
| Kawada I and Takahashi K | [A new method for the isolation of peripheral blood eosinophils using flow cytometry (FCM)]. | 1993 | Nippon Rinsho | pmid:8492447 |
| Cipolle MD et al. | Secondary organ dysfunction. From clinical perspectives to molecular mediators. | 1993 | Crit Care Clin | pmid:8490763 |
| Sablina MA et al. | [Synthesis of platelet activation factor analogs]. | 1993 | Bioorg. Khim. | pmid:8489534 |
| Lekka M et al. | Isolation of a phospholipid inhibitor of platelet activating factor-induced activity from perfused rat liver: identification as phosphatidylglycerol. | 1993 | Arch. Biochem. Biophys. | pmid:8489242 |
| Steinke B et al. | [Biological standardization of Ginkgo extracts]. | 1993 | Planta Med. | pmid:8488195 |
| Barthelson RA | Quantitation of IL-4 expression in small numbers of cells from mice. | 1993 | J. Immunol. Methods | pmid:8486929 |
| Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
| Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
| Yamanaka S et al. | 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. | 1993 | Prostaglandins | pmid:8484010 |
| van der Bruggen T et al. | Cytokine priming of the respiratory burst in human eosinophils is Ca2+ independent and accompanied by induction of tyrosine kinase activity. | 1993 | J. Leukoc. Biol. | pmid:8482914 |
| Sakamoto T et al. | Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig. | 1993 | J. Appl. Physiol. | pmid:8482649 |
| Kiyohara T et al. | Effect of endothelin 1 on ion transport in isolated rat colon. | 1993 | Gastroenterology | pmid:8482447 |
| Kroegel C et al. | Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma. | 1993 | Clin. Sci. | pmid:8482044 |
| Koenderman L et al. | Granulocyte-macrophage colony-stimulating factor induces sequential activation and deactivation of binding via a low-affinity IgG Fc receptor, hFc gamma RII, on human eosinophils. | 1993 | Blood | pmid:8481520 |
| Hebra A et al. | Systemic and mesenteric vascular effects of platelet-activating factor and cocaine. In vivo effects on a neonatal swine model. | 1993 | Am Surg | pmid:8480932 |
| Murphy G | Report of the 14th meeting of the British Inflammation Research Association. Topic: cellular and molecular aspects of inflammatory bowel disease. | 1993 | Agents Actions | pmid:8480529 |
| Ranaut K and Singh M | BN-50739: a PAF antagonist and limitation of myocardial infarct size. | 1993 Jan-Feb | Methods Find Exp Clin Pharmacol | pmid:8479250 |
| Lamouri A et al. | Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines. | 1993 | J. Med. Chem. | pmid:8478911 |
| Walker TS and Mellott GE | Rickettsial stimulation of endothelial platelet-activating factor synthesis. | 1993 | Infect. Immun. | pmid:8478089 |
| Makristathis A et al. | Bacteria induce release of platelet-activating factor (PAF) from polymorphonuclear neutrophil granulocytes: possible role for PAF in pathogenesis of experimentally induced bacterial pneumonia. | 1993 | Infect. Immun. | pmid:8478087 |
| Björck T and Dahlén SE | Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. | 1993 | Pulm Pharmacol | pmid:8477156 |
| Minhas BS | Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475981 |
| Inui K | [Participation of platelet activating factor in the pulmonary injury during cardiopulmonary bypass]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8473789 |
| Juncos LA et al. | Vasodilator and constrictor actions of platelet-activating factor in the isolated microperfused afferent arteriole of the rabbit kidney. Role of endothelium-derived relaxing factor/nitric oxide and cyclooxygenase products. | 1993 | J. Clin. Invest. | pmid:8473488 |
| Kroegel C and Matthys H | Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics. | 1993 | Immunology | pmid:8473016 |
| Taylor ML et al. | The differential effect of aspirin on human platelet activation in aspirin-sensitive asthmatics and normal subjects. | 1993 | Br J Clin Pharmacol | pmid:8471399 |
| Sandberg-Gertzén H | An open trial of Cedemin, a Gingko biloba extract with PAF-antagonistic effects for ulcerative colitis. | 1993 | Am. J. Gastroenterol. | pmid:8470656 |
| Fukuoka T et al. | Platelet activating factor mediates systemic circulatory collapse after temporary hepatic inflow occlusion. | 1993 | Transplant. Proc. | pmid:8470175 |
| Tetta C et al. | Role of platelet activating factor in hemodialysis. | 1993 | Kidney Int. Suppl. | pmid:8468919 |
| Shikano M et al. | Effect of docosahexaenoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-1. | 1993 | J. Immunol. | pmid:8468486 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on guineapig airway microvascular leakage induced by platelet-activating factor and other allergic mediators. | 1993 | Int. J. Immunopharmacol. | pmid:8468119 |
| McCafferty DM et al. | Inhibition of platelet-activating factor-induced leukocyte adhesion in vivo by a leumedin. | 1993 | Eur. J. Pharmacol. | pmid:8467855 |
| Ono S et al. | Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. | 1993 | Surg. Today | pmid:8467174 |
| Korth R et al. | Human platelets release a paf-acether: acetylhydrolase similar to that in plasma. | 1993 | Lipids | pmid:8464350 |
| Nagai H et al. | Priming with murine recombinant interleukin-5 resulted in the augmentation of PAF-induced airway hyperresponsiveness to histamine in guinea pigs. | 1993 | Life Sci. | pmid:8464339 |
| Battye KM et al. | Potential synergism between platelet-activating factor and alpha 1-recombinant interferon in promoting luteal maintenance in cyclic ewes. | 1993 | J. Reprod. Fertil. | pmid:8464013 |
| Venable ME et al. | Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. | 1993 | J. Biol. Chem. | pmid:8463317 |
| Wieraszko A et al. | Long-term potentiation in the hippocampus induced by platelet-activating factor. | 1993 | Neuron | pmid:8461142 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Kertscher HP et al. | [PAF-antagonists with a phospholipid structure. 5. Propanediol phospholipids with various substituted pyridinium and quinuclidinium head groups and variations of the phosphorus-nitrogen distance;synthesis, characterization and structure activity relationship]. | 1993 | Pharmazie | pmid:8460172 |
| Kosugi T et al. | Inhalation of platelet-activating factor increases respiratory resistance in rats: determination by means of an astograph under nonanesthetized conditions. | 1993 | Laryngoscope | pmid:8459752 |