| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Barnes PJ | Platelet activating factor and asthma. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659278 |
| Hwang SB | Function and regulation of extracellular and intracellular receptors of platelet activating factor. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659279 |
| O'Donnell M | Effects of Ro 24-4736 in antagonizing the platelet and bronchoconstrictor responses to PAF. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1659287 |
| Dray F et al. | Prostaglandin E2, leukotriene C4, and platelet-activating factor receptor sites in the brain. Binding parameters and pharmacological studies. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2549827 |
| Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
| Thivierge M and Rola-Pleszczynski M | Involvement of both cyclooxygenase and lipoxygenase pathways in platelet-activating factor-induced interleukin-6 production by alveolar macrophages. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030993 |
| Tamura K et al. | The effects of platelet activating factor antagonist, TCV309, on the relationship between electrophysiological and mechanical status during myocardial ischemia and reperfusion. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030887 |
| Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
| Rabinovici R et al. | Cytokine gene and peptide regulation in lung microvascular injury: new insights on the development of adult respiratory distress syndrome. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031006 |
| Neville LF et al. | Application of differential display to isolate novel genes in interleukin-2-induced adult respiratory distress syndrome. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8906233 |
| Asmis R and Dennis EA | Regulation of prostaglandin E2 production in P388D1 macrophage-like cells. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825831 |
| Welton AF et al. | Studies of the combination of Ro 24-5913, a peptidoleukotriene antagonist, and Ro 24-4736, a PAF antagonist, in guinea pig and rat models of lung inflammation. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7825850 |
| Snyder F et al. | Platelet-activating factor and related ether lipid mediators. Biological activities, metabolism, and regulation. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2698076 |
| Bito H et al. | Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:9137600 |
| Panetta T et al. | Arachidonic acid metabolism and cerebral blood flow in the normal, ischemic, and reperfused gerbil brain. Inhibition of ischemia-reperfusion-induced cerebral injury by a platelet-activating factor antagonist (BN 52021). | 1989 | Ann. N. Y. Acad. Sci. | pmid:2774404 |
| Powell DW | Epithelial secretory responses to inflammation. Platelet activating factor and reactive oxygen metabolites. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456654 |
| Willard AL | Excitatory and neurotoxic actions of platelet-activating factor on rat myenteric neurons in cell culture. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1456659 |
| Mullane KM et al. | Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837948 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Braquet P et al. | The role of platelet-activating factor in cerebral ischemia and related disorders. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2672941 |
| Klöcking HP | Inhibition of PAF-induced tPA release by KO-286011. | 1992 | Ann. N. Y. Acad. Sci. | pmid:1309038 |
| Onorato JM et al. | Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928437 |
| O'Neill C et al. | Embryo-derived platelet-activating factor. Its diagnostic and therapeutic future. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3195924 |
| Snyder F et al. | Metabolism of platelet activating factor in lung. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952548 |
| Krell RD and McCarthy M | Pharmacologic analysis of platelet activating factor16- and 18-induced bronchoconstriction in the guinea pig. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952549 |
| Gundel RH et al. | The role of platelet activating factor in airway inflammation, airway hyperresponsiveness, and pulmonary function in monkeys. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952550 |
| Burrows LJ et al. | Intraperitoneal injection of human recombinant neutrophil-activating factor/interleukin 8 (hrNAF/IL-8) produces a T cell and eosinophil infiltrate in the guinea pig lung. Effect of PAF antagonist WEB2086. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952566 |
| Spencer DA et al. | The effects of a 5-lipoxygenase inhibitor, BW A4C, on the acute response to inhaled PAF in man. | 1991 | Ann. N. Y. Acad. Sci. | pmid:1952568 |
| Boulay F et al. | Phagocyte chemoattractant receptors. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9704038 |
| Schröder JM et al. | RANTES, a novel eosinophil-chemotactic cytokine. | 1994 | Ann. N. Y. Acad. Sci. | pmid:7518215 |
| Nakamura T et al. | Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8363265 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Tuomanen EI | Molecular and cellular mechanisms of pneumococcal meningitis. | 1996 | Ann. N. Y. Acad. Sci. | pmid:8993350 |
| Marcus AJ et al. | Arachidonic acid metabolism in endothelial cells and platelets. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6762834 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Vargaftig BB et al. | Background and present status of research on platelet-activating factor (PAF-acether). | 1981 | Ann. N. Y. Acad. Sci. | pmid:7023317 |
| Coëffier E et al. | Modulation of the enhanced migration of eosinophils from the airways of sensitized guinea pigs: role of IL-5. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8030999 |
| Karpatkin S et al. | Role of platelets in tumor cell metastases. | 1981 | Ann. N. Y. Acad. Sci. | pmid:6943955 |
| Piper PJ et al. | Release of leukotrienes from porcine and human blood vessels by immunological and nonimmunological stimuli. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837950 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Lindsberg PJ et al. | Platelet-activating factor in stroke and brain injury. | 1991 | Ann. Neurol. | pmid:1897906 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
| Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
| Rhee CK et al. | Experimental otitis media with effusion induced by platelet activating factor. | 1993 | Ann. Otol. Rhinol. Laryngol. | pmid:8352483 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |