| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sahu RP et al. | The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. | 2012 | Carcinogenesis | pmid:22542595 |
| Sato A et al. | Synthetic biotinylated peptide compounds derived from Asp-hemolysin: novel potent inhibitors of platelet-activating factor. | 2012 | Eur. J. Pharmacol. | pmid:22542654 |
| Bachi AL et al. | Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor. | 2012 | Mediators Inflamm. | pmid:22577252 |
| Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
| Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
| Kim HA et al. | Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis. | 2012 | Eur. J. Cancer | pmid:21889331 |
| Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
| Xiong J et al. | New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation. | 2012 | Eur J Pharm Sci | pmid:22285483 |
| Flaherty MM et al. | Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice. | 2012 | Toxicol. Sci. | pmid:22025730 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
| Widgerow AD and Kalaria S | Pain mediators and wound healing--establishing the connection. | 2012 | Burns | pmid:22738827 |
| Altomare A et al. | Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls. | 2012 | Neurogastroenterol. Motil. | pmid:22734465 |
| Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
| Kolovou V et al. | Platelet activating factor levels and metabolism in Tangier disease: a case study. | 2012 | Lipids Health Dis | pmid:22769014 |
| Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
| Liu M et al. | Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion. | 2012 | PLoS Pathog. | pmid:22496650 |
| Vadas P and Perelman B | Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells. | 2012 | J. Allergy Clin. Immunol. | pmid:22460068 |
| Masliakov VV et al. | [Microcirculation in the injured spleen by different operations in children]. | 2012 | Khirurgiia (Mosk) | pmid:23257700 |
| Zia-Ul-Haq M et al. | Report: Platelet aggregation inhibition activity of selected legumes of Pakistan. | 2012 | Pak J Pharm Sci | pmid:23010006 |
| Petho G and Reeh PW | Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors. | 2012 | Physiol. Rev. | pmid:23073630 |