Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Krämer K et al. Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. 1993 Z Ernahrungswiss pmid:8237077
Becker BF et al. [Interaction of adenosine with leukocytes and thrombocytes]. 1996 Z Kardiol pmid:9064961
Marzi I et al. [Involvement of platelet activating factors in pathologic leukocyte-endothelium interactions in the liver after hemorrhagic shock]. 1994 Zentralbl Chir pmid:7846961
Uhlmann D et al. Importance of microcirculatory disturbances in the pathogenesis of pancreatitis. 2001 Zentralbl Chir pmid:11753796
Straube W [Early embryonal signals]. 1989 Zentralbl Gynakol pmid:2665388
Straube W [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. 1989 Zentralbl Gynakol pmid:2655355
Van de Weerdt ML et al. Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. 1999 Zentralbl Veterinarmed A pmid:10216447
Bastos da Silva M et al. Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. 1997 Zentralbl Veterinarmed A pmid:9284631
da Silva MB et al. Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. 1996 Zentralbl Veterinarmed A pmid:8921726
Poveshchenko AF and Kozlov VA [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. 1999 Jul-Aug Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:10852052
Shebzukhov IuV et al. [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. 1996 May-Jun Zh. Mikrobiol. Epidemiol. Immunobiol. pmid:8771751
Zhao XY et al. [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. 2003 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:12970925
Xie DS and Xie YT [Role of platelet activating factor in hepatorenal syndrome]. 2005 Zhong Nan Da Xue Xue Bao Yi Xue Ban pmid:16045031
Zong RK and Liu J [Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis]. 2011 Zhong Xi Yi Jie He Xue Bao pmid:22152774
Xiao HS [Relation of blood platelets and the cause of bronchial asthma]. 1989 Zhong Xi Yi Jie He Za Zhi pmid:2532572
Li X and Luo H [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. 2002 Zhong Yao Cai pmid:14748373
Xu CL et al. [Inhibitory effect of TBN on platelet aggregation in rabbit]. 2010 Zhong Yao Cai pmid:21243778
Zhang XT et al. [Study on the pharmacokinetics of ginkgolide B for injection in rats]. 2012 Zhong Yao Cai pmid:22876684
Zhang XT et al. [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. 2012 Zhong Yao Cai pmid:23213741
Huang GD et al. [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. 2007 Zhong Yao Cai pmid:18422199