| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee T et al. | Increased biosynthesis of platelet-activating factor in activated human eosinophils. | 1984 | J. Biol. Chem. | pmid:6425292 |
| Hallam TJ et al. | Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. | 1984 | Biochem. J. | pmid:6426464 |
| Mueller HW et al. | 1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. | 1984 | J. Lipid Res. | pmid:6427378 |
| Valone FH | Isolation of a platelet membrane protein which binds the platelet-activating factor 1-0-hexadecyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1984 | Immunology | pmid:6325330 |
| Kramp W et al. | Observations on the critical micellar concentration of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine and a series of its homologs and analogs. | 1984 | Chem. Phys. Lipids | pmid:6744496 |
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Lefort J et al. | The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene. | 1984 | Br. J. Pharmacol. | pmid:6430375 |
| Hamasaki Y et al. | Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. | 1984 | Am. Rev. Respir. Dis. | pmid:6547031 |
| Morley J et al. | The platelet in asthma. | 1984 | Lancet | pmid:6150192 |
| Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
| Hanahan DJ and Nelson DR | Phospholipids as dynamic participants in biological processes. | 1984 | J. Lipid Res. | pmid:6152281 |
| Lewis AJ et al. | The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. | 1984 | Agents Actions | pmid:6152379 |
| Cervoni P et al. | Evidence for the lack of interaction between (+/-)-1-O-octadecyl-2-acetylglyceryl-3-phosphorylcholine and alpha-adrenoceptors in vivo and in vitro. | 1984 | Br. J. Pharmacol. | pmid:6091835 |
| Fink KL and Gross RW | Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds. | 1984 | Circ. Res. | pmid:6091941 |
| Kulikov VI and Bergel'son LD | [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. | 1984 | Biokhimiia | pmid:6093897 |
| Haye B et al. | Interactions between thyreostimulin and PAF-acether on thyroid cell metabolism. | 1984 | Eur. J. Pharmacol. | pmid:6094205 |
| Gordeev KIu et al. | [A bioregulator of lipid nature--a platelet activating factor (PAF)]. | 1984 | Bioorg. Khim. | pmid:6099122 |
| Wang ZY | [Advances in the physiopathology of platelets]. | 1984 | Zhonghua Nei Ke Za Zhi | pmid:6099795 |
| Wasserman SI | The human lung mast cell. | 1984 | Environ. Health Perspect. | pmid:6428878 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Nishihira J et al. | Production and characterization of specific antibodies against 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a potent hypotensive and platelet-activating ether-linked phospholipid). | 1984 | J. Biochem. | pmid:6430883 |
| Feuerstein G et al. | Hypotension produced by platelet-activating factor is reversed by thyrotropin-releasing hormone. | 1984 | Circ. Shock | pmid:6432359 |
| Parnham MJ et al. | Regulation of the oxidative burst of macrophages by lipid mediators. | 1984 | Agents Actions Suppl. | pmid:6433680 |
| O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Fouque F and Vargaftig BB | Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. | 1984 | Br. J. Pharmacol. | pmid:6439269 |
| Karlsson G and Pipkorn U | Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6439565 |
| Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
| Handley DA et al. | Effect of platelet activating factor on endothelial permeability to plasma macromolecules. | 1984 | Immunopharmacology | pmid:6083990 |
| Camussi G et al. | Effect of platelet activating factor on guinea-pig papillary muscle. | 1984 | Experientia | pmid:6086382 |
| Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Bussolino F et al. | Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. | 1984 | Cell Calcium | pmid:6549153 |
| Pirotzky E et al. | Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. | 1984 | Lab. Invest. | pmid:6492758 |
| Handley DA et al. | Evaluation of dose and route effects of platelet activating factor-induced extravasation in the guinea pig. | 1984 | Thromb. Haemost. | pmid:6495262 |
| Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| Lichey J et al. | Pressure effects and uptake of platelet-activating factor in isolated rat lung. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6501025 |
| Buxton DB et al. | Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobulin G in the perfused rat liver. | 1984 | J. Biol. Chem. | pmid:6501277 |
| White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
| Mueller HW et al. | The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils. | 1984 | J. Biol. Chem. | pmid:6501307 |
| Goldenberg MM and Meurer RD | A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat. | 1984 | Prostaglandins | pmid:6505225 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 1. Some modifications of the alkoxy chain. | 1984 | J. Med. Chem. | pmid:6471071 |
| Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
| Nishizawa EE and Della-Coletta AA | The formation of a thrombin-like material (TLM) following stimulation of leukocytes. | 1984 | Thromb. Res. | pmid:6484896 |
| Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
| Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
| Nakamura N et al. | Synthesis and biological activities of bioisosteric O-carba-analogues of platelet activating factor (PAF). | 1984 | Chem. Pharm. Bull. | pmid:6488414 |
| Sakamoto H et al. | Stimulation of leukocyte phagocytic activity by the platelet release reaction. | 1984 | Pathology | pmid:6462776 |
| Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
| Chilton FH et al. | 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes. | 1984 | J. Biol. Chem. | pmid:6434535 |
| Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
| Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
| Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
| Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
| Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
| Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Söling HD et al. | Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. | 1984 | Eur. J. Biochem. | pmid:6207023 |
| Hoffman DR et al. | Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. | 1984 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6739956 |
| Mohanty D and Hilgard P | A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. | 1984 | Thromb. Haemost. | pmid:6740552 |
| Lalau Keraly C et al. | Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. | 1984 | Thromb. Res. | pmid:6740569 |
| Ostermann G et al. | Halo lipids. VI. Stimulation of human and rabbit blood platelets by racemic halo analogues of O-alkyl-glycerophosphocholine. | 1984 | Biomed. Biochim. Acta | pmid:6743307 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Albert DH and Snyder F | Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6435681 |
| Hoffman DR et al. | Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. | 1984 | Blood | pmid:6696992 |
| Basran GS et al. | Platelet-activating factor: a possible mediator of the dual response to allergen? | 1984 | Clin. Allergy | pmid:6697475 |
| Kelton JG et al. | Clinical usefulness of testing for a heparin-dependent platelet-aggregating factor in patients with suspected heparin-associated thrombocytopenia. | 1984 | J. Lab. Clin. Med. | pmid:6699475 |
| Feuerstein G et al. | Effect of platelet-activating factor on coronary circulation of the domestic pig. | 1984 | Am. J. Physiol. | pmid:6703081 |
| Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
| Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
| Clare KA and Scrutton MC | The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). | 1984 | Eur. J. Biochem. | pmid:6705791 |
| Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| El Tamer A et al. | Studies on ether phospholipids. I. A new method of determination using phospholipase A1 from guinea pig pancreas: application to Krebs II ascites cells. | 1984 | Biochim. Biophys. Acta | pmid:6712966 |
| Touqui L et al. | Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets. | 1984 | Experientia | pmid:6714369 |
| Masugi F et al. | [Etiological studies of hypertension. G. APRL (antihypertensive polar renomedullary lipid)]. | 1984 | Nippon Rinsho | pmid:6716685 |
| Kester M et al. | The potentiation of arterial contraction with platelet activating factor. | 1984 | Pflugers Arch. | pmid:6718228 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates phospholipase in quiescent Swiss mouse 3T3 fibroblast. | 1984 | FEBS Lett. | pmid:6436057 |
| Kramer RM et al. | Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | 1984 | J. Biol. Chem. | pmid:6436245 |
| Andreesen R et al. | Tumor cytotoxicity of human macrophages after incubation with synthetic analogues of 2-lysophosphatidylcholine. | 1984 | J. Natl. Cancer Inst. | pmid:6582303 |
| Prescott SM et al. | Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6587368 |
| Iñarrea P et al. | Characteristics of the binding of platelet-activating factor to platelets of different animal species. | 1984 | Eur. J. Pharmacol. | pmid:6510472 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
| Schleimer RP et al. | Inflammatory mediators and mechanisms of release from purified human basophils and mast cells. | 1984 | J. Allergy Clin. Immunol. | pmid:6208229 |
| O'Neill C and Saunders DM | Assessment of embryo quality. | 1984 | Lancet | pmid:6149413 |
| Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
| Infante JP | Biosynthesis of acyl-specific glycerophospholipids in mammalian tissues. Postulation of new pathways. | 1984 | FEBS Lett. | pmid:6373368 |
| Camussi G et al. | Platelet-activating factor-induced loss of glomerular anionic charges. | 1984 | Kidney Int. | pmid:6374251 |
| Schlondorff D et al. | Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. | 1984 | J. Clin. Invest. | pmid:6423667 |
| Vargaftig BB et al. | [Platelet aggregation and PAF-acether. Pharmacologic interference]. | 1984 | J Pharmacol | pmid:6374298 |
| Ito S et al. | Hyperacute renal allograft rejection in the rabbit. The role of platelet-activating factor and of cationic proteins derived from polymorphonuclear leukocytes and from platelets. | 1984 | Lab. Invest. | pmid:6379289 |
| Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
| Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
| Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
| Bussolino F et al. | Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines. | 1984 | Exp. Hematol. | pmid:6333353 |