Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
| Wang MM et al. | In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. | 1999 | Biochim. Biophys. Acta | pmid:9989266 |
| Snyder F | The ether lipid trail: a historical perspective. | 1999 | Biochim. Biophys. Acta | pmid:9989259 |
| Syrbu SI et al. | Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. | 1999 | J. Immunol. | pmid:9973512 |
| Hayani KC et al. | Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children. | 1999 | J. Infect. Dis. | pmid:9952364 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Piwinski JJ et al. | Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934454 |
| Lee LW et al. | Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. | 1999 | Eur. J. Pharmacol. | pmid:9932729 |
| Ohshige A et al. | Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. | 1999 | Obstet Gynecol | pmid:9932551 |
| Bazan NG | The neuromessenger platelet-activating factor in plasticity and neurodegeneration. | 1998 | Prog. Brain Res. | pmid:9932449 |
| McCall MR et al. | Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility. | 1999 | Biochim. Biophys. Acta | pmid:9931415 |
| Onorato JM et al. | Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928437 |
| Berger A et al. | Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927381 |
| Toledano BJ et al. | Characterization of B lymphocytes rescued from apoptosis by platelet-activating factor. | 1999 | Cell. Immunol. | pmid:9918687 |
| Gedeborg R and Wiklund L | Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. | 1998 Oct-Nov | Resuscitation | pmid:9918458 |
| Stafforini DM and Tjoelker LW | Human plasma platelet-activating factor acetylhydrolase. | 1999 | Methods Mol. Biol. | pmid:9918011 |
| Siddiqui RA et al. | Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes. | 1999 | J. Immunol. | pmid:9916736 |
| Zhang Y et al. | RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. | 1999 | J. Biol. Chem. | pmid:9915820 |
| Qu XW et al. | The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. | 1999 | Gut | pmid:9895379 |
| Tetta C et al. | The role of platelet-activating factor in the haemoincompatibility of haemodialytic treatments. | 1998 | Int J Artif Organs | pmid:9894743 |
| Yamaguchi S et al. | Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice. | 1998 | Inflamm. Res. | pmid:9892046 |
| Akiba S et al. | Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9891858 |
| Longphre M et al. | Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF. | 1999 | J. Appl. Physiol. | pmid:9887149 |
| Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Chang FR et al. | Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea. | 1998 | Phytochemistry | pmid:9883592 |
| Nakano T et al. | Roxythromycin reinforces epithelial defence function in rabbit trachea. | 1998 | Acta Otolaryngol Suppl | pmid:9879427 |
| Todoroki H et al. | Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. | 1998 | J. Surg. Res. | pmid:9878306 |
| Kawasaki Y et al. | Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens. | 1998 | FEBS Lett. | pmid:9877177 |
| Dhainaut JF et al. | Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group. | 1998 | Crit. Care Med. | pmid:9875905 |
| Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
| Huh H et al. | PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra. | 1998 | Arch. Pharm. Res. | pmid:9875472 |
| Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
| Chen JZ et al. | A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871752 |
| Powell WS et al. | 5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:9870930 |
| pmid:9870780 | ||||
| Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
| Kaminskaia GO et al. | [Oxidative metabolic changes, antioxidantion, and platelet activation rat phagocytes during development of experimental specific tuberculous changes]. | 1998 | Probl Tuberk | pmid:9866402 |
| Pesce L et al. | Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs. | 1998 | Respir Physiol | pmid:9865589 |
| Hammer C et al. | Xenogeneic rejection mechanisms shown by intravital microscopy. | 1998 | Transplant. Proc. | pmid:9865335 |
| Jeanneton O et al. | Correlation of desensitisation of platelet activating factor (PAF) receptors with intensity of inflammation and intestinal PAF content during experimental ileitis in guinea pig. | 1998 | Gut | pmid:9863481 |
| Nagai H et al. | Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice. | 1999 | J. Pharmacol. Exp. Ther. | pmid:9862751 |
| Egesten A and Malm J | Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C. | 1998 | Allergy | pmid:9860239 |
| Chihara J et al. | Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). | 1998 | Ann. Allergy Asthma Immunol. | pmid:9860039 |
| Sharif NA et al. | Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9856766 |
| Stamatiou P et al. | 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. | 1998 | J. Clin. Invest. | pmid:9854052 |
| Gardner JP and Zhang L | Glucocorticoid modulation of Ca2+ homeostasis in human B lymphoblasts. | 1999 | J. Physiol. (Lond.) | pmid:9852321 |
| Reiner O and Sapir T | Abnormal cortical development; towards elucidation of the LIS1 gene product function (review). | 1998 | Int. J. Mol. Med. | pmid:9852306 |
| Reverdiau-Moalic P et al. | Human allogeneic lymphocytes trigger endothelial cell tissue factor expression by a tumor necrosis factor-dependent pathway. | 1998 | J. Lab. Clin. Med. | pmid:9851744 |