Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Page CP et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857401 |
| Gresele P et al. | Platelets and asthma. | 1985 | Lancet | pmid:2857402 |
| Lenihan DJ et al. | Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. | 1985 | Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. | pmid:2861063 |
| Braquet P et al. | Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021. | 1985 | Lancet | pmid:2861423 |
| McIntyre TM et al. | Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. | 1985 | J. Clin. Invest. | pmid:2862164 |
| Archer CB et al. | Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. | 1985 | Br. J. Pharmacol. | pmid:2862936 |
| Malone B et al. | Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. | 1985 | J. Biol. Chem. | pmid:3918041 |
| Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
| Valone FH and Johnson B | Modulation of cytoplasmic calcium in human platelets by the phospholipid platelet-activating factor 1-O-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine. | 1985 | J. Immunol. | pmid:2578151 |
| Benveniste J | Biosynthesis and function of PAF-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936197 |
| Kertscher HP and Ostermann G | [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. | 1985 | Pharmazie | pmid:3991788 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Waku K et al. | Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936199 |
| Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
| Saito K et al. | Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936200 |
| Tamargo J et al. | Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. | 1985 | Eur. J. Pharmacol. | pmid:3996472 |
| Hanahan DJ et al. | Platelet-activating factor: a unique lipid chemical mediator. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936201 |
| Terashita Z et al. | Is platelet activating factor (PAF) a mediator of endotoxin shock? | 1985 | Eur. J. Pharmacol. | pmid:3996473 |
| Inoue K et al. | Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2936203 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Verstraete M et al. | An overview of antiplatelet and antithrombotic drugs. | 1985 | Haemostasis | pmid:3159632 |
| Ohno M et al. | An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. | 1985 | Chem. Pharm. Bull. | pmid:4017109 |
| O'Neill C et al. | Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. | 1985 | J In Vitro Fert Embryo Transf | pmid:4020241 |
| Heymans F et al. | Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . | 1985 | J. Med. Chem. | pmid:4020830 |
| Brain SD and Williams TJ | Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. | 1985 | Br. J. Pharmacol. | pmid:2416378 |
| Touqui L et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. | 1985 | Biochim. Biophys. Acta | pmid:3967037 |
| Weber N and Benning H | Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. | 1985 | Eur. J. Biochem. | pmid:3967662 |
| O'Neill C | Partial characterization of the embryo-derived platelet-activating factor in mice. | 1985 | J. Reprod. Fertil. | pmid:4067921 |
| Mallet AI and Cunningham FM | Structural identification of platelet activating factor in psoriatic scale. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970690 |
| Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
| Parente L et al. | The release of lyso-PAF from guinea-pig lungs. | 1985 | Eur. J. Pharmacol. | pmid:4029263 |
| Lee TC | Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. | 1985 | J. Biol. Chem. | pmid:4030776 |
| Wissner A et al. | Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. | 1985 | J. Med. Chem. | pmid:4032422 |
| Pritchard PH et al. | The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). | 1985 | Blood | pmid:4063532 |
| Wissner A et al. | Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. | 1985 | J. Med. Chem. | pmid:4032438 |
| Wimberly HC et al. | Functional and biochemical characterization of immunologically derived equine platelet-activating factor. | 1985 | Vet. Pathol. | pmid:4035942 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. | 1985 | Arch. Biochem. Biophys. | pmid:4037794 |
| Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
| Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Fouque F and Vargaftig BB | Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. | 1985 | J Pharmacol | pmid:4094442 |
| Oda M et al. | Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. | 1985 | J. Immunol. | pmid:3917470 |
| Bergelson LD et al. | Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. | 1985 | FEBS Lett. | pmid:4043408 |
| Kilpatrick JM and Virella G | Inhibition of platelet-activating factor by rabbit C-reactive protein. | 1985 | Clin. Immunol. Immunopathol. | pmid:4042435 |
| Vigo C | Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. | 1985 | J. Biol. Chem. | pmid:3919022 |
| Sugiura T and Waku K | CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3919727 |
| O'Flaherty JT | Neutrophil degranulation: evidence pertaining to its mediation by the combined effects of leukotriene B4, platelet-activating factor, and 5-HETE. | 1985 | J. Cell. Physiol. | pmid:2981891 |
| Khan SN et al. | Desaggregation of PAF-acether-aggregated platelets by verapamil and TMB-8 with reversal of phosphorylation of 40K and 20K proteins. | 1985 | Eur. J. Pharmacol. | pmid:3920056 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |