Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li X and Luo H | [Advances in pharmacological study of Piper kadsura (Choisy) Ohwi]. | 2002 | Zhong Yao Cai | pmid:14748373 |
| Sibelius U et al. | Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. | 2002 | Crit. Care Med. | pmid:12394960 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| Barbuti A et al. | Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003807 |
| Kolaczkowska E et al. | Early vascular permeability in murine experimental peritonitis is co-mediated by resident peritoneal macrophages and mast cells: crucial involvement of macrophage-derived cysteinyl-leukotrienes. | 2002 | Inflammation | pmid:11989789 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
| Parker MA et al. | Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. | 2002 | J. Neurosci. Res. | pmid:12111814 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Chang HW et al. | Platelet-activating factor acetylhydrolase activity in cerebrospinal fluid of children with acute systemic or neurological illness. | 2002 | Ann. Neurol. | pmid:12112082 |
| Ewer AK | Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. | 2002 | Acta Paediatr Suppl | pmid:12200892 |
| Göggel R et al. | Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:12204861 |
| Bazan H and Ottino P | The role of platelet-activating factor in the corneal response to injury. | 2002 | Prog Retin Eye Res | pmid:12207945 |
| Teather LA et al. | Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures. | 2002 | Brain Res. | pmid:12133598 |
| De Plaen IG et al. | Endotoxin, but not platelet-activating factor, activates nuclear factor-kappaB and increases IkappaBalpha and IkappaBbeta turnover in enterocytes. | 2002 | Immunology | pmid:12153521 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
| Sakai H et al. | Nitric oxide-induced Cl- secretion in isolated rat colon is mediated by the release of thromboxane A2. | 2002 | J. Physiol. (Lond.) | pmid:12181297 |
| Roudebush WE et al. | Embryonic platelet-activating factor: temporal expression of the ligand and receptor. | 2002 | J. Assist. Reprod. Genet. | pmid:11958508 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Ottino P et al. | Platelet-activating factor induces the gene expression of TIMP-1, -2, and PAI-1: imbalance between the gene expression of MMP-9 and TIMP-1 and -2. | 2002 | Exp. Eye Res. | pmid:12014920 |
| Michalis LK et al. | Platelet hyperaggregability to platelet activating factor (PAF) in non-ST elevation acute coronary syndromes. | 2002 | Curr Med Res Opin | pmid:12017208 |
| Zimmerman GA et al. | The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis. | 2002 | Crit. Care Med. | pmid:12004251 |
| Silva AR et al. | Monocyte chemoattractant protein-1 and 5-lipoxygenase products recruit leukocytes in response to platelet-activating factor-like lipids in oxidized low-density lipoprotein. | 2002 | J. Immunol. | pmid:11937571 |
| Tachibana A et al. | Respiratory syncytial virus enhances the expression of CD11b molecules and the generation of superoxide anion by human eosinophils primed with platelet-activating factor. | 2002 | Intervirology | pmid:11937770 |
| Kingston JK et al. | Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. | 2002 | Am. J. Vet. Res. | pmid:11939312 |
| Deo DD et al. | Phosphorylation of STAT-3 in response to basic fibroblast growth factor occurs through a mechanism involving platelet-activating factor, JAK-2, and Src in human umbilical vein endothelial cells. Evidence for a dual kinase mechanism. | 2002 | J. Biol. Chem. | pmid:11940567 |
| Strait RT et al. | Pathways of anaphylaxis in the mouse. | 2002 | J. Allergy Clin. Immunol. | pmid:11941316 |
| Xu N et al. | Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944906 |
| Downing SJ et al. | Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? | 2002 | Reproduction | pmid:12361471 |
| Donnard M et al. | Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. | 2002 | Stem Cells | pmid:12351810 |
| Leung SW et al. | Platelet-activating factor enhanced the pressor response of endothelin-1. | 2002 | J. Cardiovasc. Pharmacol. | pmid:12352314 |
| Brewer C et al. | Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. | 2002 | J. Neurochem. | pmid:12354298 |
| Marin V et al. | Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. | 2002 | Eur. J. Immunol. | pmid:12355450 |
| Beauchamp MH et al. | Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. | 2002 | Invest. Ophthalmol. Vis. Sci. | pmid:12356842 |
| Michibayashi T | Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. | 2002 | Int Angiol | pmid:12384648 |
| Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
| Shigematsu S et al. | Bradykinin-induced proinflammatory signaling mechanisms. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388246 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Murohisa G et al. | Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. | 2002 | Liver | pmid:12390475 |
| Maniscalco M et al. | Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. | 2002 | Eur. J. Clin. Invest. | pmid:12423328 |
| Ishii S et al. | Platelet-activating factor receptor. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12432946 |
| Ueyama Y et al. | Effects of bile acids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced aberrant crypt foci and DNA adduct formation in the rat colon. | 2002 | J. Exp. Clin. Cancer Res. | pmid:12636105 |
| Sakai H et al. | E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl- secretion induced by platelet-activating factor in isolated rat colon. | 2002 | Br. J. Pharmacol. | pmid:12023941 |
| Breschi MC et al. | Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. | 2002 | Eur. J. Pharmacol. | pmid:11864645 |
| Tanaka Y et al. | Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor. | 2002 | J. Autoimmun. | pmid:11869042 |
| Talvani A et al. | Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. | 2002 | Infect. Immun. | pmid:12117933 |
| Hanada K et al. | Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy. | 2002 | J. Exp. Med. | pmid:11781362 |
| Fonteh AN | Differential effects of arachidonoyl trifluoromethyl ketone on arachidonic acid release and lipid mediator biosynthesis by human neutrophils. Evidence for different arachidonate pools. | 2002 | Eur. J. Biochem. | pmid:12153573 |
| Ohshima N et al. | Receptor-dependent metabolism of platelet-activating factor in murine macrophages. | 2002 | J. Biol. Chem. | pmid:11786559 |
| Stangl V et al. | Negative inotropic mediators released from the heart after myocardial ischaemia-reperfusion. | 2002 | Cardiovasc. Res. | pmid:11744010 |
| Cheminade C et al. | 1-O-alkylglycerols improve boar sperm motility and fertility. | 2002 | Biol. Reprod. | pmid:11804958 |
| Walterscheid JP et al. | Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression. | 2002 | J. Exp. Med. | pmid:11805144 |
| Unno N et al. | Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. | 2002 | Ann. Surg. | pmid:11807372 |
| Johansson S et al. | A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. | 2002 | J. Nat. Prod. | pmid:11809061 |
| Nagase T et al. | Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11790655 |
| Roudebush WE et al. | Relationship between platelet-activating factor concentration in rhesus monkey (Macaca mulatta) spermatozoa and sperm motility. | 2002 | Am. J. Primatol. | pmid:11793409 |
| Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |
| McKenna DJ et al. | Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications. | 2001 Sep-Oct | Altern Ther Health Med | pmid:11565403 |
| de Souza LJ et al. | Effect of platelet-activating factor antagonists (BN-52021, WEB-2170, and BB-882) on bacterial translocation in acute pancreatitis. | 2001 Jul-Aug | J. Gastrointest. Surg. | pmid:11985976 |
| Coker A et al. | Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice? | 2001 Jul-Aug | Hepatogastroenterology | pmid:11490817 |
| Dery RE et al. | Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). | 2001 Jan-Mar | Int. Arch. Allergy Immunol. | pmid:11306968 |
| Iwazaki S et al. | FR128998 ameliorates liver injury in extended liver resection with ischemia in dogs. | 2001 Jan-Feb | Hepatogastroenterology | pmid:11268964 |
| Magai RM and Shukla SD | Metabolic fate of [14C]-ethanol into endothelial cell phospholipids including platelet-activating factor, sphingomyelin and phosphatidylethanol. | 2001 Jan-Feb | J. Biomed. Sci. | pmid:11173988 |
| Denizot Y et al. | Is there a role of platelet-activating factor in human lung cancer? | 2001 Aug-Sep | Lung Cancer | pmid:11551414 |
| Jolly S et al. | Effect of intravenous platelet-activating factor on bovine pulmonary mast cells. | 2001 Aug-Oct | J. Comp. Pathol. | pmid:11578122 |
| Marathe GK et al. | Oxidized LDL contains inflammatory PAF-like phospholipids. | 2001 Apr-May | Trends Cardiovasc. Med. | pmid:11686003 |
| Taylor R et al. | Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. | 2001 | Clin. Sci. | pmid:11352774 |
| Hayashi J et al. | Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. | 2001 | Nephron | pmid:11287764 |
| Choi JH et al. | Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. | 2001 | J. Immunol. | pmid:11290796 |
| Marathe GK et al. | Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. | 2001 | J. Lipid Res. | pmid:11290831 |
| Kato M et al. | Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. | 2001 | J Ocul Pharmacol Ther | pmid:11327052 |
| Caplan MS et al. | Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. | 2001 | Pediatr. Res. | pmid:11328947 |
| Bassi F et al. | Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. | 2001 | J. Periodontol. | pmid:11210074 |
| Ferland C et al. | Eotaxin promotes eosinophil transmigration via the activation of the plasminogen-plasmin system. | 2001 | J. Leukoc. Biol. | pmid:11358986 |
| Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
| Clavijo LC et al. | PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. | 2001 | J. Appl. Physiol. | pmid:11133918 |
| Ko TC et al. | Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. | 2001 | Bioorg. Med. Chem. Lett. | pmid:11212091 |
| Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
| McManus LM et al. | Agonist-dependent failure of neutrophil function in diabetes correlates with extent of hyperglycemia. | 2001 | J. Leukoc. Biol. | pmid:11527989 |
| Jerkić M et al. | The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. | 2001 | Int Urol Nephrol | pmid:11989542 |
| Kawaguchi A et al. | Preventive effect of platelet-activating factor antagonist, Y-24180, against cyclosporine-induced acute nephrotoxicity. | 2001 | Life Sci. | pmid:11228102 |
| Caplan MS and Jilling T | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. | 2001 | Lipids | pmid:11724457 |
| Kaul DK et al. | Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. | 2001 | Blood | pmid:11698300 |
| Casao MA et al. | Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies. | 2001 | J. Med. Microbiol. | pmid:11699593 |
| Lendvai B et al. | Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. | 2001 | Neurochem. Res. | pmid:11699928 |
| Houghton TJ et al. | Efficient assembly of the phomactin core via two different macrocyclization protocols. | 2001 | Org. Lett. | pmid:11700095 |
| Adams JM et al. | Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. | 2001 | Crit. Care Med. | pmid:11700422 |
| Stoddart NR et al. | Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. | 2001 | Zygote | pmid:11510473 |
| Feldman C et al. | Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. | 2001 | Eur. Respir. J. | pmid:11510782 |
| Mooren FC et al. | Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise. | 2001 | Int J Sports Med | pmid:11510867 |
| Hermoso M et al. | Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. | 2001 | Pflugers Arch. | pmid:11484763 |
| Sachais BS | Platelet-endothelial interactions in atherosclerosis. | 2001 | Curr Atheroscler Rep | pmid:11487452 |
| Jantan I et al. | Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. | 2001 | Planta Med. | pmid:11488464 |
| Thomet OA et al. | Role of petasin in the potential anti-inflammatory activity of a plant extract of petasites hybridus. | 2001 | Biochem. Pharmacol. | pmid:11286996 |
| Burke JR et al. | BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. | 2001 | J. Pharmacol. Exp. Ther. | pmid:11408565 |
| Shah BH et al. | Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. | 2001 | Exp. Mol. Med. | pmid:11795484 |
| Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
| den Dekker E et al. | Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. | 2001 | Thromb. Haemost. | pmid:11686331 |