Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Madi S et al. | Allergen-induced bronchospasm in passively sensitized guinea pigs: influence of new substances in comparison to reference compounds. | 1991 | Agents Actions | pmid:2058463 |
| Braquet P and Esanu A | New trends in PAF antagonist research: a new series of potent hetrapazine-derived PAF antagonists. | 1991 | Agents Actions | pmid:2058466 |
| Northover AM | Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro. | 1990 | Agents Actions | pmid:2111079 |
| Will PC et al. | Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat. | 1991 | Agents Actions | pmid:1793026 |
| Vincent D et al. | Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig. | 1991 | Agents Actions | pmid:1793031 |
| McLeod J et al. | Effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) on substance P-induced histamine release from rat peritoneal mast cells. | 1990 | Agents Actions | pmid:1695435 |
| Desai S and Barton R | Role of platelet activating factor in the pathogenesis of active and passive models of experimental allergic encephalomyelitis in the rat. | 1990 | Agents Actions | pmid:2285021 |
| Adolfs MJ et al. | PAF-acether modifies human peritoneal macrophage cAMP levels in a biphasic fashion. | 1989 | Agents Actions | pmid:2540635 |
| Neumann M and Kownatzki E | The effect of adherence on the generation of reactive oxygen species by human neutrophilic granulocytes. | 1989 | Agents Actions | pmid:2540640 |
| Trebien HA and Calixto JB | Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom. | 1989 | Agents Actions | pmid:2660497 |
| Bekemeier H and Sänze JU | Vasodepression ex vivo after administration of inflammatory mediators in vivo in the rat. | 1989 | Agents Actions | pmid:2476918 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Sanchez Crespo M and Nieto ML | Modulation of PAF biosynthesis in human polymorphonuclear leukocytes. The role of phorbol esters and protein kinases. | 1989 | Agents Actions | pmid:2711927 |
| Zijlstra FJ et al. | The effects of PAF-acether and FMLP on eicosanoid production in guinea pig alveolar macrophages. | 1989 | Agents Actions | pmid:2711928 |
| Nijkamp FP et al. | Role of platelet activating factor in the endotoxin induced tracheal hyperreactivity to histamine in the guinea pig. | 1989 | Agents Actions | pmid:2711929 |
| Oliver JL et al. | Effect of PAF acether on oriented egg phosphatidylcholine multibilayers; interaction with cholesterol; comparison to lyso-PC and lyso-PAF. | 1989 | Agents Actions | pmid:2711930 |
| Howat DW et al. | An investigation into the possible involvement of platelet activating factor in experimental allergic encephalomyelitis in rats. | 1989 | Agents Actions | pmid:2801340 |
| Appleby P and Bowen JG | Cutaneous inflammatory disorders. | 1990 | Agents Actions | pmid:2117335 |
| Lundgren JD et al. | Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: involvement of the lipoxygenase pathway. | 1990 | Agents Actions | pmid:2117336 |
| Doyle SA et al. | Further studies on the antinociceptive effects of delta 6-THC-7-oic acid. | 1990 | Agents Actions | pmid:2178317 |
| Nieminen MM et al. | Body temperature modulates the effect of platelet-activating factor (PAF) on airways responsiveness in the rabbit. | 1991 | Agents Actions | pmid:1862740 |
| Jenei B et al. | Hypotensive action of IgG preparations containing aggregates is suppressed by PAF-receptor antagonist BN 52021 and by gadolinium chloride (an agent blocking Kupffer cell function). | 1991 | Agents Actions | pmid:1862750 |
| Kantar A et al. | Effect of PAF on erythrocyte membrane heterogeneity: a fluorescence study. | 1991 | Agents Actions | pmid:1862752 |
| Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
| Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Carlson RP et al. | Pharmacologic modulation of PAF-induced mortality in mice. | 1987 | Agents Actions | pmid:3120513 |
| Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Cunha FQ et al. | Failure of PAF-acether to induce in vivo neutrophil migration. | 1988 | Agents Actions | pmid:3055873 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
| Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
| Mastacchi R et al. | Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. | 1986 | Agents Actions | pmid:3518359 |
| Kusner EJ et al. | Pharmacologic analysis of 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced increases in cutaneous vascular permeability in the rat. | 1987 | Agents Actions | pmid:3577957 |
| Pettipher ER et al. | PAF-acether in chronic arthritis. | 1987 | Agents Actions | pmid:3630862 |
| Archer CB et al. | Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. | 1985 | Agents Actions | pmid:3923788 |
| Parente L et al. | The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. | 1986 | Agents Actions | pmid:3962774 |
| Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
| Pirotzky E et al. | Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. | 1985 | Agents Actions | pmid:4003192 |
| Page CP et al. | Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. | 1985 | Agents Actions | pmid:4003195 |
| Page CP et al. | Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. | 1985 | Agents Actions | pmid:4003196 |
| Spicer BA et al. | An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. | 1985 | Agents Actions | pmid:4003197 |
| Boughton-Smith NK et al. | Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. | 1992 | Agents Actions | pmid:1279960 |
| Perales J et al. | Neutralization of the oedematogenic activity of Bothrops jararaca venom on the mouse paw by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum. | 1992 | Agents Actions | pmid:1295374 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor. | 1992 | Agents Actions | pmid:1414679 |
| Tran A et al. | Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. | 1992 | Agents Actions | pmid:1414687 |
| Northover AM | In vitro effects of PAF on venous endothelial cell actin disposition. | 1992 | Agents Actions | pmid:1509977 |
| Okamoto H et al. | Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. | 1992 | Agents Actions | pmid:1388318 |
| Miyagawa H et al. | The effect of WEB 2086 on PAF-induced eosinophil chemotaxis and LTC4 production from eosinophils. | 1992 | Agents Actions | pmid:1456179 |
| Rachmilewitz D et al. | Cytokines and platelet-activating factor in human inflamed colonic mucosa. | 1992 | Agents Actions | pmid:1359744 |
| Ogunbiyi PO and Eyre P | Pharmacological studies of pulmonary anaphylaxis in vitro: a review. | 1985 | Agents Actions | pmid:2420161 |
| Lewis AJ et al. | The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. | 1984 | Agents Actions | pmid:6152379 |
| Benveniste J | Platelet-activating factor (PAF-acether): present status. | 1981 | Agents Actions | pmid:6176101 |
| Northover AM and Northover BJ | Lectin-induced increase in microvascular permeability to colloidal carbon in vitro may involve protein kinase C activation. | 1994 | Agents Actions | pmid:7942320 |
| Tubaro E et al. | In vitro and in vivo impact of a new glycosphingolipid on neutrophils. | 1994 | Agents Actions | pmid:7879694 |
| Canale P et al. | TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock. | 1994 | Agents Actions | pmid:7879698 |
| Raff GW et al. | Procoagulant property of platelet activating factor (PAF). | 1993 | Agents Actions | pmid:8273543 |
| Meats JE et al. | Identification of phospholipase D (PLD) activity in mouse peritoneal macrophages. | 1993 | Agents Actions | pmid:8273553 |
| Thomas TK et al. | Differential antagonism of platelet activating factor-induced neutrophilia and gastric hemorrhage in the rat. | 1993 | Agents Actions | pmid:8273566 |
| Glaser KB et al. | Pharmacological characterization of WAY-121,520: a potent anti-inflammatory indomethacin-based inhibitor of 5-lipoxygenase (5-LO)/phospholipase A2 (PLA2). | 1993 | Agents Actions | pmid:8273577 |
| Kantar A et al. | Effect of PAF on human lymphocyte membranes: a fluorescence study. | 1993 | Agents Actions | pmid:8317302 |
| Boonen GJ et al. | Activation of neutrophil migration by dioctanoyl-sn-glycerol and fMet-Leu-Phe is controlled by different pathways. | 1993 | Agents Actions | pmid:8317308 |
| Murphy G | Report of the 14th meeting of the British Inflammation Research Association. Topic: cellular and molecular aspects of inflammatory bowel disease. | 1993 | Agents Actions | pmid:8480529 |
| Sakamoto T et al. | Effect of beta 2-adrenoceptor agonists against platelet-activating factor-induced airway microvascular leakage and bronchoconstriction in the guinea pig. | 1993 | Agents Actions | pmid:7908496 |
| Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| Lecrubier C et al. | Study of platelet aggregation induced by platelet activating factor (PAF) after administration of ticlopidine or aspirin. | 1983 | Agents Actions | pmid:6858789 |
| Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
| Caillard CG et al. | Hypotensive activity of PAF-acether in rats. | 1982 | Agents Actions | pmid:6299079 |
| Mencia-Huerta JM et al. | Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? | 1981 | Agents Actions | pmid:7053072 |
| Vargaftig BB | Platelet-activating factor (PAF-acether) | 1982 | Agents Actions | pmid:7164939 |
| Bette P and Bienvenue A | Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. | 1982 | Agents Actions | pmid:7164940 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of PAF-acether. Preliminary results after the intravenous administration of a 3H-labelled product to the rabbit. | 1982 | Agents Actions | pmid:7164941 |
| Morgat JL et al. | Radio-labelling of 1-O-alkyl, 2-O-acetyl, sn-glycero-3-phosphorylcholine, 1-O-(9,10-di3H)-octadecyl PAF-acether. | 1982 | Agents Actions | pmid:7164942 |
| Convert O et al. | 1H NMR of PAF-acether: influence of solvent on its structure. | 1982 | Agents Actions | pmid:7164943 |
| Borrel MC et al. | Additional techniques for the total synthesis of PAF-acether. | 1982 | Agents Actions | pmid:7164944 |
| Benveniste J et al. | Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types. | 1982 | Agents Actions | pmid:7164945 |
| Arnoux B et al. | Release of PAF-acether from human blood monocytes. | 1982 | Agents Actions | pmid:7164946 |
| Fouque F et al. | Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action. | 1982 | Agents Actions | pmid:7164947 |
| Lefort J et al. | Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. | 1982 | Agents Actions | pmid:7164948 |
| Vargaftig BB et al. | Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). | 1980 | Agents Actions | pmid:7270336 |
| Bonnet J et al. | Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes. | 1981 | Agents Actions | pmid:7340441 |
| Denjean A et al. | Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. | 1981 | Agents Actions | pmid:7340444 |
| Heller R et al. | S35b, a new phenylsulfonylfuroxan compound, inhibits thrombin-induced synthesis of platelet-activating factor and prostacyclin in human endothelial cells. | 1993 | Agents Actions | pmid:7517616 |
| Louis R et al. | Potentiation of histamine release from human leucocytes by PAF. | 1994 | Agents Actions | pmid:7521570 |
| Izzo AA et al. | Platelet activating factor potentiates rat paw oedema induced by different phlogogen agents. | 1994 | Agents Actions | pmid:7524288 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Czarnetzki BM and Benveniste J | Effect of synthetic PAF-acether on human neutrophil function. | 1981 | Agents Actions | pmid:7041568 |
| Camussi G et al. | Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). | 1981 | Agents Actions | pmid:7041569 |
| de Bernardis E et al. | Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema. | 1994 | Agents Actions | pmid:7847181 |
| Kelefiotis D and Vakirtzi-Lemonias C | In vivo responses of mouse blood cells to platelet-activating factor (PAF): role of the mediators of anaphylaxis. | 1993 | Agents Actions | pmid:8023738 |
| Northover AM and Northover BJ | Involvement of protein kinase C in the control of microvascular permeability to colloidal carbon. | 1993 | Agents Actions | pmid:8304240 |
| Page CP et al. | Drugs affecting pulmonary responses to platelet activating factor as novel anti-asthma drugs. | 1988 | Agents Actions Suppl. | pmid:3051932 |
| Szczeklik A et al. | Bleeding time and PAF-acether-induced platelet aggregation in atopy. | 1987 | Agents Actions Suppl. | pmid:3478996 |
| Page CP and Robertson DN | Properties of PAF relevant to asthma. | 1987 | Agents Actions Suppl. | pmid:3314416 |