Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Melanoma D008545 69 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Reperfusion Injury D015427 65 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Nerve Degeneration D009410 53 associated lipids
Asthma D001249 52 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Osteosarcoma D012516 50 associated lipids
Thrombosis D013927 49 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Nervous System Diseases D009422 37 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Fever D005334 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Burns D002056 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Uremia D014511 33 associated lipids
Memory Disorders D008569 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Proteinuria D011507 30 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Neuralgia D009437 28 associated lipids
Gastritis D005756 27 associated lipids
Endotoxemia D019446 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Brain Diseases D001927 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Ascites D001201 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Lenihan DJ et al. Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis. 1985 Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. pmid:2861063
Braquet P et al. Involvement of platelet activating factor in respiratory anaphylaxis, demonstrated by PAF-acether inhibitor BN 52021. 1985 Lancet pmid:2861423
McIntyre TM et al. Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. 1985 J. Clin. Invest. pmid:2862164
Archer CB et al. Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. 1985 Br. J. Pharmacol. pmid:2862936
Morris HG Mechanisms of glucocorticoid action in pulmonary disease. 1985 Chest pmid:2410202
Bruynzeel PL et al. Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. 1985 FEBS Lett. pmid:2995125
Doebber TW et al. Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. 1985 Biochem. Biophys. Res. Commun. pmid:2985058
Bourgain RH et al. The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. 1985 Prostaglandins pmid:3931178
Ribbes G et al. Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. 1985 FEBS Lett. pmid:3932094
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Barnes PJ Mediators and asthma. 1985 Br J Hosp Med pmid:3936563
Hemmendinger S et al. [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. 1985 Arch Mal Coeur Vaiss pmid:3938941
Iñarrea P et al. Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. 1985 Immunopharmacology pmid:3886598
Lellouch-Tubiana A et al. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. 1985 Br J Exp Pathol pmid:3890915
Weber N and Mangold HK Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. 1985 J. Lipid Res. pmid:3891896
Maes L et al. In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. 1985 Adv. Exp. Med. Biol. pmid:3832867
Hanahan DJ et al. Platelet-activating factor: a unique lipid chemical mediator. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936201
Tuffin DP et al. Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. 1985 Adv. Exp. Med. Biol. pmid:3834789
Inoue K et al. Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936203
Parente L and Flower RJ Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes. 1985 Life Sci. pmid:3838566
Kumar R et al. Occurrence of glyceryl ethers in the phosphatidylcholine fraction of surfactant from dog lungs. 1985 Biochim. Biophys. Acta pmid:3839684
Tokumura A and Tsukatani H [Antagonists of platelet activating factor]. 1985 Seikagaku pmid:3009656
MacIntyre DE et al. Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. 1985 Adv. Exp. Med. Biol. pmid:3010662
Hallam TJ et al. Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. 1985 Adv. Exp. Med. Biol. pmid:3010663
Teng CM et al. Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. 1985 Biochim. Biophys. Acta pmid:3926005
Ostermann G et al. Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. 1985 Biomed. Biochim. Acta pmid:4004829
Touqui L et al. Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. 1985 Biochem. J. pmid:4052028
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Benveniste J Paf-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3159192
Detsouli A et al. Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. 1985 Br. J. Pharmacol. pmid:4005486
Korth R et al. Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. 1985 Chem. Phys. Lipids pmid:4006034
Verstraete M et al. An overview of antiplatelet and antithrombotic drugs. 1985 Haemostasis pmid:3159632
Apprill P et al. Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. 1985 Circulation pmid:2988822
Zimmerman GA et al. Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. 1985 Circulation pmid:3928193
Benveniste J and Chignard M A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? 1985 Circulation pmid:3928192
Ogunbiyi PO and Eyre P Pharmacological studies of pulmonary anaphylaxis in vitro: a review. 1985 Agents Actions pmid:2420161
Kozlov VK et al. [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. 1985 Biull Eksp Biol Med pmid:4052603
Page CP et al. Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. 1985 Int J Tissue React pmid:4055261
Wardlow ML Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. 1985 J. Chromatogr. pmid:4055961
Hubbard JW et al. Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. 1985 Res. Commun. Chem. Pathol. Pharmacol. pmid:4059660
Imbs AB et al. [Synthesis of a fluorescently-labeled platelet activating factor]. 1985 Bioorg. Khim. pmid:4062993
Tokumura A et al. Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. 1985 J. Chromatogr. pmid:4066848
Meloni Bruneri LH and Barbieri D [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. 1985 Sangre (Barc) pmid:4071355
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Mushayakarara EC and Mantsch HH Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. 1985 Can. J. Biochem. Cell Biol. pmid:4075223
Vanhoutte PM and Houston DS Platelets, endothelium, and vasospasm. 1985 Circulation pmid:3861273
Weisman SM et al. Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. 1985 J. Pharmacol. Exp. Ther. pmid:3862805
Morley J et al. PAF and airway hyperreactivity. 1985 Lancet pmid:2863479
Morley J et al. Platelets in asthma. 1985 Lancet pmid:2863708
Cox CP Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). 1985 Comp Biochem Physiol A Comp Physiol pmid:2864195