Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
Doublier S et al. | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. | 2007 | Clin. Cancer Res. | pmid:17908960 |
Shimada T et al. | Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. | 2007 | J. Endocrinol. | pmid:17911394 |
Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
Witzenrath M et al. | Role of platelet-activating factor in pneumolysin-induced acute lung injury. | 2007 | Crit. Care Med. | pmid:17522574 |
Keles GC et al. | Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. | 2007 | Clin Oral Investig | pmid:17522901 |
Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
Tosaki T et al. | Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. | 2007 | Biol. Pharm. Bull. | pmid:17268064 |
Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
Sandford RM et al. | The genetic basis of abdominal aortic aneurysms: a review. | 2007 | Eur J Vasc Endovasc Surg | pmid:17276705 |
Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
Dupré DJ et al. | Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. | 2007 | Cell. Signal. | pmid:17609120 |
Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
Dunkel B et al. | Platelet activation in ponies with airway inflammation. | 2007 | Equine Vet. J. | pmid:18065316 |
Lu SM et al. | The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. | 2007 | J Neuroimmune Pharmacol | pmid:18040844 |
Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
Tsoupras AB et al. | Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | 2007 | Mediators Inflamm. | pmid:17710109 |
Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |
Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
Saluk-Juszczak J et al. | The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. | 2007 | Curr. Microbiol. | pmid:17160361 |
Huang YH et al. | Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. | 2007 | J. Cell. Biochem. | pmid:17131380 |
Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
Fragopoulou E et al. | Biological activity of acetylated phenolic compounds. | 2007 | J. Agric. Food Chem. | pmid:17199317 |
Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |