Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Seizures D012640 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Melanoma D008545 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Reperfusion Injury D015427 65 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Weight Loss D015431 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Nerve Degeneration D009410 53 associated lipids
Asthma D001249 52 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Osteosarcoma D012516 50 associated lipids
Thrombosis D013927 49 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hyperalgesia D006930 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Nervous System Diseases D009422 37 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Fever D005334 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Burns D002056 34 associated lipids
Memory Disorders D008569 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Acute Lung Injury D055371 33 associated lipids
Uremia D014511 33 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Proteinuria D011507 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Neuralgia D009437 28 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gastritis D005756 27 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Endotoxemia D019446 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Brain Diseases D001927 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Ascites D001201 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Boetkjaer A et al. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. 2007 Neurosci. Lett. pmid:17881124
Xu W et al. Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. 2007 Chin. Med. J. pmid:18028783
Keam SJ and Plosker GL Rupatadine: a review of its use in the management of allergic disorders. 2007 Drugs pmid:17335300
Van Overloop H et al. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. 2007 Biol. Chem. pmid:17338639
Cui S et al. L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17395449
Roudebush WE Seminal platelet-activating factor. 2007 Semin. Thromb. Hemost. pmid:17253192
Wang S et al. Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. 2007 Chin. Med. J. pmid:17543178
Kulkarni S et al. Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. 2007 Blood pmid:17548580
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Paterson WG et al. Role of platelet-activating factor in acid-induced esophageal mucosal injury. 2007 Dig. Dis. Sci. pmid:17415649
Tsimikas S et al. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17626905
Li Y et al. Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. 2007 Biol. Reprod. pmid:17634444
Nagi-Miura N et al. Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. 2007 Biol. Pharm. Bull. pmid:17603181
Kooyman FN et al. Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. 2007 Infect. Immun. pmid:17606606
Dupré DJ et al. Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. 2007 Cell. Signal. pmid:17609120
Huang QY and Li MJ [Effect of platelet-activating factor on sperm function]. 2007 Zhonghua Nan Ke Xue pmid:17615981
Orr Y et al. Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. 2007 J. Leukoc. Biol. pmid:17675559
Bozlu G et al. Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. 2007 Brain Res. pmid:17320823
Wang J et al. Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. 2007 Int. J. Cardiol. pmid:16887214
Bock J et al. Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. 2007 World J. Gastroenterol. pmid:17876892
Ryan SD et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. 2007 J. Neurochem. pmid:17877634
Madsen NJ et al. Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. 2007 Am. J. Cardiol. pmid:17697836
Takahashi T et al. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. 2007 Microvasc. Res. pmid:17027041
Huang GD et al. [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. 2007 Zhong Yao Cai pmid:18422199
Callender HL et al. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. 2007 Anal. Chem. pmid:17194150
Heusler P and Boehmer G Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. 2007 Brain Res. pmid:17196945
Fragopoulou E et al. Biological activity of acetylated phenolic compounds. 2007 J. Agric. Food Chem. pmid:17199317
Greinacher A Too many hits in HIT? 2007 Am. J. Hematol. pmid:17729242
Gui C et al. Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. 2007 Proteins pmid:17243151
Ali A et al. Essential role of platelet-activating factor in male reproduction: a review. 2007 Reprod. Biomed. Online pmid:17298732
Subbotina LA [Procedure of blood agregation system analysis]. 2006 Sep-Oct Aviakosm Ekolog Med pmid:17357632
Givehchi A et al. Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. 2006 May-Jun J Chem Inf Model pmid:16711727
Lang F et al. Osmotic shock-induced suicidal death of erythrocytes. 2006 May-Jun Acta Physiol (Oxf) pmid:16734755
Zhu T et al. Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. 2006 Mar-Apr Can. J. Physiol. Pharmacol. pmid:16902584
Gu Y et al. PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. 2006 Jun-Jul Placenta pmid:16122793
Lang F et al. Mechanisms and significance of eryptosis. 2006 Jul-Aug Antioxid. Redox Signal. pmid:16910766
Vasques E et al. Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. 2006 Jan-Feb Endothelium pmid:16885061
He J and Bazan HE Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16505020
Barthomeuf C et al. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. 2006 Free Radic. Biol. Med. pmid:16458188
Marchand C et al. Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. 2006 J. Cell. Biochem. pmid:16479592
Zhang Q et al. Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. 2006 Exp. Dermatol. pmid:16984258
Hartvigsen K et al. 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. 2006 Lipids pmid:17069352
Sugimoto S et al. Purification and characterization of lysophospholipase D from rat brain. 2006 Biochim. Biophys. Acta pmid:17071136
Machado EM et al. WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. 2006 J. Insect Physiol. pmid:16777137
Blanchet MR et al. Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. 2006 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:16782754
Gomes RN et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. 2006 Shock pmid:16783197
Chen LW et al. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. 2006 Shock pmid:16783201
Poeckel D et al. 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. 2006 J. Pharmacol. Exp. Ther. pmid:16174802
Dohi T et al. [Role of platelet-activating factor on spinal pain transduction]. 2006 Nippon Yakurigaku Zasshi pmid:16508219
Karidis NP et al. Platelet-activating factor in liver injury: a relational scope. 2006 World J. Gastroenterol. pmid:16773686