Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Boetkjaer A et al. | Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. | 2007 | Neurosci. Lett. | pmid:17881124 |
Xu W et al. | Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. | 2007 | Chin. Med. J. | pmid:18028783 |
Keam SJ and Plosker GL | Rupatadine: a review of its use in the management of allergic disorders. | 2007 | Drugs | pmid:17335300 |
Van Overloop H et al. | On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. | 2007 | Biol. Chem. | pmid:17338639 |
Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
Paterson WG et al. | Role of platelet-activating factor in acid-induced esophageal mucosal injury. | 2007 | Dig. Dis. Sci. | pmid:17415649 |
Tsimikas S et al. | New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17626905 |
Li Y et al. | Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. | 2007 | Biol. Reprod. | pmid:17634444 |
Nagi-Miura N et al. | Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. | 2007 | Biol. Pharm. Bull. | pmid:17603181 |
Kooyman FN et al. | Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. | 2007 | Infect. Immun. | pmid:17606606 |
Dupré DJ et al. | Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. | 2007 | Cell. Signal. | pmid:17609120 |
Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
Wang J et al. | Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. | 2007 | Int. J. Cardiol. | pmid:16887214 |
Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
Takahashi T et al. | Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. | 2007 | Microvasc. Res. | pmid:17027041 |
Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
Callender HL et al. | Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. | 2007 | Anal. Chem. | pmid:17194150 |
Heusler P and Boehmer G | Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. | 2007 | Brain Res. | pmid:17196945 |
Fragopoulou E et al. | Biological activity of acetylated phenolic compounds. | 2007 | J. Agric. Food Chem. | pmid:17199317 |
Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
Givehchi A et al. | Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors. | 2006 May-Jun | J Chem Inf Model | pmid:16711727 |
Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
Zhu T et al. | Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. | 2006 Mar-Apr | Can. J. Physiol. Pharmacol. | pmid:16902584 |
Gu Y et al. | PAF levels and PAF-AH activities in placentas from normal and preeclamptic pregnancies. | 2006 Jun-Jul | Placenta | pmid:16122793 |
Lang F et al. | Mechanisms and significance of eryptosis. | 2006 Jul-Aug | Antioxid. Redox Signal. | pmid:16910766 |
Vasques E et al. | Impairment of endothelium-dependent aorta relaxation by phospholipid components of oxidized low-density lipoprotein. | 2006 Jan-Feb | Endothelium | pmid:16885061 |
He J and Bazan HE | Synergistic effect of platelet-activating factor and tumor necrosis factor-alpha on corneal myofibroblast apoptosis. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:16505020 |
Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
Marchand C et al. | Role of MSK1 in the signaling pathway leading to VEGF-mediated PAF synthesis in endothelial cells. | 2006 | J. Cell. Biochem. | pmid:16479592 |
Zhang Q et al. | Activation of platelet-activating factor receptor in SZ95 sebocytes results in inflammatory cytokine and prostaglandin E2 production. | 2006 | Exp. Dermatol. | pmid:16984258 |
Hartvigsen K et al. | 1 -O-alkyl-2-(omega-oxo)acyl-sn-glycerols from shark oil and human milk fat are potential precursors of PAF mimics and GHB. | 2006 | Lipids | pmid:17069352 |
Sugimoto S et al. | Purification and characterization of lysophospholipase D from rat brain. | 2006 | Biochim. Biophys. Acta | pmid:17071136 |
Machado EM et al. | WEB 2086, a platelet-activating factor antagonist, inhibits prophenoloxidase-activating system and hemocyte microaggregation reactions induced by Trypanosoma rangeli infection in Rhodnius prolixus hemolymph. | 2006 | J. Insect Physiol. | pmid:16777137 |
Blanchet MR et al. | Dimethyphenylpiperazinium, a nicotinic receptor agonist, downregulates inflammation in monocytes/macrophages through PI3K and PLC chronic activation. | 2006 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:16782754 |
Gomes RN et al. | Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. | 2006 | Shock | pmid:16783197 |
Chen LW et al. | Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. | 2006 | Shock | pmid:16783201 |
Poeckel D et al. | 3-O-acetyl-11-keto-boswellic acid decreases basal intracellular Ca2+ levels and inhibits agonist-induced Ca2+ mobilization and mitogen-activated protein kinase activation in human monocytic cells. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16174802 |
Dohi T et al. | [Role of platelet-activating factor on spinal pain transduction]. | 2006 | Nippon Yakurigaku Zasshi | pmid:16508219 |
Karidis NP et al. | Platelet-activating factor in liver injury: a relational scope. | 2006 | World J. Gastroenterol. | pmid:16773686 |