Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Inflammation D007249 119 associated lipids
Hypertension D006973 115 associated lipids
Glioma D005910 112 associated lipids
Weight Gain D015430 101 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Brain Ischemia D002545 89 associated lipids
Seizures D012640 87 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Arteriosclerosis D001161 86 associated lipids
Atherosclerosis D050197 85 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Alzheimer Disease D000544 76 associated lipids
Stomach Ulcer D013276 75 associated lipids
Leukemia D007938 74 associated lipids
Coronary Disease D003327 70 associated lipids
Melanoma D008545 69 associated lipids
Colitis D003092 69 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Neuroblastoma D009447 66 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Reperfusion Injury D015427 65 associated lipids
Pain D010146 64 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Parkinson Disease D010300 53 associated lipids
Nerve Degeneration D009410 53 associated lipids
Asthma D001249 52 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Osteosarcoma D012516 50 associated lipids
Thrombosis D013927 49 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Psoriasis D011565 47 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Hyperalgesia D006930 42 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Hypotension D007022 41 associated lipids
Arthritis D001168 41 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Peritonitis D010538 38 associated lipids
Lung Diseases D008171 37 associated lipids
Nervous System Diseases D009422 37 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Fever D005334 35 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Epilepsy D004827 35 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Burns D002056 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Acute Lung Injury D055371 33 associated lipids
Uremia D014511 33 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Memory Disorders D008569 33 associated lipids
Neurodegenerative Diseases D019636 32 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Stroke D020521 32 associated lipids
Cardiomegaly D006332 31 associated lipids
Proteinuria D011507 30 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Neuralgia D009437 28 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Gastritis D005756 27 associated lipids
Endotoxemia D019446 27 associated lipids
Angina Pectoris D000787 27 associated lipids
Hyperinsulinism D006946 27 associated lipids
Brain Diseases D001927 27 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Nasal Polyps D009298 26 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Ascites D001201 25 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Arthritis, Experimental D001169 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Getting SJ et al. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. 1997 J. Pharmacol. Exp. Ther. pmid:9336316
Greiff L et al. Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. 1997 Acta Physiol. Scand. pmid:9338520
Ohashi Y et al. Platelet activating factor compromises airway epithelial defense functions. 1997 J. Allergy Clin. Immunol. pmid:9338547
Hirashima Y et al. Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. 1997 Neurochem. Res. pmid:9342729
Francescangeli E et al. Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. 1997 Neurochem. Res. pmid:9342735
Bastos da Silva M et al. Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. 1997 Sep-Oct Vet. Res. pmid:9342825
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Bastos da Silva MB et al. The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. 1997 Vet. Res. Commun. pmid:9345719
Million M et al. Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. 1997 Eur. J. Pharmacol. pmid:9346330
Aspey BS et al. Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. 1997 Metab Brain Dis pmid:9346472
Bzeizi KI et al. Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. 1997 Liver Transpl Surg pmid:9346727
Denham W et al. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. 1997 Gastroenterology pmid:9352880
Howarth PH Mediators of nasal blockage in allergic rhinitis. 1997 Allergy pmid:9353555
Nagaoka H et al. 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). 1997 Chem. Pharm. Bull. pmid:9353894
Liu B et al. Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. 1997 Biochem. J. pmid:9355758
Silomon M et al. Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. 1997 J. Surg. Res. pmid:9356229
Wang H et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. 1997 Pediatr. Res. pmid:9357930
May JA et al. Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. 1997 Thromb. Res. pmid:9361371
Radonjic-Lazovic G and Roudebush WE The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. 1995 Early Pregnancy pmid:9363251
Hershkowitz M and Adunsky A Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. 1996 Nov-Dec Neurobiol. Aging pmid:9363797
Kishimoto S et al. Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. 1997 Int. Arch. Allergy Immunol. pmid:9363928
Manna SK et al. Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. 1997 J. Immunol. pmid:9366432
Saeed SA et al. Anti-thrombotic and anti-inflammatory activities of protopine. 1997 Pharmacol. Res. pmid:9368908
Snyder F CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. 1997 Biochim. Biophys. Acta pmid:9370322
Nagase T et al. Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. 1997 Am. J. Respir. Crit. Care Med. pmid:9372685
Tetta C et al. Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. 1997 Am. J. Kidney Dis. pmid:9372980
Garland A et al. Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. 1997 Am. J. Physiol. pmid:9374740
Miyahara T et al. Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. 1997 J. Appl. Physiol. pmid:9375313
Bazan HE et al. Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. 1997 Invest. Ophthalmol. Vis. Sci. pmid:9375567
Mori M et al. Localization of platelet-activating factor receptor messenger RNA in the rat eye. 1997 Invest. Ophthalmol. Vis. Sci. pmid:9375587
Okada S et al. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. 1997 Am. J. Respir. Cell Mol. Biol. pmid:9376127
Mantovani A The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. 1997 Drugs pmid:9378074
Kagoshima M et al. Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. 1997 Pharmacology pmid:9380772
Kozai T et al. Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. 1997 Coron. Artery Dis. pmid:9383603
Wang HG et al. Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9384519
Sapir T et al. Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. 1997 EMBO J. pmid:9384577
Yu P et al. [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. 1996 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:9387456
Zhou X et al. [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. 1996 Zhonghua Jie He He Hu Xi Za Zhi pmid:9387483
Cheng D et al. [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. 1996 Hua Xi Yi Ke Da Xue Xue Bao pmid:9389027
Cheng D and Chen W [The role of platelet activating factor in chronic pulmonary hypertension]. 1996 Hua Xi Yi Ke Da Xue Xue Bao pmid:9389061
Hu DH and Ma CT [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. 1996 Sheng Li Xue Bao pmid:9389196
Bellamy MC et al. Changes in inflammatory mediators during orthotopic liver transplantation. 1997 Br J Anaesth pmid:9389852
Nathan N et al. Cytokine and lipid mediator blood concentrations after coronary artery surgery. 1997 Anesth. Analg. pmid:9390587
Im SY et al. Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. 1997 Eur. J. Immunol. pmid:9394802
Negro Alvarez JM et al. Platelet-activating factor antagonists. 1997 Sep-Oct Allergol Immunopathol (Madr) pmid:9395010
Elzi DJ et al. Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. 1997 Biochem. Biophys. Res. Commun. pmid:9398641
el-Shazly AE et al. Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. 1997 Aug-Dec Immunol. Invest. pmid:9399104
Erickson KL et al. Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. 1997 J. Leukoc. Biol. pmid:9400826
Bix GJ and Clark GD Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. 1997 J. Neurosci. Methods pmid:9402559