Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
Michel L et al. | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. | 1988 | J. Allergy Clin. Immunol. | pmid:2899102 |
Michel L et al. | Release of PAF-acether and precursors during allergic cutaneous reactions. | 1988 | Lancet | pmid:2899817 |
Frick KK et al. | Platelet-derived growth factor-induced c-myc RNA expression. Analysis of an inducible pathway independent of protein kinase C. | 1988 | J. Biol. Chem. | pmid:2449430 |
Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
Dillon PK and Durán WN | Effect of platelet-activating factor on microvascular permselectivity: dose-response relations and pathways of action in the hamster cheek pouch microcirculation. | 1988 | Circ. Res. | pmid:2450695 |
Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
Nasmith PE and Grinstein S | Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. | 1988 | Biosci. Rep. | pmid:2840131 |
Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
Neuwirth R et al. | Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. | 1988 | J. Clin. Invest. | pmid:3166467 |
Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
Grue-Sørensen G et al. | Derivatives of 2-methylenepropane-1,3-diol as new antagonists of platelet activating factor. | 1988 | J. Med. Chem. | pmid:3373485 |
Pirotzky E et al. | Protection of platelet-activating factor-induced acute renal failure by BN 52021. | 1988 | Br J Exp Pathol | pmid:3377967 |
Csatò M and Czarnetzki BM | Effect of BN 52021, a platelet activating factor antagonist, on experimental murine contact dermatitis. | 1988 | Br. J. Dermatol. | pmid:3377969 |
Hoffman DR et al. | Platelet-activating factor induces glycogen degradation in fetal rabbit lung in utero. | 1988 | J. Biol. Chem. | pmid:3379072 |
Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
Handley DA et al. | Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3183958 |
Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
Etienne A et al. | Role of neutrophils in gastric damage induced by platelet activating factor. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3244384 |
Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
Ojima-Uchiyama A et al. | Phospholipid analysis of human eosinophils: high levels of alkylacylglycerophosphocholine (PAF precursor). | 1988 | Lipids | pmid:3185116 |
Skeaff CM and Holub BJ | The effect of fish oil consumption on platelet aggregation responses in washed human platelet suspensions. | 1988 | Thromb. Res. | pmid:3187952 |
Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
Taira M et al. | Lack of involvement of leukotriene and platelet activating factor in passive cutaneous anaphylaxis in rats. | 1988 | Agents Actions | pmid:3407549 |
Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
Stahl GL et al. | Salutary consequences of blockade of platelet activating factor in hemorrhagic shock. | 1988 | Eur. J. Pharmacol. | pmid:3409951 |
Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
Masugi F et al. | Platelet-activating factor and anti-platelet-aggregating factor in acute reduction of blood pressure following percutaneous transluminal renal angioplasty in patients with renovascular hypertension. | 1988 | J Hum Hypertens | pmid:2977405 |
Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
Andersson M and Pipkorn U | The effect of platelet activating factor on nasal hypersensitivity. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181276 |
Adamus WS et al. | Inhibitory effect of oral WEB 2086, a novel selective PAF-acether antagonist, on ex vivo platelet aggregation. | 1988 | Eur. J. Clin. Pharmacol. | pmid:3181277 |
Yanoshita R et al. | Hydrolysis of platelet activating factor and its methylated analogs by acetylhydrolases. | 1988 | J. Biochem. | pmid:3182751 |
Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
Whatley RE et al. | The regulation of synthesis of platelet-activating factor by endothelial cells. | 1988 | Chest | pmid:3342689 |
Ukena D et al. | Radioligand binding of antagonists of platelet-activating factor to intact human platelets. | 1988 | FEBS Lett. | pmid:3342883 |
Suzuki Y et al. | Release of acetylhydrolase from platelets on aggregation with platelet-activating factor. | 1988 | Eur. J. Biochem. | pmid:3345757 |
Benveniste J and Leyravaud S | Retention of platelet activating factor by human neutrophils. | 1988 | J. Immunol. | pmid:3346547 |
17th annual UCLA symposium. Abstracts: Cell activation and signal initiation: receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production. | 1988 | J. Cell. Biochem. Suppl. | pmid:2835556 | |
Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
Paulson SK and Nicholson NS | A radioreceptor binding assay for measurement of platelet-activating factor synthesis by human neutrophils. | 1988 | J. Immunol. Methods | pmid:2837517 |
Stahl GL et al. | Role of platelet activating factor in propagation of cardiac damage during myocardial ischemia. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3252036 |
Williams WR et al. | Plates and anti-asthma drugs. | 1988 | Pneumonol Pol | pmid:3254508 |
Archer CB | Mediators of heat urticaria. | 1988 | Clin. Exp. Dermatol. | pmid:3256463 |
Morell GP et al. | Paf-acether (platelet-activating factor) and interleukin-1-like cytokine production by lipopolysaccharide-stimulated glomeruli. | 1988 | Clin. Immunol. Immunopathol. | pmid:3257432 |
Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
Silva PM et al. | Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats. | 1988 | Braz. J. Med. Biol. Res. | pmid:3240383 |
Fichelle J et al. | Bronchospasmolytic effects of RU 42173. | 1988 | Fundam Clin Pharmacol | pmid:3240917 |
Misawa M and Takata T | [Effects of platelet activating factor on the bronchial musculature and vasculature in dogs]. | 1988 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:3241511 |
Yasuda K et al. | Acyl type platelet-activating factor in normal rat uterus determined by gas chromatography mass spectrometry. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242662 |
Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |
Mallet AI | Analysis of lyso-platelet activating factor by negative ion gas chromatography/mass spectrometry of the nitrobenzal acetal derivatives. | 1988 | Biomed. Environ. Mass Spectrom. | pmid:3242671 |
Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
Stewart AG and Dusting GJ | Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages. | 1988 | Br. J. Pharmacol. | pmid:2850058 |
Korth R et al. | Comparison of three paf-acether receptor antagonist ginkgolides. | 1988 | Eur. J. Pharmacol. | pmid:2850196 |
Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
Fu JM | [Effects of platelet activating factor on blood platelets]. | 1989 | Sheng Li Ke Xue Jin Zhan | pmid:2549618 |
Hwang SB | Competitive inhibition of tritium-labeled platelet-activating factor binding to rabbit platelet membranes by amiloride and amiloride analogs. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2549986 |
Schmidt HH et al. | Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4. | 1989 | FEBS Lett. | pmid:2537760 |
Stjernschantz J and Bito LZ | The ocular effects of eicosanoids and other autacoids: historic background and the need for a broader perspective. | 1989 | Prog. Clin. Biol. Res. | pmid:2571999 |
Valone FH et al. | Mechanisms for biphasic or persistent immunologic reactions induced by platelet-activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2685826 |
Taylor RR et al. | Plasma levels of the lyso-derivative of platelet-activating factor are related to age. | 1989 | Clin. Sci. | pmid:2924511 |
Battista PJ et al. | The effects of platelet-activating factor and platelet-derived compounds on bovine luteal cell progesterone production. | 1989 | Biol. Reprod. | pmid:2787672 |
Fisher RA et al. | Platelet-activating factor increases inositol phosphate production and cytosolic free Ca2+ concentrations in cultured rat Kupffer cells. | 1989 | FEBS Lett. | pmid:2787759 |
Ibbotson GC and Wallace JL | Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis. | 1989 | Prostaglandins | pmid:2727308 |
Mollard P et al. | Inhibitors of 1,2-diacylglycerol kinase potentiate the TRH-induced stimulation of Ca2+-activated K+ current. | 1989 | Eur. J. Pharmacol. | pmid:2541000 |
Kroegel C et al. | Stimulation of degranulation from human eosinophils by platelet-activating factor. | 1989 | J. Immunol. | pmid:2541198 |
Kemény L et al. | Pharmacological studies on dithranol-induced irritative dermatitis in mice. | 1989 | Arch. Dermatol. Res. | pmid:2529819 |
Ostermann G et al. | The contribution of individual lipoproteins to the degradation of platelet-activating factor in human serum. | 1989 | Haemostasis | pmid:2744632 |
Hofmann B et al. | Enhanced degradation of platelet-activating factor in serum from diabetic patients. | 1989 | Haemostasis | pmid:2744634 |
Keraly CL et al. | The role of extracellular Ca2+ and Na+ in paf-acether-induced human platelet activation. | 1989 | Biochem. Pharmacol. | pmid:2818633 |
Parnham MJ et al. | Antagonism of platelet activating factor-induced chemiluminescence in guinea-pig peritoneal macrophages in differing states of activation. | 1989 | Br. J. Pharmacol. | pmid:2819335 |
Beaumont DO et al. | Measuring platelet function with platelet shape change, an early event in aggregation. | 1989 | Thromb. Res. | pmid:2646752 |
Camussi G et al. | Platelet-activating factor in renal diseases. | 1989 | Am. J. Nephrol. | pmid:2646923 |
Morrison WJ et al. | Staurosporine potentiates platelet activating factor stimulated phospholipase C activity in rabbit platelets but does not block desensitization by platelet activating factor. | 1989 | Life Sci. | pmid:2761347 |
Pique JM et al. | Modulation of rat gastric blood flow during PAF challenge by opiate-sensitive afferent neurones. | 1989 | Br. J. Pharmacol. | pmid:2611505 |
Murphy CT and Westwick J | Characterisation of platelet-activating factor-induced diacylglycerol generation in rabbit platelets. | 1989 | Br. J. Pharmacol. | pmid:2611539 |
Joseph R and Welch KM | Granulocytes, platelet-activating factor, and myocardial injury. | 1989 | Circulation | pmid:2720936 |
Gerkens JF | Inhibition of vasoconstriction by platelet activating factor in the in situ blood perfused rat mesentery. | 1989 | Clin. Exp. Pharmacol. Physiol. | pmid:2721028 |
Tool AT et al. | Platelet-activating factor (PAF) acts as an intercellular messenger in the changes of cytosolic free Ca2+ in human neutrophils induced by opsonized particles. | 1989 | FEBS Lett. | pmid:2599108 |
Bussolino F et al. | Platelet-activating factor enhances complement-dependent phagocytosis of diamide-treated erythrocytes by human monocytes through activation of protein kinase C and phosphorylation of complement receptor type one (CR1). | 1989 | J. Biol. Chem. | pmid:2600088 |
Rosenthal MD and Franson RC | Oligomers of prostaglandin B1 inhibit arachidonic acid mobilization in human neutrophils and endothelial cells. | 1989 | Biochim. Biophys. Acta | pmid:2557075 |