Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Travers JB et al. | Identification and pharmacological characterization of platelet-activating factor and related 1-palmitoyl species in human inflammatory blistering diseases. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990675 |
| Wang MM et al. | In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. | 1999 | Biochim. Biophys. Acta | pmid:9989266 |
| Snyder F | The ether lipid trail: a historical perspective. | 1999 | Biochim. Biophys. Acta | pmid:9989259 |
| Syrbu SI et al. | Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils. | 1999 | J. Immunol. | pmid:9973512 |
| Hayani KC et al. | Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children. | 1999 | J. Infect. Dis. | pmid:9952364 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Piwinski JJ et al. | Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9934454 |
| Lee LW et al. | Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. | 1999 | Eur. J. Pharmacol. | pmid:9932729 |
| Ohshige A et al. | Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. | 1999 | Obstet Gynecol | pmid:9932551 |
| Bazan NG | The neuromessenger platelet-activating factor in plasticity and neurodegeneration. | 1998 | Prog. Brain Res. | pmid:9932449 |
| McCall MR et al. | Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility. | 1999 | Biochim. Biophys. Acta | pmid:9931415 |
| Onorato JM et al. | Immunohistochemical and ELISA assays for biomarkers of oxidative stress in aging and disease. | 1998 | Ann. N. Y. Acad. Sci. | pmid:9928437 |
| Berger A et al. | Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927381 |
| Toledano BJ et al. | Characterization of B lymphocytes rescued from apoptosis by platelet-activating factor. | 1999 | Cell. Immunol. | pmid:9918687 |
| Gedeborg R and Wiklund L | Experimental model of cardiovascular post-resuscitation syndrome--no effect of platelet activating factor antagonism. | 1998 Oct-Nov | Resuscitation | pmid:9918458 |
| Stafforini DM and Tjoelker LW | Human plasma platelet-activating factor acetylhydrolase. | 1999 | Methods Mol. Biol. | pmid:9918011 |
| Siddiqui RA et al. | Chemotactic migration triggers IL-8 generation in neutrophilic leukocytes. | 1999 | J. Immunol. | pmid:9916736 |
| Zhang Y et al. | RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. | 1999 | J. Biol. Chem. | pmid:9915820 |
| Qu XW et al. | The role of xanthine oxidase in platelet activating factor induced intestinal injury in the rat. | 1999 | Gut | pmid:9895379 |
| Tetta C et al. | The role of platelet-activating factor in the haemoincompatibility of haemodialytic treatments. | 1998 | Int J Artif Organs | pmid:9894743 |
| Yamaguchi S et al. | Effect of Y-24180, an antagonist at platelet-activating factor (PAF) receptors, on IgE-mediated cutaneous reactions in mice. | 1998 | Inflamm. Res. | pmid:9892046 |
| Akiba S et al. | Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9891858 |
| Longphre M et al. | Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF. | 1999 | J. Appl. Physiol. | pmid:9887149 |
| Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Chang FR et al. | Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea. | 1998 | Phytochemistry | pmid:9883592 |
| Nakano T et al. | Roxythromycin reinforces epithelial defence function in rabbit trachea. | 1998 | Acta Otolaryngol Suppl | pmid:9879427 |
| Todoroki H et al. | Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. | 1998 | J. Surg. Res. | pmid:9878306 |
| Kawasaki Y et al. | Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens. | 1998 | FEBS Lett. | pmid:9877177 |
| Dhainaut JF et al. | Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group. | 1998 | Crit. Care Med. | pmid:9875905 |
| Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
| Huh H et al. | PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra. | 1998 | Arch. Pharm. Res. | pmid:9875472 |
| Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
| Chen JZ et al. | A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871752 |
| Powell WS et al. | 5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:9870930 |
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| Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
| Kaminskaia GO et al. | [Oxidative metabolic changes, antioxidantion, and platelet activation rat phagocytes during development of experimental specific tuberculous changes]. | 1998 | Probl Tuberk | pmid:9866402 |
| Pesce L et al. | Effect of Fenoterol on PAF-induced lung edema in isolated and perfused rabbit lungs. | 1998 | Respir Physiol | pmid:9865589 |
| Hammer C et al. | Xenogeneic rejection mechanisms shown by intravital microscopy. | 1998 | Transplant. Proc. | pmid:9865335 |
| Jeanneton O et al. | Correlation of desensitisation of platelet activating factor (PAF) receptors with intensity of inflammation and intestinal PAF content during experimental ileitis in guinea pig. | 1998 | Gut | pmid:9863481 |
| Nagai H et al. | Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice. | 1999 | J. Pharmacol. Exp. Ther. | pmid:9862751 |
| Egesten A and Malm J | Eosinophil leukocyte degranulation in response to serum-opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C. | 1998 | Allergy | pmid:9860239 |
| Chihara J et al. | Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). | 1998 | Ann. Allergy Asthma Immunol. | pmid:9860039 |
| Sharif NA et al. | Human corneal epithelial cell functional responses to inflammatory agents and their antagonists. | 1998 | Invest. Ophthalmol. Vis. Sci. | pmid:9856766 |
| Stamatiou P et al. | 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. | 1998 | J. Clin. Invest. | pmid:9854052 |
| Gardner JP and Zhang L | Glucocorticoid modulation of Ca2+ homeostasis in human B lymphoblasts. | 1999 | J. Physiol. (Lond.) | pmid:9852321 |
| Reiner O and Sapir T | Abnormal cortical development; towards elucidation of the LIS1 gene product function (review). | 1998 | Int. J. Mol. Med. | pmid:9852306 |
| Reverdiau-Moalic P et al. | Human allogeneic lymphocytes trigger endothelial cell tissue factor expression by a tumor necrosis factor-dependent pathway. | 1998 | J. Lab. Clin. Med. | pmid:9851744 |
| Xiao YQ et al. | Pharmacological analysis of protein kinases responsible for chemotaxis of rat peritoneal neutrophils. | 1998 | Eur. J. Pharmacol. | pmid:9851586 |
| Steil AA et al. | Modulation by lipid mediators of immune complex-induced lung inflammation in mice. | 1998 | Eur. J. Pharmacol. | pmid:9851546 |
| Swain SD et al. | Platelet-activating factor induces a concentration-dependent spectrum of functional responses in bovine neutrophils. | 1998 | J. Leukoc. Biol. | pmid:9850166 |
| Jean WC et al. | Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. | 1998 | Neurosurgery | pmid:9848853 |
| Masubuchi T et al. | Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity. | 1998 | Am. J. Pathol. | pmid:9846980 |
| Koyama S et al. | Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. | 1998 | Am. J. Pathol. | pmid:9846978 |
| Kimura S et al. | Suppressive effects of antihistaminic and/or anti-PAF agents on passive anaphylactic shock in mice sensitized with allogeneic monoclonal IgE and IgG1 antibodies and hyperimmune serum. | 1998 | Immunol. Invest. | pmid:9845423 |
| Witko-Sarsat V et al. | Priming of blood neutrophils in children with cystic fibrosis: correlation between functional and phenotypic expression of opsonin receptors before and after platelet-activating factor priming. | 1999 | J. Infect. Dis. | pmid:9841834 |
| Fukunaga K et al. | Successful liver transplantation from non-heart-beating donors by blockade of endothelin and PAE. | 1998 | Transplant. Proc. | pmid:9838664 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Ottlakán A | Role of platelet-activating factor in glucose uptake and utilization of different tissues. | 1998 | Eur Surg Res | pmid:9838231 |
| Travers J et al. | Antiinflammatory activity of the platelet-activating factor receptor antagonist A-85783. | 1998 | Arch. Dermatol. Res. | pmid:9836508 |
| Dupuis F et al. | Effect of platelet-activating factor on the growth of human erythroid and myeloid CD34+ progenitors. | 1998 | Mediators Inflamm. | pmid:9836496 |
| Stack WA et al. | Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis. | 1998 | Gastroenterology | pmid:9834260 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Ohashi H et al. | Sulochrin inhibits eosinophil activation and chemotaxis. | 1998 | Inflamm. Res. | pmid:9831326 |
| Itabe H | Oxidized phospholipids as a new landmark in atherosclerosis. | 1998 Jul-Aug | Prog. Lipid Res. | pmid:9829125 |
| Smalley DM et al. | Platelet activating factor (PAF) increases leukocyte adhesion but does not alter vessel diameter in the rat mesenteric microcirculation. | 1998 | Microvasc. Res. | pmid:9828165 |
| Kilgore KS et al. | Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: the roles of P-selectin and platelet activating factor. | 1998 | Inflammation | pmid:9824773 |
| Pulliam L et al. | Differential modulation of cell death proteins in human brain cells by tumor necrosis factor alpha and platelet activating factor. | 1998 | J. Neurosci. Res. | pmid:9822163 |
| Akisü M et al. | Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia? | 1998 | Acta Paediatr Jpn | pmid:9821700 |
| Takafuji S et al. | Release of granule proteins from human eosinophils stimulated with mast-cell mediators. | 1998 | Allergy | pmid:9821474 |
| Malpuech-Brugère C et al. | Exacerbated immune stress response during experimental magnesium deficiency results from abnormal cell calcium homeostasis. | 1998 | Life Sci. | pmid:9820125 |
| Siafaka-Kapadai A et al. | Effects of suramin on human platelet aggregation and Ca2+ mobilization induced by thrombin and other agonists. | 1998 | Life Sci. | pmid:9820121 |
| Kwiterovich PO | The antiatherogenic role of high-density lipoprotein cholesterol. | 1998 | Am. J. Cardiol. | pmid:9819099 |
| Nakos G et al. | Bronchoalveolar lavage alterations in pulmonary embolism. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9817700 |
| Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
| Denizot Y et al. | Effects of lipid mediators on the synthesis of leukaemia inhibitory factor and interleukin 6 by human bone marrow stromal cells. | 1998 | Cytokine | pmid:9811531 |
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| Aida Y et al. | Effects of chroman derivatives on platelet aggregation induced by some aggregating agents in rabbits. | 1998 | Clin. Exp. Pharmacol. Physiol. | pmid:9807668 |
| Izzo AA et al. | Recent findings on the mode of action of laxatives: the role of platelet activating factor and nitric oxide. | 1998 | Trends Pharmacol. Sci. | pmid:9803830 |
| Choi IH et al. | Immunoglobulin E-dependent active fatal anaphylaxis in mast cell-deficient mice. | 1998 | J. Exp. Med. | pmid:9802970 |
| Templeton AG et al. | Effects of S-salbutamol on human isolated bronchus. | 1998 | Pulm Pharmacol Ther | pmid:9802957 |
| Hofbauer B et al. | Effect of recombinant platelet-activating factor acetylhydrolase on two models of experimental acute pancreatitis. | 1998 | Gastroenterology | pmid:9797380 |
| Pestonjamasp VK and Burstein SH | Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. | 1998 | Biochim. Biophys. Acta | pmid:9795237 |
| Ohno Y et al. | Effects of platelet activating factor on the tubotympanic mucosa and inner ear in the guinea pig. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9794619 |
| Kaneshiro ES et al. | Characterizations of Pneumocystis carinii and rat lung lipids: glyceryl ethers and fatty alcohols. | 1998 | J. Lipid Res. | pmid:9788237 |
| O'Neill C | Role of autocrine mediators in the regulation of embryo viability: lessons from animal models. | 1998 | J. Assist. Reprod. Genet. | pmid:9785192 |
| Momose T et al. | Effects of intracellular cyclic AMP modulators on human eosinophil survival, degranulation and CD11b expression. | 1998 | Int. Arch. Allergy Immunol. | pmid:9784658 |
| Akisü M et al. | Platelet-activating factor is an important mediator in hypoxic ischemic brain injury in the newborn rat. Flunarizine and Ginkgo biloba extract reduce PAF concentration in the brain. | 1998 | Biol. Neonate | pmid:9784635 |
| Carlson SA and Jones BD | Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins. | 1998 | Infect. Immun. | pmid:9784535 |
| SariahmetoÄŸlu M et al. | Effects of WEB 2086 on the protective role of preconditioning against arrhythmias in rats. | 1998 | Pharmacol. Res. | pmid:9782066 |
| Akisü M et al. | The effect of L-carnitine on platelet activating factor concentration in the immature rat model of hypoxic-ischemic brain injury. | 1998 | Acta Med. Okayama | pmid:9781268 |
| Serebruany VL et al. | Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction. | 1998 | Cardiology | pmid:9778550 |
| Shah BH et al. | The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. | 1998 | Biochem. Pharmacol. | pmid:9776305 |
| Suzuki T et al. | 2-(3-Pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure-activity relationships and active configuration of 2-(3-pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists. | 1998 | Chem. Pharm. Bull. | pmid:9775441 |
| Teather LA et al. | Effects of posttraining intrahippocampal injections of platelet-activating factor and PAF antagonists on memory. | 1998 | Neurobiol Learn Mem | pmid:9774526 |
| Perez S et al. | Inhibition by the anti-mitotic drug doxorubicin of platelet-activating-factor-induced late eosinophil accumulation in rats. | 1998 | Eur. J. Pharmacol. | pmid:9774255 |
| Abu-Zidan FM | Hope or hype for lexipafant? | 1998 | Nature | pmid:9774090 |
| Le Blanc K et al. | Impaired platelet binding of fibrinogen due to a lower number of GPIIB/IIIA receptors in polycythemia vera. | 1998 | Thromb. Res. | pmid:9772010 |