Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Rhee CK et al. | Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs. | 1999 | Ann. Otol. Rhinol. Laryngol. | pmid:10335705 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |
Ganbo T et al. | Effects of platelet activating factor on mucociliary clearance of the eustachian tube. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8659935 |
Lin J et al. | Effect of lipoxygenase inhibition on mucous glycoprotein secretion from chinchilla middle ear epithelial cells in vitro. | 1996 | Ann. Otol. Rhinol. Laryngol. | pmid:8916869 |
Rhee CK et al. | Experimental otitis media with effusion induced by platelet activating factor. | 1993 | Ann. Otol. Rhinol. Laryngol. | pmid:8352483 |
Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
Price JE et al. | In vitro platelet aggregability studies: lack of evidence for platelet hyperactivity in systemic sclerosis. | 1991 | Ann. Rheum. Dis. | pmid:1888199 |
Hilliquin P et al. | Presence of paf-acether in rheumatic diseases. | 1992 | Ann. Rheum. Dis. | pmid:1540032 |
Herrero-Beaumont G and Egido J | PAF, a potent proinflammatory mediator, looking for its role in the pathogenesis of joint damage. | 1997 | Ann. Rheum. Dis. | pmid:9165991 |
Hilliquin P et al. | Treatment of carrageenan induced arthritis by the platelet activating factor antagonist BN 50730. | 1995 | Ann. Rheum. Dis. | pmid:7702404 |
Eggleton P et al. | Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. | 1995 | Ann. Rheum. Dis. | pmid:7492242 |
Kaminski DL et al. | The role of prostanoids in the production of acute acalculous cholecystitis by platelet-activating factor. | 1990 | Ann. Surg. | pmid:2171443 |
Fletcher JR et al. | Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. | 1990 | Ann. Surg. | pmid:2178565 |
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Unno N et al. | Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. | 2002 | Ann. Surg. | pmid:11807372 |
Nathan N and Denizot Y | Platelet-activating factor antagonist and cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7677525 |
Zehr KJ et al. | Platelet activating factor inhibition reduces lung injury after cardiopulmonary bypass. | 1995 | Ann. Thorac. Surg. | pmid:7847945 |
Taggart DP | Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. | 2001 | Ann. Thorac. Surg. | pmid:11216754 |
Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
Corcoran PC et al. | Reduction of conjugated dienes in lung transplantation: effect of BN 52021. | 1993 | Ann. Thorac. Surg. | pmid:8267425 |
Qayumi AK et al. | Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation. | 1991 | Ann. Thorac. Surg. | pmid:1929620 |
Nathan N and Denizot Y | Tumor necrosis factor and platelet-activating factor during cardiopulmonary bypass. | 1993 | Ann. Thorac. Surg. | pmid:8494455 |
Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
Larsen GL and Henson PM | Mediators of inflammation. | 1983 | Annu. Rev. Immunol. | pmid:6399978 |
Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
Bach MK | Mediators of anaphylaxis and inflammation. | 1982 | Annu. Rev. Microbiol. | pmid:6128957 |
Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
Feuerstein G and Hallenbeck JM | Prostaglandins, leukotrienes, and platelet-activating factor in shock. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3034139 |
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Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
Zimmermann A and Keller H | Shape changes and chemokinesis of Walker carcinosarcoma cells: effects of protein kinase inhibitors (HA-1004, polymyxin B, sangivamycin and tamoxifen) and an inhibitor of diacylglycerol kinase (R 59022). | 1993 Mar-Apr | Anticancer Res. | pmid:8390801 |
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Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
Torley LW et al. | Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. | 1992 | Antimicrob. Agents Chemother. | pmid:1416889 |
Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
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Cao YZ et al. | Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. | 2001 | Antioxid. Redox Signal. | pmid:11813988 |
Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
Subissi A et al. | Octylonium bromide, an antagonist of platelet-activating factor. | 1989 Nov-Dec | Arch Int Pharmacodyn Ther | pmid:2636821 |
Yamada T et al. | Pharmacological properties of YM264, a potent and orally active antagonist of platelet-activating factor. | 1990 Nov-Dec | Arch Int Pharmacodyn Ther | pmid:2099131 |
Damas J et al. | Inhibition by WEB 2086, a PAG-acether antagonist of oedema and peritonitis induced by zymosan in rats. | 1990 Jul-Aug | Arch Int Pharmacodyn Ther | pmid:2076045 |
Damas J and Prunescu P | Presence of immunoreactive platelet-activating factor in peritoneal exudate induced by zymosan in rats. | 1993 Mar-Apr | Arch Int Pharmacodyn Ther | pmid:8215712 |
Hemmendinger S et al. | [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. | 1985 | Arch Mal Coeur Vaiss | pmid:3938941 |
Jambou D et al. | [Mediators of the vascular endothelium as markers of myocardial ischemia and reperfusion]. | 1993 | Arch Mal Coeur Vaiss | pmid:8304814 |
Gateau O | [Role of PAF-acether (platelet activating factor) in cardio-vascular pathology]. | 1987 | Arch Mal Coeur Vaiss | pmid:3117010 |
Partrick DA et al. | Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. | 2000 | Arch Surg | pmid:10668885 |
Kelly GL and Eiseman B | Development of a new vascular prosthetic: lessons learned. | 1982 | Arch Surg | pmid:7125901 |
Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
Emil S et al. | Inhaled nitric oxide prevents experimental platelet activating factor-induced shock. | 1996 | Arch Surg | pmid:8712910 |
Biffl WL et al. | Interleukin-6 potentiates neutrophil priming with platelet-activating factor. | 1994 | Arch Surg | pmid:7979944 |
Lo CJ et al. | Endotoxin-induced macrophage gene expression depends on platelet-activating factor. | 1997 | Arch Surg | pmid:9403541 |
Fletcher JR | Eicosanoids. Critical agents in the physiological process and cellular injury. | 1993 | Arch Surg | pmid:8239981 |
Thompson WA et al. | The metabolic effects of platelet-activating factor antagonism in endotoxemic man. | 1994 | Arch Surg | pmid:8279943 |
Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
Jones RE | Synthesis of ether lipids and phosphatidylethanolamine by ejaculated human spermatozoa. | 1997 May-Jun | Arch. Androl. | pmid:9140614 |
Ohtsuka T et al. | Synergism between platelet-activating factor and diacylglycerol in the induction of superoxide anion production in guinea pig polymorphonuclear leukocytes. | 1990 | Arch. Biochem. Biophys. | pmid:2159756 |
Shukla SD and Hanahan DJ | An early transient decrease in phosphatidylinositol 4,5-bisphosphate upon stimulation of rabbit platelets with acetylglycerylether phosphorylcholine (platelet activating factor). | 1983 | Arch. Biochem. Biophys. | pmid:6320731 |
Lee T et al. | Differential regulation of three catalytic activities of platelet-activating factor (PAF)-dependent transacetylase. | 2001 | Arch. Biochem. Biophys. | pmid:11368182 |
Furukawa M et al. | Metabolic fate of platelet-activating factor in the rat enterocyte: the role of a specific lysophospholipase D. | 1995 | Arch. Biochem. Biophys. | pmid:7771795 |
Lekka M et al. | Isolation of a phospholipid inhibitor of platelet activating factor-induced activity from perfused rat liver: identification as phosphatidylglycerol. | 1993 | Arch. Biochem. Biophys. | pmid:8489242 |
Shukla SD | Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. | 1985 | Arch. Biochem. Biophys. | pmid:3875314 |
Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
Kimoto M et al. | Dual effects of oleic acid on Ca2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1384432 |
Kajiyama Y et al. | Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2505676 |
Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
Zhou W and Olson MS | A mechanism for phorbol ester-mediated regulation of the PAF receptor in human neutrophils. | 1994 | Arch. Biochem. Biophys. | pmid:8053680 |
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Zhou W et al. | Impaired surface expression of PAF receptors on human neutrophils is dependent upon cell activation. | 1994 | Arch. Biochem. Biophys. | pmid:8109973 |
Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
Tokumura A et al. | Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin. | 1986 | Arch. Biochem. Biophys. | pmid:3013094 |
Satouchi K et al. | Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor. | 1984 | Arch. Biochem. Biophys. | pmid:6486825 |
Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
Svetlov SI et al. | Interaction of platelet-activating factor with rat hepatocytes: uptake, translocation, metabolism, and effects on PAF-acetylhydrolase secretion and protein tyrosine phosphorylation. | 1996 | Arch. Biochem. Biophys. | pmid:8615681 |
Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Enhancement of chlorophyll a fluorescence yield, low-temperature F685/F730 fluorescence emission ratio, and electron transport rate by ether phospholipids (platelet activating factor and analogs) in isolated chloroplasts. | 1989 | Arch. Biochem. Biophys. | pmid:2817899 |
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Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. | 1985 | Arch. Biochem. Biophys. | pmid:4037794 |
Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
Nunez D et al. | Inhibition of [3H]platelet activating factor (PAF) binding by Zn2+: a possible explanation for its specific PAF antiaggregating effects in human platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2502069 |
Lee TC et al. | Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway. | 1983 | Arch. Biochem. Biophys. | pmid:6407399 |
Homma H and Hanahan DJ | Attenuation of platelet activating factor (PAF)-induced stimulation of rabbit platelet GTPase by phorbol ester, dibutyryl cAMP, and desensitization: concomitant effects on PAF receptor binding characteristics. | 1988 | Arch. Biochem. Biophys. | pmid:2833174 |
Ihara Y et al. | Hormonal regulation of platelet-activating factor-acetyltransferase activity in rat tissues. | 1993 | Arch. Biochem. Biophys. | pmid:8346925 |
Sanwick JM et al. | Human spermatozoa produce C16-platelet-activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1575513 |
Hwang SB | Specific receptor sites for platelet activating factor on rat liver plasma membranes. | 1987 | Arch. Biochem. Biophys. | pmid:2821908 |
Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
Pieroni G and Hanahan DJ | Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets. | 1983 | Arch. Biochem. Biophys. | pmid:6870274 |
Sugiura T et al. | Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor. | 1994 | Arch. Biochem. Biophys. | pmid:8203898 |