Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Heller A et al. | Lipid mediators in inflammatory disorders. | 1998 | Drugs | pmid:9561339 |
Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
Cherniad'eva IF et al. | [Characteristics of development of oxidative stress in blood plasma of patients with familial hypercholesterolemia]. | 1998 | Biull Eksp Biol Med | pmid:9559141 |
Partrick DA et al. | Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release. | 1998 | J Trauma | pmid:9555828 |
Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |
Bonsignore L et al. | One-step synthesis and pharmacological activity of new (N-substituted)amino-spiroalkan-dione derivatives. | 1997 | Farmaco | pmid:9550091 |
Ishii I et al. | Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. | 1998 | J. Biol. Chem. | pmid:9545329 |
Yamada T et al. | Effects of inhaled nitric oxide on platelet-activating factor-induced pulmonary hypertension in dogs. | 1998 | Acta Anaesthesiol Scand | pmid:9542566 |
Michibayashi T | Different types of vasocontractile responses to noradrenaline in the presence of platelets with platelet activating factor. | 1997 | J Smooth Muscle Res | pmid:9533823 |
Ostrovsky L et al. | A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. | 1998 | Blood | pmid:9531616 |
Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
Mabilat-Pragnon C et al. | Urokinase localization and activity in isolated eosinophils. | 1997 | Thromb. Res. | pmid:9526961 |
Kulikov VI and Muzya GI | The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions. | 1998 | Biochemistry Mosc. | pmid:9526094 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
Lopes-Martins RA et al. | The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release. | 1997 | J Lipid Mediat Cell Signal | pmid:9524924 |
Yoshikawa T et al. | alpha-Tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells. | 1998 | Biofactors | pmid:9523024 |
Evangelista S et al. | Antihistaminic and antiallergic properties of dextro-mequitamium iodide in upper and lower guinea pig airways: comparison with azelastine. | 1998 | Gen. Pharmacol. | pmid:9522168 |