Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Agranulocytosis D000380 7 associated lipids
Albuminuria D000419 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Anthrax D000881 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthus Reaction D001183 8 associated lipids
Ascites D001201 25 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Asthma D001249 52 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Brain Diseases D001927 27 associated lipids
Brain Edema D001929 20 associated lipids
Brain Injuries D001930 4 associated lipids
Bronchial Diseases D001982 3 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchiectasis D001987 7 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Burns D002056 34 associated lipids
Burns, Inhalation D002059 4 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Death, Sudden D003645 12 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Dyslexia D004410 3 associated lipids
Ear Diseases D004427 7 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Epilepsy D004827 35 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Fever D005334 35 associated lipids
Fibrosis D005355 23 associated lipids
Gastritis D005756 27 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Glioma D005910 112 associated lipids
Gliosis D005911 6 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Heart Arrest D006323 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Injuries D006335 6 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Hemolysis D006461 131 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Diez-Fraile A et al. Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. 2004 Am. J. Vet. Res. pmid:15524330
McClenahan DJ et al. Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. 2000 Am. J. Vet. Res. pmid:10714514
Kingston JK et al. Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. 2002 Am. J. Vet. Res. pmid:11939312
Menzies-Gow NJ et al. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. 2008 Am. J. Vet. Res. pmid:18241016
Wilson DV et al. Histologic and ultrastructural changes after large-colon torsion, with and without use of a specific platelet-activating factor antagonist (WEB 2086), in ponies. 1994 Am. J. Vet. Res. pmid:8067617
Dodam JR et al. Effect of pertussis toxin and B-oligomer on platelet-activating factor-induced generation of inositol phosphates in porcine alveolar macrophages. 1996 Am. J. Vet. Res. pmid:8712527
McClenahan DJ et al. In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. 2002 Am. J. Vet. Res. pmid:11911574
Watanabe M et al. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. 2016 Am. J. Vet. Res. pmid:27580108
Symposium on The Clinical Importance of Leukotrienes and Platelet-activating Factor in Allergic Respiratory Diseases. November 14, 1990, San Francisco, California. 1991 Am. Rev. Respir. Dis. pmid:1673326
Christman BW et al. Effect of platelet-activating factor receptor antagonism on endotoxin-induced lung dysfunction in awake sheep. 1990 Am. Rev. Respir. Dis. pmid:2174655
Lohman IC and Halonen M The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. 1993 Am. Rev. Respir. Dis. pmid:8484635
Kohrogi H et al. Inhibition of neutral endopeptidase potentiates bronchial contraction induced by immune response in guinea pigs in vitro. 1991 Am. Rev. Respir. Dis. pmid:1892304
Thivierge M and Rola-Pleszczynski M Enhancement of pulmonary natural killer cell activity by platelet activating factor. Mechanisms of activation involving Ca2+, protein kinase C, and lipooxygenase products. 1991 Am. Rev. Respir. Dis. pmid:1650153
Kaye MG and Smith LJ Effects of inhaled leukotriene D4 and platelet-activating factor on airway reactivity in normal subjects. 1990 Am. Rev. Respir. Dis. pmid:2183659
Hamasaki Y et al. Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. 1984 Am. Rev. Respir. Dis. pmid:6547031
Halonen M et al. Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. 1985 Am. Rev. Respir. Dis. pmid:3881060
Boschetto P et al. Corticosteroid inhibition of airway microvascular leakage. 1991 Am. Rev. Respir. Dis. pmid:2001074
Burhop KE et al. Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. 1986 Am. Rev. Respir. Dis. pmid:3752711
Daniel EE and O'Byrne P Effect of inflammatory mediators on airway nerves and muscle. 1991 Am. Rev. Respir. Dis. pmid:2003686
Meade CJ and Heuer H PAF antagonism as an approach to the treatment of airway hyperreactivity. 1991 Am. Rev. Respir. Dis. pmid:2003696
Rylander R and Beijer L Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3541718
Henderson WR Eicosanoids and platelet-activating factor in allergic respiratory diseases. 1991 Am. Rev. Respir. Dis. pmid:1902069
Kazimierczak W et al. Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. 1984 Am. Rev. Respir. Dis. pmid:6201094
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Christman BW et al. Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. 1987 Am. Rev. Respir. Dis. pmid:3592402
Benveniste J A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? 1987 Am. Rev. Respir. Dis. pmid:3592414
Halonen M et al. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. 1981 Am. Rev. Respir. Dis. pmid:7294504
Lohman I and Halonen M Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. 1990 Am. Rev. Respir. Dis. pmid:2382903
Stenmark KR et al. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. 1987 Am. Rev. Respir. Dis. pmid:3631747
Caplan MS et al. Circulating plasma platelet activating factor in persistent pulmonary hypertension of the newborn. 1990 Am. Rev. Respir. Dis. pmid:2252241
Lien DC et al. Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea. 1992 Am. Rev. Respir. Dis. pmid:1546852
Barer GR et al. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. 1989 Am. Rev. Respir. Dis. pmid:2817616
Nakajima H et al. CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. 1992 Am. Rev. Respir. Dis. pmid:1362635
Brigham KL Conference summary: lipid mediators in the pulmonary circulation. 1987 Am. Rev. Respir. Dis. pmid:2820285
Smith LJ et al. Mechanism of platelet activating factor-induced bronchoconstriction in humans. 1988 Am. Rev. Respir. Dis. pmid:3195800
Pretolani M et al. Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. 1988 Am. Rev. Respir. Dis. pmid:3202509
Henson PM et al. NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. 1992 Am. Rev. Respir. Dis. pmid:1312316
Schellenberg RR Airway responses to platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3310779
Pretolani M et al. Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. 1990 Am. Rev. Respir. Dis. pmid:2160213
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Horvath CJ et al. Role of platelet-activating factor in mediating tumor necrosis factor alpha-induced pulmonary vasoconstriction and plasma-lymph protein transport. 1991 Am. Rev. Respir. Dis. pmid:1741548
Arnoux B et al. Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. 1988 Am. Rev. Respir. Dis. pmid:3354991
Zimmerman GA et al. Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. 1987 Am. Rev. Respir. Dis. pmid:3300444
Murphy RC and Clay KL Measurement of platelet-activating factor by physicochemical technique s. 1987 Am. Rev. Respir. Dis. pmid:3300445
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Scappaticci E et al. Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. 1992 Am. Rev. Respir. Dis. pmid:1336939
Boschetto P et al. Effect of antiasthma drugs on microvascular leakage in guinea pig airways. 1989 Am. Rev. Respir. Dis. pmid:2563319
Lansing MW et al. Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. 1991 Am. Rev. Respir. Dis. pmid:1741541
Lellouch-Tubiana A et al. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. 1988 Am. Rev. Respir. Dis. pmid:3281530
Gulbenkian AR et al. Anaphylactic challenge causes eosinophil accumulation in bronchoalveolar lavage fluid of guinea pigs. Modulation by betamethasone, phenidone, indomethacin, WEB 2086, and a novel antiallergy agent, SCH 37224. 1990 Am. Rev. Respir. Dis. pmid:2117872