Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Kawasaki T and Snyder F | Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. | 1988 | J. Biol. Chem. | pmid:3422635 |
Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
Guinot P et al. | Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. | 1988 | Lancet | pmid:2898694 |
Michel L et al. | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. | 1988 | J. Allergy Clin. Immunol. | pmid:2899102 |
Bourdillat B et al. | Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. | 1988 | Eur. J. Pharmacol. | pmid:2836213 |
Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
Yamada K et al. | Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. | 1988 | Biochem. Pharmacol. | pmid:3128296 |
Martins MA et al. | Intravenous injections of PAF-acether induce platelet aggregation in rats. | 1988 | Eur. J. Pharmacol. | pmid:3135199 |
Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
Fernandez-Gallardo S et al. | Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. | 1988 | Int. J. Immunopharmacol. | pmid:3139574 |
Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
Neuwirth R et al. | Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. | 1988 | J. Clin. Invest. | pmid:3166467 |
Rossi AG et al. | Stereospecific bioactions of 5-hydroxyeicosatetraenoate. | 1988 | FEBS Lett. | pmid:3191990 |
Nakamura T et al. | Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2898372 |
Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
Sun XM and Hsueh W | Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. | 1988 | J. Clin. Invest. | pmid:3366898 |
Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
Bratton DL et al. | Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. | 1988 | Biochim. Biophys. Acta | pmid:3370214 |
Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
Handley DA et al. | Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3183958 |
Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
Dorsch W et al. | Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. | 1988 | Biochem. Pharmacol. | pmid:2462422 |
Evans TW et al. | Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. | 1988 | Br. J. Pharmacol. | pmid:3401633 |
Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
Rylander R et al. | Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3403044 |
Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
Kumar R et al. | Production and effects of platelet-activating factor in the rat brain. | 1988 | Biochim. Biophys. Acta | pmid:3196741 |
Bette-Bobillo P and Bienvenue A | Platelet-activating-factor-induced serum-albumin release from rabbit platelets in the absence of calcium. | 1988 | Eur. J. Biochem. | pmid:3197724 |
Cueva JP and Hsueh W | Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. | 1988 | Gut | pmid:3197995 |
Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
Tkhostov EB et al. | [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:2969736 |
Leprevost C et al. | Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2971624 |
Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
Valone FH et al. | Enhanced human monocyte cytotoxicity by platelet-activating factor. | 1988 | Immunology | pmid:3169845 |
Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
Lagente V et al. | PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3171975 |
Danko G et al. | Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. | 1988 | Pharmacol Res Commun | pmid:3174804 |
Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
Imai T et al. | Pulmonary hypertension and edema induced by platelet-activating factor in isolated, perfused rat lungs are blocked by BN52021. | 1988 | J. Lab. Clin. Med. | pmid:3339274 |
Wichrowski B et al. | Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres. | 1988 | J. Med. Chem. | pmid:3339611 |
Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
Kelefiotis D et al. | Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. | 1988 | Life Sci. | pmid:3339951 |
Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
Arnout J et al. | Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man. | 1988 | Br J Clin Pharmacol | pmid:3289599 |
O'Donnell SR and Barnett CJ | pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. | 1988 | Br. J. Pharmacol. | pmid:3293683 |
Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
Kramer RM et al. | Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | 1988 | Biochim. Biophys. Acta | pmid:3355850 |
McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
Brass LF et al. | Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. | 1988 | J. Biol. Chem. | pmid:2833506 |
Blank ML et al. | Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. | 1988 | J. Biol. Chem. | pmid:2833508 |
Tatsumi N et al. | Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. | 1988 | Clin. Chim. Acta | pmid:3359655 |
Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
Worthen GS et al. | The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. | 1988 | J. Immunol. | pmid:2834441 |
Hwang SB et al. | Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841449 |
Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
Tahraoui L et al. | High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. | 1988 | Mol. Pharmacol. | pmid:2842653 |
Heuer H and Casals-Stenzel J | Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge. | 1988 | Agents Actions Suppl. | pmid:3262991 |
Garcia JG et al. | Effect of platelet activating factor on leukocyte-endothelial cell interactions. | 1988 | Thromb. Res. | pmid:2842887 |
Ontell SJ et al. | Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441. | 1988 | Gastroenterology | pmid:3263295 |
Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
Breviario F et al. | IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. | 1988 | J. Immunol. | pmid:3263425 |
Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
Bussolino F et al. | Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. | 1988 | J. Neurochem. | pmid:2846783 |
Birkle DL et al. | Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. | 1988 | J. Neurochem. | pmid:2846788 |
Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
Fradin A et al. | Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. | 1988 | Biochim. Biophys. Acta | pmid:2848583 |
Ghigo D et al. | Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. | 1988 | J. Biol. Chem. | pmid:2848827 |
Perico N et al. | Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. | 1988 | Lab. Invest. | pmid:3123798 |
Aratani H et al. | Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. | 1988 | Jpn. J. Pharmacol. | pmid:2848961 |
Fisher RA et al. | AGEPC: a potent calcium-dependent chemical mediator in the liver. | 1988 | Adv. Exp. Med. Biol. | pmid:3213685 |
Mickelson JK et al. | Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. | 1988 | J. Mol. Cell. Cardiol. | pmid:3216407 |
Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |
Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |
Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |