Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
Shukla SD | Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. | 1985 | Arch. Biochem. Biophys. | pmid:3875314 |
Wasserman SI | Mast cell mediators in the blood of patients with asthma. | 1985 | Chest | pmid:3880526 |
Halonen M et al. | Participation of platelets in the physiologic alterations of the AGEPC response and of IgE anaphylaxis in the rabbit. Effects of PGI2 inhibition of platelet function. | 1985 | Am. Rev. Respir. Dis. | pmid:3881060 |
Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
Juhan-Vague I et al. | Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. | 1985 | Thromb. Res. | pmid:3923649 |
Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
Hwang SB et al. | trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. | 1985 | J. Biol. Chem. | pmid:2999126 |
Camussi G et al. | The role of platelet-activating factor in experimental immune complex pathology. | 1985 | Int J Tissue React | pmid:2932406 |
Weber N and Mangold HK | Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. | 1985 | J. Lipid Res. | pmid:3891896 |
Hanahan DJ and Weintraub ST | Platelet-activating factor isolation, identification, and assay. | 1985 | Methods Biochem Anal | pmid:3894881 |
Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
Davis JW et al. | Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. | 1985 | Clin. Pharmacol. Ther. | pmid:3987176 |
Billah MM et al. | Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. | 1985 | J. Biol. Chem. | pmid:3922982 |
Shigenobu K et al. | Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. | 1985 | J. Pharmacobio-dyn. | pmid:4009403 |
Saeki S et al. | Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. | 1985 | Life Sci. | pmid:4010479 |
Nunn B et al. | Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers. | 1985 | Antimicrob. Agents Chemother. | pmid:4015075 |
Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
Archer CB et al. | Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? | 1985 | Br. J. Dermatol. | pmid:4015978 |
Morley J et al. | The role of circulating cells in skin reactions. | 1985 | Br. J. Dermatol. | pmid:4015983 |
Mushayakarara EC and Mantsch HH | Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. | 1985 | Can. J. Biochem. Cell Biol. | pmid:4075223 |
Zimmerman GA et al. | Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. | 1985 | J. Clin. Invest. | pmid:4077977 |
Young JM et al. | Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. | 1985 | Prostaglandins | pmid:4081060 |
Is there a case for PAF-acether antagonists? Institut Pasteur, Paris, 21 June 1985. Abstracts. | 1985 | Prostaglandins | pmid:4081064 | |
Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |
Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
Armstrong RA et al. | Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. | 1985 | Prostaglandins | pmid:2988022 |
Cox CP | Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). | 1985 | Comp Biochem Physiol A Comp Physiol | pmid:2864195 |
Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
Peach MJ et al. | Mechanisms of endothelium-dependent vascular smooth muscle relaxation. | 1985 | Biochem. Pharmacol. | pmid:2988558 |
Braquet M et al. | Leukocytic functions in burn-injured patients. | 1985 | Prostaglandins | pmid:2989978 |
Grandel KE et al. | Association of platelet-activating factor with primary acquired cold urticaria. | 1985 | N. Engl. J. Med. | pmid:2410790 |
Bussolino F et al. | Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. | 1985 | J. Immunol. | pmid:2411812 |
Johnson HM and Torres BA | Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2412225 |
Fjellner B and Hägermark O | Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. | 1985 | Acta Derm. Venereol. | pmid:2416164 |
Avdonin PV and Altukhova IP | [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. | 1985 | Biokhimiia | pmid:2416359 |
Lee TD et al. | Heterogeneity in mast cell populations. | 1985 | Clin Immunol Rev | pmid:2417770 |
Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
Bult H et al. | Complement derived factors and prostacyclin formation by rabbit isolated peritoneum and cultured mesothelial cells. | 1984 | Agents Actions Suppl. | pmid:6382974 |
Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |