Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
Furlan M et al. | Binding of colloidal gold granules, coated with bovine factor VIII, to human platelet membranes. | 1981 | Br. J. Haematol. | pmid:6786321 |
Benveniste J et al. | Platelet-activating factor (PAF-acether): molecular aspects of its release and pharmacological actions. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7030966 |
Brown JE and Thuy LP | The binding of bovine platelet aggregating factor to human platelets. | 1981 Apr 1-15 | Thromb. Res. | pmid:7292446 |
Camussi G et al. | Immune-induced leucopenia. A role for the aggregation of polymorphonuclear neutrophils in systemic lupus erythematosus (SLE). | 1981 Jul-Sep | Minerva Nefrol | pmid:7329598 |
Camussi G et al. | In vitro spasmogenic effect of platelet-activating factor on rabbit lung tissue. | 1981 Jul-Sep | Panminerva Med | pmid:7335369 |
De Clerck F and David JL | Pharmacological control of platelet and red blood cell function in the microcirculation. | 1981 Nov-Dec | J. Cardiovasc. Pharmacol. | pmid:6173539 |
Voelkel NF et al. | Nonimmunological production of leukotrienes induced by platelet-activating factor. | 1982 | Science | pmid:7123233 |
Kelly GL and Eiseman B | Development of a new vascular prosthetic: lessons learned. | 1982 | Arch Surg | pmid:7125901 |
Sugiura T et al. | Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. | 1982 | Biochim. Biophys. Acta | pmid:7126622 |
Vargaftig BB et al. | Non-steroidal anti-inflammatory drugs if combined with anti-histamine and anti-serotonin agents interfere with the bronchial and platelet effects of "platelet-activating factor" (PAF-acether). | 1982 | Eur. J. Pharmacol. | pmid:7128682 |
Namm DH et al. | Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine. | 1982 | Thromb. Res. | pmid:7071810 |
Keraly CL and Benveniste J | Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives. | 1982 | Br. J. Haematol. | pmid:7082588 |
Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
Czarneztki BM | Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release. | 1982 | Chem. Phys. Lipids | pmid:6814773 |
Chesney CM et al. | Effect of platelet-activating factor (PAF) on human platelets. | 1982 | Blood | pmid:7037068 |
Masugi F et al. | Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7041899 |
Lapetina EG | Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. | 1982 | J. Biol. Chem. | pmid:7045103 |
Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
Caillard CG et al. | Hypotensive activity of PAF-acether in rats. | 1982 | Agents Actions | pmid:6299079 |