Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Travers JB et al. Identification of sn-2 acetyl glycerophosphocholines in human keratinocytes. 1997 J Lipid Mediat Cell Signal pmid:9246603
Dupuis F et al. Effects of lipidic mediators on the growth of human myeloid and erythroid marrow progenitors. 1997 J Lipid Mediat Cell Signal pmid:9246601
Barnett CC et al. Beta-adrenergic stimulation down-regulates neutrophil priming for superoxide generation, but not elastase release. 1997 J. Surg. Res. pmid:9245567
Nakajima K et al. Activated mast cells release extracellular type platelet-activating factor acetylhydrolase that contributes to autocrine inactivation of platelet-activating factor. 1997 J. Biol. Chem. pmid:9242626
Henninger DD et al. Low-density lipoprotein receptor knockout mice exhibit exaggerated microvascular responses to inflammatory stimuli. 1997 Circ. Res. pmid:9242189
Davies MG and Hagen PO Systemic inflammatory response syndrome. 1997 Br J Surg pmid:9240130
Bunting M et al. Alpha toxin from Clostridium perfringens induces proinflammatory changes in endothelial cells. 1997 J. Clin. Invest. pmid:9239403
Sengoku K et al. Involvement of protein kinases in platelet activating factor-induced acrosome reaction of human spermatozoa. 1996 Mol. Hum. Reprod. pmid:9238710
Roussev RG et al. Embryonic origin of preimplantation factor (PIF): biological activity and partial characterization. 1996 Mol. Hum. Reprod. pmid:9237230
Filep JG et al. Glucocorticoid receptor regulates expression of L-selectin and CD11/CD18 on human neutrophils. 1997 Circulation pmid:9236448
Wang X and Evans RD Effect of endotoxin and platelet-activating factor on lipid oxidation in the rat heart. 1997 J. Mol. Cell. Cardiol. pmid:9236145
Pearson JM et al. Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration. 1997 Toxicology pmid:9231696
Triggiani M et al. Characterization of platelet-activating factor acetylhydrolase in human bronchoalveolar lavage. 1997 Am. J. Respir. Crit. Care Med. pmid:9230731
Díaz O et al. Inhibition of PAF-induced gas exchange defects by beta-adrenergic agonists in mild asthma is not due to bronchodilation. 1997 Am. J. Respir. Crit. Care Med. pmid:9230720
Evans DJ et al. Effects of a potent platelet-activating factor antagonist, SR27417A, on allergen-induced asthmatic responses. 1997 Am. J. Respir. Crit. Care Med. pmid:9230719
Rhee CK et al. Effects of platelet activating factor on vascular permeability of the middle ear mucosa. 1997 Ann. Otol. Rhinol. Laryngol. pmid:9228864
Ammit AJ and O'Neill C Studies of the nature of the binding by albumin of platelet-activating factor released from cells. 1997 J. Biol. Chem. pmid:9228051
Sirois MG and Edelman ER VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. 1997 Am. J. Physiol. pmid:9227554
Stahl GL et al. Eicosanoid production from porcine neutrophils and platelets: differential production with various agonists. 1997 Am. J. Physiol. pmid:9227410
Denault S et al. Transcriptional activation of the interleukin-8 gene by platelet-activating factor in human peripheral blood monocytes. 1997 Immunology pmid:9227331
Dupuis F et al. Production and metabolism of platelet-activating factor by human bone marrow cells. 1997 Res. Immunol. pmid:9226766
Serra MF et al. Anti-allergic properties of the natural PAF antagonist yangambin. 1997 Planta Med. pmid:9225600
Lopes AH et al. Effect of platelet-activating factor on the process of cellular differentiation of Herpetomonas muscarum muscarum. 1997 Jul-Aug J. Eukaryot. Microbiol. pmid:9225446
Korotaeva AA et al. Effect of lysophosphatidylcholine on the structure and function of low density lipoproteins. 1997 Membr Cell Biol pmid:9225256
Schwartz JD et al. Lexipafant inhibits platelet activating factor enhanced neutrophil functions. 1997 J. Surg. Res. pmid:9224389
Winkler JD et al. Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes. 1997 Biochim. Biophys. Acta pmid:9219900
Svetlov SI et al. Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. 1997 Biochim. Biophys. Acta pmid:9219895
Balestrieri ML et al. The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells. 1997 J. Biol. Chem. pmid:9211886
Hoffman BF et al. Electrophysiologic effects of interactions between activated canine neutrophils and cardiac myocytes. 1997 J. Cardiovasc. Electrophysiol. pmid:9209969
Bellone G et al. Bone marrow stroma-derived prolactin is involved in basal and platelet-activating factor-stimulated in vitro erythropoiesis. 1997 Blood pmid:9207433
Zhang S et al. [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. 1996 Zhonghua Fu Chan Ke Za Zhi pmid:9206185
Liu B et al. Effects of MTX and BN52021 on PAF-induced chemotaxis of PMNs and intraepidermal accumulation of inflammatory cells in guinea pigs. 1996 Chin. Med. J. pmid:9206081
Lin J et al. Dexamethasone inhibits mucous glycoprotein secretion via a phospholipase A2-dependent mechanism in cultured chinchilla middle ear epithelial cells. 1997 Acta Otolaryngol. pmid:9199527
Rocha MF et al. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes. 1997 Infect. Immun. pmid:9199444
Rodriguez-Roisin R Acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities. 1997 Eur. Respir. J. pmid:9192945
Sharma R et al. Direct effects of platelet-activating factor on glomerular capillary permeability. 1997 Kidney Blood Press. Res. pmid:9192907
Teixeira MM et al. Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo. 1997 Blood pmid:9192781
Hinterleitner TA et al. Platelet-activating factor contributes to immune cell and oxidant-mediated intestinal secretion. 1997 J. Pharmacol. Exp. Ther. pmid:9190862
Chen J and Giri SN Differences in platelet-activating factor receptor mediated Ca++ response between hamster and guinea pig alveolar macrophages. 1997 J. Pharmacol. Exp. Ther. pmid:9190835
van der Weiden RM and Wouters JM Infertility may sometimes be associated with non-steroidal anti-inflammatory drug consumption. 1997 Br. J. Rheumatol. pmid:9189067
Lacasse C et al. Platelet-activating factor stimulates interleukin-6 production by human endothelial cells and synergizes with tumor necrosis factor for enhanced production of granulocyte-macrophage colony stimulating factor. 1997 Inflammation pmid:9187959
Okubo Y et al. Inhibitory effects of theophylline and procaterol on eosinophil function. 1997 Intern. Med. pmid:9187566
Mathiak G et al. Platelet-activating factor (PAF) in experimental and clinical sepsis. 1997 Shock pmid:9185238
Bazan HE and Tao Y PAF antagonists as possible inhibitors of corneal epithelial defects and ulceration. 1997 J Ocul Pharmacol Ther pmid:9185044
Ephgrave K et al. The role of platelet-activating factor in conscious, normotensive endotoxemia. 1997 J. Surg. Res. pmid:9184676
Salcedo R et al. Endogenous fibronectin of blood polymorphonuclear leukocytes: stimulus-induced secretion and proteolysis by cell surface-bound elastase. 1997 Exp. Cell Res. pmid:9184073
Stotland MA and Kerrigan CL The role of platelet-activating factor in musculocutaneous flap reperfusion injury. 1997 Plast. Reconstr. Surg. pmid:9180723
Kelefiotis D and Vakirtzi-Lemonias C Kinetics of PAF transfer, distribution and metabolism in human blood in vitro. 1997 Life Sci. pmid:9180364
Vasänge M et al. A sulphonoglycolipid from the fern Polypodium decumanum and its effect on the platelet activating-factor receptor in human neutrophils. 1997 J. Pharm. Pharmacol. pmid:9178195
Lin CN et al. 2',5'-Dihydroxychalcone as a potent chemical mediator and cyclooxygenase inhibitor. 1997 J. Pharm. Pharmacol. pmid:9178190