Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Naccache PH et al. Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. 1986 J. Leukoc. Biol. pmid:3021882
Toth PD and Mikulaschek AW Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. 1986 Circ. Shock pmid:3802423
O'Flaherty JT et al. Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. 1986 J. Immunol. pmid:3095426
Weber N [A platelet-activating factor--a physiologically active ether lipid]. 1986 Pharm Unserer Zeit pmid:3749211
Page CP et al. Inflammatory mediators of asthma. 1986 Eur J Respir Dis Suppl pmid:3527737
Roubin R et al. Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. 1986 J. Immunol. pmid:3950403
Oda M et al. Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. 1986 J. Biochem. pmid:3818574
Nishihira J and Ishibashi T A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. 1986 Lipids pmid:3821393
Lauri D et al. Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. 1986 Agents Actions pmid:3706054
Nijssen JG et al. Identification of a calcium-independent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether). 1986 Biochim. Biophys. Acta pmid:3707986
Fitzgerald MF et al. The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. 1986 Br. J. Pharmacol. pmid:3708213
Chand N et al. The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. 1986 Eur. J. Pharmacol. pmid:3709669
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Issekutz AC and Ripley M The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. 1986 Am. J. Hematol. pmid:2934975
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
Benhamou M et al. Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. 1986 J. Immunol. pmid:2935578
D'Humières S et al. PAF-acether-induced synthesis of prostacyclin by human endothelial cells. 1986 Eur. J. Pharmacol. pmid:3102256
Chung KF et al. Airway hyperresponsiveness induced by platelet-activating factor: role of thromboxane generation. 1986 J. Pharmacol. Exp. Ther. pmid:3005546
Morley J Platelet activating factor and asthma. 1986 Agents Actions pmid:3099555
Orchard MA et al. Basophil histamine release induced by a substance from stimulated human platelets. 1986 J. Immunol. pmid:2419428
Anderson RC et al. Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. 1986 Chem. Phys. Lipids pmid:3948294
Tselepis A et al. Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. 1986 Biochem. Int. pmid:3099798
Hwang SB et al. Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. 1986 Eur. J. Pharmacol. pmid:3948914
Doyle VM et al. Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells. 1986 FEBS Lett. pmid:3949010
Wissner A et al. Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety. 1986 J. Med. Chem. pmid:3950913
Issekutz AC and Szpejda M Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. 1986 Lab. Invest. pmid:3951199
Shukla SD Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. 1986 Life Sci. pmid:3951330
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Okayasu T et al. Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. 1986 Biochim. Biophys. Acta pmid:3947669
Patscheke H and Dierichs R Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. 1986 Eur. J. Cell Biol. pmid:3084260
Billah MM et al. Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation. 1986 J. Biol. Chem. pmid:3084473
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Foegh ML et al. Fatty acids and eicosanoids in organ transplantation. 1986 Prog. Lipid Res. pmid:3321095
Herrmann DB et al. Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. 1986 Biochim. Biophys. Acta pmid:3947667
Söling HD and Fest W Synthesis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in exocrine glands and its control by secretagogues. 1986 J. Biol. Chem. pmid:3095313
Ostermann G et al. The role of lipoproteins in the degradation of platelet-activating factor. 1986 Thromb. Res. pmid:3798402
Jackson CV et al. Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. 1986 Circ. Res. pmid:2868810
Gordeev KIu et al. [Synthesis of thioanalogs of platelet activating factor (PAF)]. 1986 Bioorg. Khim. pmid:3768051
Hoffman DR et al. Metabolism and function of platelet-activating factor in fetal rabbit lung development. 1986 Biochim. Biophys. Acta pmid:3768390
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. 1986 Chem. Pharm. Bull. pmid:3769104
Ohga Y and Nakanishi M Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor. 1986 FEBS Lett. pmid:3770190
Ramesha CS and Pickett WC Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. 1986 J. Biol. Chem. pmid:3096991
Patterson R et al. Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3770978
Smith PF et al. The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. 1986 Immunopharmacology pmid:3771195
Kawaguchi H and Yasuda H Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. 1986 Hypertension pmid:3081442
Thomas Y et al. [Synthesis of paf-acether by E. coli K12]. 1986 C. R. Acad. Sci. III, Sci. Vie pmid:3101984
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Hwang SB et al. Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. 1986 J. Biol. Chem. pmid:3001070
Buxton DB et al. Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 J. Biol. Chem. pmid:3001074