Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
Hallam TJ et al. | Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. | 1984 | Biochem. J. | pmid:6426464 |
Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
Baldi E et al. | Stimulation of platelet-activating factor synthesis by progesterone and A23187 in human spermatozoa. | 1993 | Biochem. J. | pmid:8503848 |
Salari H et al. | Translocation-independent activation of protein kinase C by platelet-activating factor, thrombin and prostacyclin. Lack of correlation with polyphosphoinositide hydrolysis in rabbit platelets. | 1990 | Biochem. J. | pmid:2160234 |
Seifert R et al. | Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. | 1990 | Biochem. J. | pmid:2160237 |
MacIntyre DE and Pollock WK | Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets. | 1983 | Biochem. J. | pmid:6411067 |
Tou J et al. | Accumulation of phosphatidic acid mass and increased de novo synthesis of glycerolipids in platelet-activating-factor-activated human neutrophils. | 1991 | Biochem. J. | pmid:1662484 |
Wang H et al. | Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. | 1997 | Biochem. J. | pmid:9065783 |
Triggiani M et al. | Factors that influence the proportions of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by the mast cell. | 1992 | Biochem. J. | pmid:1530582 |
Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |
McKean ML and Silver MJ | Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. | 1985 | Biochem. J. | pmid:3919710 |
Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
Altin JG and Bygrave FL | Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. | 1988 | Biochem. J. | pmid:3128268 |
Chao W et al. | Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187. | 1989 | Biochem. J. | pmid:2494988 |
O'Flaherty JT et al. | Roles of Ca2+ in human neutrophil responses to receptor agonists. | 1991 | Biochem. J. | pmid:1651699 |
Dohi T et al. | Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells. | 1991 | Biochem. J. | pmid:1645529 |
Cluzel M et al. | Dynamics of platelet-activating-factor release and uptake in a human neutrophil suspension. | 1991 | Biochem. J. | pmid:1898338 |
Murphy CT and Westwick J | Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. | 1994 | Biochem. J. | pmid:8042999 |
DiCorleto PE and de la Motte CA | Thrombin causes increased monocytic-cell adhesion to endothelial cells through a protein kinase C-dependent pathway. | 1989 | Biochem. J. | pmid:2513808 |
O'Flaherty JT et al. | Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. | 1992 | Biochem. J. | pmid:1332696 |
Chao W et al. | Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells. | 1989 | Biochem. J. | pmid:2775221 |
Dulioust A et al. | Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages. | 1989 | Biochem. J. | pmid:2513801 |
Winkler JD et al. | Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. | 1993 | Biochem. J. | pmid:8387780 |
Rogers JE et al. | Solubilization of a functionally active platelet-activating factor receptor from rabbit platelets. | 1991 | Biochem. J. | pmid:1654881 |
Hii CS et al. | Basal and phorbol-ester-stimulated turnover of phosphatidylcholine in HeLa cells involve different pathways. | 1992 | Biochem. J. | pmid:1335237 |
Snyder F | Platelet-activating factor: the biosynthetic and catabolic enzymes. | 1995 | Biochem. J. | pmid:7848265 |
Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
Halenda SP and Rehm AG | Evidence for the calcium-dependent activation of phospholipase D in thrombin-stimulated human erythroleukaemia cells. | 1990 | Biochem. J. | pmid:2159285 |
Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
Grigg ME et al. | Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis. | 1996 | Biochem. J. | pmid:8713083 |
Yousufzai SY and Abdel-Latif AA | Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. | 1985 | Biochem. J. | pmid:3927898 |
Schwaner I et al. | Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. | 1992 | Biochem. J. | pmid:1310589 |
Tran K et al. | Vitamin E enhances the acylation of 1-O-alkyl-sn-glycero-3-phosphocholine in human endothelial cells. | 1994 | Biochem. J. | pmid:8129709 |
Gandhi CR et al. | A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. | 1992 | Biochem. J. | pmid:1310601 |
Montero M et al. | Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator. | 1992 | Biochem. J. | pmid:1463455 |
Hashizume T et al. | Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism. | 1992 | Biochem. J. | pmid:1540140 |
Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
Joly F et al. | Biosynthesis of paf-acether. Activators of protein kinase C stimulate cultured mast cell acetyltransferase without stimulating paf-acether synthesis. | 1990 | Biochem. J. | pmid:2146953 |
Fouda SI et al. | Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2. | 1995 | Biochem. J. | pmid:8948437 |
Tao W et al. | Arachidonic acid release in rabbit neutrophils. | 1989 | Biochem. J. | pmid:2494986 |
Vallance SJ et al. | Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na+/H+ antiport. Evidence for two distinct roles for Na+/H+ antiport activation. | 1990 | Biochem. J. | pmid:2154185 |
Kimura K et al. | Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins. | 1992 | Biochem. J. | pmid:1317164 |
Chau LY et al. | Agonist-induced down-regulation of platelet-activating factor receptor gene expression in U937 cells. | 1994 | Biochem. J. | pmid:7519853 |
Dunlop ME and Larkins RG | Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet-activating factor and endothelin is attenuated by prostaglandin E2. | 1990 | Biochem. J. | pmid:2268285 |
Montero M et al. | Agonist-induced Ca2+ influx in human neutrophils is secondary to the emptying of intracellular calcium stores. | 1991 | Biochem. J. | pmid:1906712 |
Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
Herbert JM | Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. | 1992 | Biochem. J. | pmid:1318021 |
Raggers RJ et al. | Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. | 2001 | Biochem. J. | pmid:11463358 |
Garcia MC et al. | Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid. | 1990 | Biochem. J. | pmid:1693077 |
Huang SJ et al. | Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. | 1988 | Biochem. J. | pmid:2833227 |
van Willigen G and Akkerman JW | Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. | 1991 | Biochem. J. | pmid:1846526 |
Church DJ et al. | Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes. | 1993 | Biochem. J. | pmid:8452537 |
Chao W and Olson MS | Platelet-activating factor: receptors and signal transduction. | 1993 | Biochem. J. | pmid:8391253 |
Murphy CT and Westwick J | Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. | 1992 | Biochem. J. | pmid:1567363 |
Garcia MC et al. | Metabolism of platelet-activating factor in human haematopoietic cell lines. Differences between myeloid and lymphoid cells. | 1991 | Biochem. J. | pmid:1847616 |
van Willigen G et al. | Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. | 1996 | Biochem. J. | pmid:8615768 |
Pelosin JM et al. | Production of platelet-activating factor is a component of the angiotensin II-protein kinase C activation pathway in bovine adrenocortical cells. | 1991 | Biochem. J. | pmid:1883337 |
Sebaldt RJ et al. | Quantification of contributions of phospholipid precursors to diradylglycerols in stimulated mononuclear phagocytes. | 1992 | Biochem. J. | pmid:1599420 |
Churchill L et al. | Interaction of platelet-activating factor with cultured guinea pig tracheal epithelial cells. | 1991 | Biochem. J. | pmid:2064601 |
Tripathi YB et al. | Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells. | 1992 | Biochem. J. | pmid:1382409 |
Krump E et al. | Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx. | 1995 | Biochem. J. | pmid:7654211 |
Evans RD et al. | Metabolic effects of platelet-activating factor in rats in vivo. Stimulation of hepatic glycogenolysis and lipogenesis. | 1990 | Biochem. J. | pmid:2165397 |
Bushfield M et al. | Inhibition of platelet-activating-factor-induced human platelet activation by prostaglandin D2. Differential sensitivity of platelet transduction processes and functional responses to inhibition by cyclic AMP. | 1985 | Biochem. J. | pmid:3002327 |
Altin JG et al. | Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and L-alpha-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. | 1987 | Biochem. J. | pmid:3117040 |
Evans RD et al. | Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia. | 1991 | Biochem. J. | pmid:1747129 |
Kloprogge E and Akkerman JW | Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. | 1986 | Biochem. J. | pmid:3101672 |
Burgers JA and Akkerman JW | Regulation of the receptor for platelet-activating factor on human platelets. | 1993 | Biochem. J. | pmid:8385926 |
Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |
Wu J et al. | Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. | 2006 | Biochem. J. | pmid:16255717 |
Soubeyrand S et al. | Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase. | 1998 | Biochem. J. | pmid:9405273 |
Coffer PJ et al. | Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. | 1998 | Biochem. J. | pmid:9405284 |
Turner JS et al. | Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. | 1994 | Biochem. J. | pmid:8280096 |
Antonopoulou S et al. | Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. | 1998 | Biochem. J. | pmid:9480892 |
Takano H et al. | Platelet aggregation induced by platelet-activating factor is suppressed by cystine protease inhibitor. | 1991 | Biochem. Med. Metab. Biol. | pmid:2015107 |
Akiba S et al. | Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9891858 |
Tanfani F et al. | A sensitive detection of neutrophil activation by fluorescence quenching of membrane inserted singlet oxygen probe. | 1994 | Biochem. Mol. Biol. Int. | pmid:8061626 |
Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
Suzuki H et al. | Evidence for the production of platelet-activating factor by murine embryos and its putative role in the maternal physiology. | 1995 | Biochem. Mol. Biol. Int. | pmid:8589634 |
Ventura MA et al. | The adhesiveness of monocytic U937 cells is stimulated by pro-inflammatory agents and inhibited by adenosine 3':5'-cyclic monophosphate. | 1990 | Biochem. Pharmacol. | pmid:2154991 |
Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
Yamada K et al. | Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. | 1988 | Biochem. Pharmacol. | pmid:3128296 |
Edwards MC et al. | Secretion and properties of a polypeptide factor generated by phorbol ester stimulation of human blood platelets. | 1987 | Biochem. Pharmacol. | pmid:3606649 |
Tanizawa H and Tai HH | Synergism between chemotactic peptide and platelet-activating factor in stimulating thromboxane B2 and leukotriene B4 biosynthesis in human neutrophils. | 1989 | Biochem. Pharmacol. | pmid:2547385 |
Daniels RH et al. | Differential regulation of early phase and late phase responses in human neutrophils by cAMP. | 1993 | Biochem. Pharmacol. | pmid:8387301 |
McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
Dewald B and Baggiolini M | Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. | 1987 | Biochem. Pharmacol. | pmid:3649232 |
Sugatani J et al. | Inhibition of rabbit platelet aggregation by nucleoside 5'-alkylphosphates: correlation with inhibition of agonist-induced calcium influx. | 2000 | Biochem. Pharmacol. | pmid:10825464 |
Agarwal KC et al. | Platelet-activating factor (PAF)-induced platelet aggregation. Modulation by plasma adenosine and methylxanthines. | 1994 | Biochem. Pharmacol. | pmid:7986202 |
Shibata K et al. | Ca2+ entry induced by calcium influx factor and its regulation by protein kinase C in rabbit neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8678902 |
Pretolani M et al. | From anti-asthma drugs to PAF-acether antagonism and back. Present status. | 1989 | Biochem. Pharmacol. | pmid:2655601 |
Anderson R et al. | Membrane stabilizing, anti-oxidative interactions of propranolol and dexpropranolol with neutrophils. | 1996 | Biochem. Pharmacol. | pmid:8694859 |
Lohmeyer M et al. | Stimulation of intracellular free calcium increases by platelet-activating factor in HT29 colon carcinoma cells. Spectrofluorimetric and preliminary spatio-temporal analysis using confocal laser scanning fluorescence imaging microscopy. | 1994 | Biochem. Pharmacol. | pmid:8147917 |
O'Flaherty JT | Phospholipid metabolism and stimulus-response coupling. | 1987 | Biochem. Pharmacol. | pmid:3030324 |
Khandwala A et al. | REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. | 1987 | Biochem. Pharmacol. | pmid:2435293 |