Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Podolak-Dawidziak M [Role of white cells and neoplastic cells in haemostasis]. 2002 Pol. Arch. Med. Wewn. pmid:12189915
Strømgaard K et al. Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. 2002 J. Med. Chem. pmid:12190325
Wong RK et al. Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. 2002 Diabetes pmid:12196480
Goldring WP and Pattenden G A total synthesis of phomactin A. 2002 Chem. Commun. (Camb.) pmid:12196974
Ewer AK Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. 2002 Acta Paediatr Suppl pmid:12200892
Göggel R et al. Platelet-activating factor-induced pulmonary edema is partly mediated by prostaglandin E(2), E-prostanoid 3-receptors, and potassium channels. 2002 Am. J. Respir. Crit. Care Med. pmid:12204861
Bazan H and Ottino P The role of platelet-activating factor in the corneal response to injury. 2002 Prog Retin Eye Res pmid:12207945
Bussolati B et al. Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. 2002 Int. J. Cancer pmid:12209602
Cadwallader KA et al. Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. 2002 J. Immunol. pmid:12218155
Cuschieri J et al. Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. 2002 Surgery pmid:12219006
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Bussolati B et al. Nitric oxide/platelet activating factor cross-talk in mesangial cells modulates the interaction with leukocytes. 2002 Kidney Int. pmid:12234302
Weyrich AS et al. Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. 2002 Circulation pmid:12234942
Han SJ et al. Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). 2002 J. Biol. Chem. pmid:12235132
Akai T et al. Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. 2002 J. Neurooncol. pmid:12241114
Donnard M et al. Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. 2002 Stem Cells pmid:12351810
Leung SW et al. Platelet-activating factor enhanced the pressor response of endothelin-1. 2002 J. Cardiovasc. Pharmacol. pmid:12352314
Brewer C et al. Platelet activating factor-induced apoptosis is inhibited by ectopic expression of the platelet activating factor G-protein coupled receptor. 2002 J. Neurochem. pmid:12354298
Marin V et al. Chemotactic agents induce IL-6Ralpha shedding from polymorphonuclear cells: involvement of a metalloproteinase of the TNF-alpha-converting enzyme (TACE) type. 2002 Eur. J. Immunol. pmid:12355450
Beauchamp MH et al. Platelet-activating factor in vasoobliteration of oxygen-induced retinopathy. 2002 Invest. Ophthalmol. Vis. Sci. pmid:12356842
Downing SJ et al. Effect of platelet-activating factor on the electrophysiology of the human Fallopian tube: early mediation of embryo-maternal dialogue? 2002 Reproduction pmid:12361471
Teather LA et al. Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. 2002 Psychopharmacology (Berl.) pmid:12373444
Baker PR et al. Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. 2002 Biochim. Biophys. Acta pmid:12379481
Michibayashi T Platelet aggregating response to platelet activating factor participates in activation of the 12-lipoxygenase pathway in platelets from rabbits. 2002 Int Angiol pmid:12384648
Shigematsu S et al. Bradykinin-induced proinflammatory signaling mechanisms. 2002 Am. J. Physiol. Heart Circ. Physiol. pmid:12388246
Maul H et al. Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. 2002 Am. J. Obstet. Gynecol. pmid:12388958
Murohisa G et al. Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. 2002 Liver pmid:12390475
Kato M et al. Platelet-activating factor activates two distinct effector pathways in human eosinophils. 2002 J. Immunol. pmid:12391244
Ueno H et al. Coagulation/fibrinolysis abnormality and vascular endothelial damage in the pathogenesis of thrombocytopenic multiple organ failure. 2002 Crit. Care Med. pmid:12394951
Sibelius U et al. Distinct pathways of lipopolysaccharide priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity to interleukin-10. 2002 Crit. Care Med. pmid:12394960
Sakamoto H et al. Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. 2002 J. Biol. Chem. pmid:12397078
Ibe BO et al. Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. 2002 Mol. Genet. Metab. pmid:12409272
Childs EW et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. 2002 Shock pmid:12412620
Farbiszewski R et al. [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. 2002 Jul-Aug Neurol. Neurochir. Pol. pmid:12418143
Eikelboom JW et al. Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. 2002 Eur. Heart J. pmid:12419297
Tanaka S and Koike T Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. 2002 Glia pmid:12420315
Maniscalco M et al. Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. 2002 Eur. J. Clin. Invest. pmid:12423328
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Dun Y et al. Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. 2002 Methods Find Exp Clin Pharmacol pmid:12428428
Fallani A et al. Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. 2002 Prostaglandins Other Lipid Mediat. pmid:12428690
Gélinas DS et al. Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. 2002 Br. J. Pharmacol. pmid:12429574
Mahmoud FF et al. In vitro effects of ginkgolide B combined with cyclosporin A on T-lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects. 2002 Transplant. Proc. pmid:12431672
Arai H Platelet-activating factor acetylhydrolase. 2002 Prostaglandins Other Lipid Mediat. pmid:12432911
Ishii S et al. Platelet-activating factor receptor. 2002 Prostaglandins Other Lipid Mediat. pmid:12432946
Lee YM et al. Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. 2002 J. Lab. Clin. Med. pmid:12434132
Abu-Zidan FM and Windsor JA Lexipafant and acute pancreatitis: a critical appraisal of the clinical trials. 2002 Eur J Surg pmid:12440758
Pawliczak R et al. Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway. 2002 Am. J. Respir. Cell Mol. Biol. pmid:12444032
MacKinnon AC et al. Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. 2002 J. Immunol. pmid:12444147
Marrache AM et al. Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. 2002 J. Immunol. pmid:12444157
Pacheco P et al. Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. 2002 J. Immunol. pmid:12444160