Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Yamazaki H [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. 1986 Nippon Naika Gakkai Zasshi pmid:3027214
Prunieras M Melanocytes, melanogenesis, and inflammation. 1986 Int. J. Dermatol. pmid:2433237
Schleimer RP et al. Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. 1986 J. Immunol. pmid:3082976
Etienne A et al. In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. 1986 Agents Actions pmid:3515870
Nunez D et al. Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. 1986 Eur. J. Pharmacol. pmid:3086108
Oxholm P and Winther K Thrombocyte involvement in immune inflammatory reactions. 1986 Allergy pmid:3515999
DeFeudis FV Possible relationship between the syntheses of endothelium-derived relaxing factor (EDRF) and PAF-acether. 1986 Gen. Pharmacol. pmid:3516791
Camussi G Potential role of platelet-activating factor in renal pathophysiology. 1986 Kidney Int. pmid:3517457
Mastacchi R et al. Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. 1986 Agents Actions pmid:3518359
Zanetti A et al. The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. 1986 Eur. J. Pharmacol. pmid:2944757
Tetta C et al. Platelet-activating factor contracts human myometrium in vitro. 1986 Proc. Soc. Exp. Biol. Med. pmid:3797421
Montrucchio G et al. In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. 1986 Prostaglandins pmid:3797692
Bourgain RH et al. Vivo effects of PAF-acether and arterial thrombosis. 1986 Adv. Exp. Med. Biol. pmid:3799334
Kloprogge E et al. PAF-acether (1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphocholine)-induced fibrinogen binding to platelets depends on metabolic energy. 1986 Biochem. J. pmid:3800968
Panchenko EP et al. [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. 1986 Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR pmid:3801147
Wardlaw AJ et al. Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. 1986 J. Clin. Invest. pmid:3023451
Sybertz EJ et al. AGEPC, a vasodilator phospholipid with profound circulatory actions. 1986 Prog. Clin. Biol. Res. pmid:3538024
McGowan HM et al. Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. 1986 Am. J. Physiol. pmid:3538908
Hemmendinger S et al. [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. 1986 Ann. Biol. Clin. (Paris) pmid:3538949
Malavasi F et al. Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3085094
Orozco C et al. Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. 1986 J. Reprod. Fertil. pmid:3806515
Wissner A et al. Analogues of platelet activating factor. 5. Multiple oxygen substitution of the alkoxy chain. 1986 J. Med. Chem. pmid:3806583
Simpson AW et al. Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. 1986 FEBS Lett. pmid:3086128
Nakaya H and Tohse N Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. 1986 Br. J. Pharmacol. pmid:3814909
Alloatti G et al. Effect of platelet-activating factor (PAF) on human cardiac muscle. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3941007
Wade PJ et al. Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. 1986 Thromb. Res. pmid:3961730
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Okayasu T et al. Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. 1986 Biochim. Biophys. Acta pmid:3947669
Fisher RA et al. Effects of beta-adrenergic stimulation on 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 J. Biol. Chem. pmid:3013865
Darius H et al. Inhibition of the platelet activating factor mediated component of guinea pig anaphylaxis by receptor antagonists. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3015804
Kloprogge E et al. Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. 1986 J. Biol. Chem. pmid:3015954
O'Flaherty JT et al. Binding and metabolism of platelet-activating factor by human neutrophils. 1986 J. Clin. Invest. pmid:3016027
Burhop KE et al. Platelet-activating factor increases lung vascular permeability to protein. 1986 J. Appl. Physiol. pmid:3804927
Cox CP Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. 1986 Thromb. Res. pmid:2421432
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. 1986 Chem. Pharm. Bull. pmid:2421923
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. 1986 Chem. Pharm. Bull. pmid:2421924
Robertson DN and Smith GM CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. 1986 Eur. J. Pharmacol. pmid:3709663
Ostermann G et al. Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. 1986 Thromb. Res. pmid:3764811
Mehta J et al. Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. 1986 Prostaglandins Leukot Med pmid:3456620
McIntyre TM et al. Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3457383
Oh S et al. Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. 1986 Prostaglandins Leukot Med pmid:3459197
Newhouse MT and Sears MR Platelet activating factor, ketotifen and asthma. 1986 N. Z. Med. J. pmid:3462569
Chignard M et al. Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3464972
Kloprogge E and Akkerman JW Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. 1986 Biochem. J. pmid:3101672
Han GQ et al. [Neolignans from Piper hancei Maxim]. 1986 Yao Xue Xue Bao pmid:3776545
Koltai M et al. Effect of BN 52021, a specific PAF-acether antagonist, on cardiac anaphylaxis in Langendorff hearts isolated from passively sensitized guinea-pigs. 1986 Eur. J. Pharmacol. pmid:3780855
Montrucchio G et al. Cardiovascular alterations in the rabbit infused with platelet activating factor (PAF): effect of kadsurenone, a PAF-receptor antagonist. 1986 Int J Tissue React pmid:3025124
Salari H Solid-phase extraction and reversed-phase high-performance liquid chromatographic technique for isolation and estimation of platelet activating factor in plasma. 1986 J. Chromatogr. pmid:3782417
Ng DS and Wong K GTP regulation of platelet-activating factor binding to human neutrophil membranes. 1986 Biochem. Biophys. Res. Commun. pmid:3026378