Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Nagase T et al. Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. 1999 J. Clin. Invest. pmid:10525045
Prescott SM et al. Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. 1999 J. Clin. Invest. pmid:10525039
Monteiro HS et al. Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. 1999 Pharmacol. Toxicol. pmid:10522748
Hocke M et al. Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. 1999 Jul-Aug Hepatogastroenterology pmid:10521992
Sugiura T et al. Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. 1999 Biochim. Biophys. Acta pmid:10521703
Bernatchez PN et al. Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. 1999 J. Biol. Chem. pmid:10521504
Greenberg SG and Clark KE Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. 1999 Am. J. Physiol. pmid:10516237
Merendino N et al. Human intestinal epithelial cells express receptors for platelet-activating factor. 1999 Am. J. Physiol. pmid:10516147
Peplow PV Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10509861
Tiemann U et al. Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. 1999 J. Reprod. Fertil. pmid:10505057
Min JH et al. Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. 1999 Biochemistry pmid:10504265
Imrie CW and McKay CJ The scientific basis of medical therapy of acute pancreatitis. Could it work, and is there a role for lexipafant? 1999 Gastroenterol. Clin. North Am. pmid:10503138
Sakaguchi T et al. Participation of platelet-activating factor in the lipopolysaccharide-induced liver injury in partially hepatectomized rats. 1999 Hepatology pmid:10498648
Marathe GK et al. Inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. 1999 J. Biol. Chem. pmid:10497200
Mitidieri F and de Meis L Ca(2+) release and heat production by the endoplasmic reticulum Ca(2+)-ATPase of blood platelets. Effect of the platelet activating factor. 1999 J. Biol. Chem. pmid:10497193
Dekkers PE et al. Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. 1999 Infect. Immun. pmid:10496934
GamaleÄ­ IA et al. [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. 1999 Tsitologiia pmid:10496012
Comellas A et al. Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. 1999 J. Physiol. Biochem. pmid:10494654
Blackstone MO ICAM-1 in cerulein-induced pancreatitis. 1999 Gastroenterology pmid:10490367
Triggiani M et al. Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine. 1999 Biochem. Pharmacol. pmid:10487538
Piccolo MT et al. Chemotactic mediator requirements in lung injury following skin burns in rats. 1999 Exp. Mol. Pathol. pmid:10486240
Koyama N and Ogawa Y Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. 1999 Eur. J. Pediatr. pmid:10486094
Kültürsay N et al. Platelet-activating factor concentrations in healthy and septic neonates. 1999 Eur. J. Pediatr. pmid:10485307
Shah BH et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. 1999 Biochem. Pharmacol. pmid:10484074
Kapui Z et al. Experimental studies on guanosine 3',5'-cyclic monophosphate levels and airway responsiveness of the novel phosphodiesterase type 5 inhibitor SR 265579 in guinea-pigs. 1999 Arzneimittelforschung pmid:10483515
Nakasaki T et al. Effects of PAF on histamine H1 receptor mRNA expression in rat trigeminal ganglia. 1999 Prostaglandins Other Lipid Mediat. pmid:10482285
Calcerrada MC et al. Modulation of protein kinase C isoforms by PAF in cerebral cortex. 1999 Prostaglandins Other Lipid Mediat. pmid:10482284
Foitzik T et al. Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. 1999 May-Jun J. Gastrointest. Surg. pmid:10481117
Casale TB et al. Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. 1999 Ann. Allergy Asthma Immunol. pmid:10480585
Oku H and Ishiguro K Screening method for PAF antagonist substances: on the phenolic compounds from Impatients balsamina L. 1999 Phytother Res pmid:10479766
Baker KE and Curtis MJ Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. 1999 J. Cardiovasc. Pharmacol. pmid:10470998
Denham W and Norman J The potential role of therapeutic cytokine manipulation in acute pancreatitis. 1999 Surg. Clin. North Am. pmid:10470326
Ho YS et al. Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. 1999 Protein Eng. pmid:10469831
Conroy DM and Sirois P Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. 1999 Inflammation pmid:10466580
Kaminski JJ et al. Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 1999 Bioorg. Med. Chem. pmid:10465415
Hsueh W et al. Necrotizing enterocolitis of the newborn: pathogenetic concepts in perspective. 1998 Jan-Feb Pediatr. Dev. Pathol. pmid:10463267
Zardini DM et al. Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. 1999 Cell Calcium pmid:10463102
Rengan R and Omann GM Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10462500
Downing SJ et al. Effect of inflammatory mediators on the electrophysiology of the human oviduct. 1999 Biol. Reprod. pmid:10456842
Yaffe MB et al. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. 1999 Surgery pmid:10455891
Subbanagounder G et al. Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. 1999 Circ. Res. pmid:10455059
Nikbakht-Sangari M et al. Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. 1999 Immunol. Invest. pmid:10454000
Dervenis C et al. Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. 1999 Int. J. Pancreatol. pmid:10453421
Sakaguchi T et al. Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. 1999 J. Surg. Res. pmid:10452877
Partrick DA et al. Cardiopulmonary bypass renders patients at risk for multiple organ failure via early neutrophil priming and late neutrophil disability. 1999 J. Surg. Res. pmid:10452867
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Birk-Sørensen L et al. Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. 1999 Scand J Plast Reconstr Surg Hand Surg pmid:10450571
Wang H et al. Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. 1999 Immunology pmid:10447766
Alvi SA et al. The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. 1999 Immunology pmid:10447739
Davies D et al. VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. 1999 Immunology pmid:10447726