Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Infertility, Male D007248 11 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Edema D004487 152 associated lipids
Brain Injuries D001930 4 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Osteonecrosis D010020 5 associated lipids
Hypotension D007022 41 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Lymphoma D008223 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Thyroid Neoplasms D013964 33 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Thalassemia D013789 8 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Nervous System Diseases D009422 37 associated lipids
Psoriasis D011565 47 associated lipids
Brain Edema D001929 20 associated lipids
Leukopenia D007970 9 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Burns, Inhalation D002059 4 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Fetal Weight D020567 12 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Stroke D020521 32 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemia D007511 18 associated lipids
Colonic Diseases D003108 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Zhao XY et al. [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. 2003 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:12970925
Lamparter E and Lunkenheimer CH The automation of dissolution testing of solid oral dosage forms. 1992 Oct-Dec J Pharm Biomed Anal pmid:1298375
Cheng NN et al. [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. 1992 Yao Xue Xue Bao pmid:1299136
Wong B et al. Identification of a membrane-associated 1-0-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine hydrolyzing phospholipase A2 in guinea pig 1 epidermis. Implications in the cutaneous biosynthesis of platelet-activating factor. 1992 FEBS Lett. pmid:1299618
Wu QX [Amplification and desensitization in platelet activation]. 1992 Sheng Li Ke Xue Jin Zhan pmid:1299958
Doly M et al. Inhibition of vincristine-induced retinal impairments by a specific PAF antagonist. 1992 Lens Eye Toxic Res pmid:1301801
Nijkamp FP et al. Reversal of the endotoxin-induced bronchial hyperreactivity to histamine by the platelet activating factor antagonist BN 52021. 1992 Pneumonol Alergol Pol pmid:1305483
Hirano T and Manabe T "Cocktail" therapy for acute pancreatitis: combined therapy of protease inhibitor, xanthine oxidase inhibitor and platelet activating factor antagonist in rat caerulein-induced pancreatis. 1992 Nihon Geka Hokan pmid:1306981
Li Q [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. 1992 Zhonghua Jie He He Hu Xi Za Zhi pmid:1307517
Klöcking HP Inhibition of PAF-induced tPA release by KO-286011. 1992 Ann. N. Y. Acad. Sci. pmid:1309038
Zoratti EM et al. Platelet-activating factor primes human eosinophil generation of superoxide. 1992 Am. J. Respir. Cell Mol. Biol. pmid:1309421
van Willigen G and Akkerman JW Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with alpha-thrombin. 1992 Blood pmid:1309427
Bratton DL et al. The mechanism of internalization of platelet-activating factor in activated human neutrophils. Enhanced transbilayer movement across the plasma membrane. 1992 J. Immunol. pmid:1309560
Ono S and Voelkel NF PAF receptor blockade inhibits lung vascular changes in the rat monocrotaline model. 1992 Lung pmid:1310128
Schwaner I et al. Receptor-mediated increases in cytosolic Ca2+ in the human erythroleukaemia cell line involve pertussis toxin-sensitive and -insensitive pathways. 1992 Biochem. J. pmid:1310589
Gandhi CR et al. A comparative study of endothelin- and platelet-activating-factor-mediated signal transduction and prostaglandin synthesis in rat Kupffer cells. 1992 Biochem. J. pmid:1310601
Jagels MA and Hugli TE Neutrophil chemotactic factors promote leukocytosis. A common mechanism for cellular recruitment from bone marrow. 1992 J. Immunol. pmid:1310708
Földes-Filep E et al. C-reactive protein inhibits intracellular calcium mobilization and superoxide production by guinea pig alveolar macrophages. 1992 J. Leukoc. Biol. pmid:1311010
Yue TL et al. Platelet-activating factor stimulates phosphoinositide turnover in neurohybrid NCB-20 cells: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins and inhibition by protein kinase C. 1992 Mol. Pharmacol. pmid:1311408
Grandoni KM et al. Trichothecene mycotoxins inhibit phosphoinositide hydrolysis in bovine platelets stimulated with platelet activating factor. 1992 Toxicology pmid:1311467
Wu T et al. Endothelin-1 stimulates eicosanoid production in cultured human nasal mucosa. 1992 Am. J. Respir. Cell Mol. Biol. pmid:1311593
Catalán RE et al. PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. 1992 Biochem. Biophys. Res. Commun. pmid:1311925
Shukla SD Platelet-activating factor receptor and signal transduction mechanisms. 1992 FASEB J. pmid:1312046
Aepfelbacher M et al. Bacterial lipopolysaccharide up-regulates platelet-activating factor-stimulated Ca2+ mobilization and eicosanoid release in human Mono Mac 6 cells. 1992 J. Immunol. pmid:1312103
Henson PM et al. NHLBI workshop summary. Platelet-activating factor: role in pulmonary injury and dysfunction and blood abnormalities. 1992 Am. Rev. Respir. Dis. pmid:1312316
Alonso MT et al. Effects of the antithrombitic agent PCA 4230 on agonist-induced Ca2+ entry and Ca2+ release in human platelets. 1992 Biochim. Biophys. Acta pmid:1312357
Bazan NG Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. 2003 J. Lipid Res. pmid:13130128
Chatterjee SS et al. Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. 2003 Pharmacopsychiatry pmid:13130392
e Silva PM et al. Nedocromil sodium prevents in vivo generation of the eosinophilotactic substance induced by PAF but fails to antagonize its effects. 1992 Br. J. Pharmacol. pmid:1313729
Schaberg T et al. Superoxide anion release induced by platelet-activating factor is increased in human alveolar macrophages from smokers. 1992 Eur. Respir. J. pmid:1314191
Zhu YP et al. The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. 1992 Am. J. Obstet. Gynecol. pmid:1314480
Rabinovici R et al. Platelet activating factor mediates interleukin-2-induced lung injury in the rat. 1992 J. Clin. Invest. pmid:1314853
Zarco P et al. Involvement of platelet-activating factor and tumour necrosis factor in the pathogenesis of joint inflammation in rabbits. 1992 Clin. Exp. Immunol. pmid:1315229
Kuijpers TW et al. Neutrophil migration across monolayers of cytokine-prestimulated endothelial cells: a role for platelet-activating factor and IL-8. 1992 J. Cell Biol. pmid:1315317
Carveth HJ et al. Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. 1992 Semin. Thromb. Hemost. pmid:1315452
Adler KB et al. Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism. 1992 Am. J. Respir. Cell Mol. Biol. pmid:1316134
Morland CM et al. Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion. 1992 Am. J. Respir. Cell Mol. Biol. pmid:1316135
Koltai M et al. Role of PAF and cytokines in microvascular tissue injury. 1992 J. Lab. Clin. Med. pmid:1316420
Fukuchi Y et al. Low ligand binding activities of two distinct types of Fc gamma receptor on guinea-pig peripheral blood polymorphonuclear leukocytes are differentially improved by proteolysis or platelet activating factor. 1992 Mol. Immunol. pmid:1316550
Sehmi R et al. Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects. 1992 Blood pmid:1316789
Pinckard RN et al. Differential responsiveness of human neutrophils to the autocrine actions of 1-O-alkyl-homologs and 1-acyl analogs of platelet-activating factor. 1992 J. Immunol. pmid:1316919
Kimura K et al. Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins. 1992 Biochem. J. pmid:1317164
Joly F et al. Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. 1992 Biochem. Biophys. Res. Commun. pmid:1317174
Moreira-Ludewig R and Healy CT A rapid microtiter plate method for the detection of lysozyme release from human neutrophils. 1992 J Pharmacol Toxicol Methods pmid:1317227
Smith LJ Bioactive mediators in asthma. 1992 Chest pmid:1317278
Graham RM et al. Plasma platelet-activating factor degradation in patients with severe coronary artery disease. 1992 Clin. Sci. pmid:1317763
Guinn DE et al. Synthesis and structure-activity relationships of a series of novel benzopyran-containing platelet activating factor antagonists. 1992 J. Med. Chem. pmid:1317924
Herbert JM Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. 1992 Biochem. J. pmid:1318021
Hidi R et al. Formation of LTB4 by fMLP-stimulated alveolar macrophages accounts for eosinophil migration in vitro. 1992 J. Leukoc. Biol. pmid:1318347
Rediske JJ et al. Platelet activating factor stimulates intracellular calcium transients in human neutrophils: involvement of endogenous 5-lipoxygenase products. 1992 J. Leukoc. Biol. pmid:1318349