Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hecker G et al. | Potent inhibition of PAF-stimulated human platelets and polymorphonuclear leukocytes by the PGE1 analog OP-1206. | 1987 | Prog. Clin. Biol. Res. | pmid:2444988 |
Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
Sybertz EJ et al. | AGEPC, a vasodilator phospholipid with profound circulatory actions. | 1986 | Prog. Clin. Biol. Res. | pmid:3538024 |
Karpatkin S et al. | Platelet aggregating material (PAM) of two virally-transformed tumors: SV3T3 mouse fibroblast and PW20 rat renal sarcoma. Role of cell surface sialylation. | 1982 | Prog. Clin. Biol. Res. | pmid:7111309 |
Stjernschantz J and Bito LZ | The ocular effects of eicosanoids and other autacoids: historic background and the need for a broader perspective. | 1989 | Prog. Clin. Biol. Res. | pmid:2571999 |
Valone FH et al. | Mechanisms for biphasic or persistent immunologic reactions induced by platelet-activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2685826 |
Gasser H et al. | Effect of platelet-activating factor (PAF) administration in chronically instrumented sheep--analysis of PAF in plasma. | 1989 | Prog. Clin. Biol. Res. | pmid:2780708 |
Bonavida B et al. | The involvement of platelet-activating factor (PAF)-induced monocyte activation and tumor necrosis factor (TNF) production in shock. | 1989 | Prog. Clin. Biol. Res. | pmid:2780710 |
Heuer H | Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity. | 1989 | Prog. Clin. Biol. Res. | pmid:2780739 |
Bahrami S et al. | Effect of PAF-antagonists in endotoxin shock--ovine and rat experiments. | 1989 | Prog. Clin. Biol. Res. | pmid:2780740 |
Camussi G et al. | Anti-inflammatory peptides inhibit synthesis of platelet-activating factor. | 1990 | Prog. Clin. Biol. Res. | pmid:2204939 |
Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, and of eicosanoids- and PAF-acether antagonists on mortality and some biochemical parameters of three shock models. | 1989 | Prog. Clin. Biol. Res. | pmid:2798447 |
Bradley LM et al. | The role of lipid mediators in hypoxic pulmonary vasoconstriction in newborns. | 1989 | Prog. Clin. Biol. Res. | pmid:2798449 |
Mest HJ et al. | The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm. | 1989 | Prog. Clin. Biol. Res. | pmid:2798457 |
Baker RC | Ethanol modulation of the effects of platelet-activating factor on human platelets and a macrophage cell line. | 1990 | Prog. Clin. Biol. Res. | pmid:2300602 |
Pritze S et al. | Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro. | 1989 | Prog. Clin. Biol. Res. | pmid:2798458 |
Dembinska-Kiec A et al. | Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. | 1989 | Prog. Clin. Biol. Res. | pmid:2798459 |
Harper MJ et al. | Platelet-activating factor (PAF) and blastocyst-endometrial interactions. | 1989 | Prog. Clin. Biol. Res. | pmid:2542988 |
Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
Kelton JG et al. | The platelet aggregating factor(s) of thrombotic thrombocytopenic purpura. | 1990 | Prog. Clin. Biol. Res. | pmid:2191308 |
Heuer H and Casals-Stenzel J | The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086. | 1989 | Prog. Clin. Biol. Res. | pmid:2675077 |
Lefer AM | Platelet activating factor (PAF) and its role in cardiac injury. | 1989 | Prog. Clin. Biol. Res. | pmid:2678133 |
Levin M et al. | Platelet immune complex interaction in the pathogenesis of Kawasaki disease. | 1987 | Prog. Clin. Biol. Res. | pmid:3423040 |
Benveniste J | Paf-acether, an ether phospho-lipid with biological activity. | 1988 | Prog. Clin. Biol. Res. | pmid:3071808 |
Dulioust A et al. | Immunoregulatory functions of paf-acether (platelet-activating factor). | 1988 | Prog. Clin. Biol. Res. | pmid:3071809 |
Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
Schirmer WJ et al. | Systemic and renal hemodynamic response to platelet activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2726980 |
Dhainaut JF et al. | Platelet-activating factor antagonists as therapeutic strategy in sepsis. | 1994 | Prog. Clin. Biol. Res. | pmid:7831364 |
Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
Valone FH | Interrelationships among platelet-activating factor binding and metabolism and induction of platelet activation. | 1988 | Prog. Clin. Biol. Res. | pmid:2850575 |
Shukla SD and Morrison WJ | Platelet activating factor receptor occupancy in relation to activation and desensitization of phosphoinositide specific phospholipase C. | 1988 | Prog. Clin. Biol. Res. | pmid:2850576 |
Bazan NG | The neuromessenger platelet-activating factor in plasticity and neurodegeneration. | 1998 | Prog. Brain Res. | pmid:9932449 |
Bazan NG et al. | What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis. | 2002 | Prog. Brain Res. | pmid:12143339 |
Vernadakis A et al. | Role of astrocytes in aging: late passage primary mouse brain astrocytes and C-6 glial cells as models. | 1992 | Prog. Brain Res. | pmid:1287725 |
Bazan H and Ottino P | The role of platelet-activating factor in the corneal response to injury. | 2002 | Prog Retin Eye Res | pmid:12207945 |
Hosford D and Braquet P | Antagonists of platelet-activating factor: chemistry, pharmacology and clinical applications. | 1990 | Prog Med Chem | pmid:2217828 |
Bruni A and Palatini P | Biological and pharmacological properties of phospholipids. | 1982 | Prog Med Chem | pmid:6758038 |
Yoshida K et al. | PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. | 1988 | Prog Biochem Pharmacol | pmid:2457219 |
Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
Camussi G and Salvidio G | Platelet-activating factor in graft rejection. | 1988 | Prog Biochem Pharmacol | pmid:3043426 |
Hénocq E | PAF-acether and eosinophils. | 1988 | Prog Biochem Pharmacol | pmid:3043428 |
Lagente V and Fortes ZB | Role of PAF-acether in the vascular events of inflammation. | 1988 | Prog Biochem Pharmacol | pmid:3043429 |
Cordeiro RS et al. | Proinflammatory activity of platelet-activating factor: pharmacological modulation and cellular involvement. | 1988 | Prog Biochem Pharmacol | pmid:3043430 |
Pirotzky E and Braquet P | PAF-acether and kidney pathology. | 1988 | Prog Biochem Pharmacol | pmid:3043431 |
Feuerstein G and Siren AL | Platelet-activating factor and shock. | 1988 | Prog Biochem Pharmacol | pmid:3043432 |
Godfroid JJ and Heymans F | Chemistry of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043433 |
Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
Rola-Pleszczynski M | PAF in cellular immunology. | 1988 | Prog Biochem Pharmacol | pmid:3043437 |
Baggiolini M et al. | Effects of PAF on neutrophils and mononuclear phagocytes. | 1988 | Prog Biochem Pharmacol | pmid:3043438 |
Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
Pugsley MK et al. | The effects of platelet activating factor on isolated rat hearts. | 1990 | Proc. West. Pharmacol. Soc. | pmid:2274523 |
Paulson SK et al. | Pharmacologic characterization of the rabbit neutrophil receptor for platelet-activating factor. | 1990 | Proc. Soc. Exp. Biol. Med. | pmid:2172997 |
Reyes AA and Klahr S | Role of platelet-activating factor in renal function in normal rats and rats with bilateral ureteral obstruction. | 1991 | Proc. Soc. Exp. Biol. Med. | pmid:1891471 |
Tetta C et al. | Platelet-activating factor contracts human myometrium in vitro. | 1986 | Proc. Soc. Exp. Biol. Med. | pmid:3797421 |
Snyder F | Biochemistry of platelet-activating factor: a unique class of biologically active phospholipids. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2536942 |
Levy JV | Calmodulin antagonist W-7 inhibits aggregation of human platelets induced by platelet activating factor. | 1983 | Proc. Soc. Exp. Biol. Med. | pmid:6844347 |
Yamazaki M et al. | Phorbol 12-myristate 13-acetate inhibits binding of leukotriene B4 and platelet-activating factor and the responses they induce in neutrophils: site of action. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2548188 |
Müller E et al. | Identification and functional characterization of platelet-activating factor receptors in human leukocyte populations using polyclonal anti-peptide antibody. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8390683 |
Cirino G et al. | Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2470103 |
Lukiw WJ et al. | Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520467 |
Bazan NG et al. | Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8202477 |
Weissman D et al. | A platelet-activating factor antagonist, RP 55778, inhibits cytokine-dependent induction of human immunodeficiency virus expression in chronically infected promonocytic cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7681601 |
Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
Malavasi F et al. | Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3085094 |
Izquierdo I et al. | Memory enhancement by intrahippocampal, intraamygdala, or intraentorhinal infusion of platelet-activating factor measured in an inhibitory avoidance task. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7761446 |
Bazan HE et al. | Platelet-activating factor induces collagenase expression in corneal epithelial cells. | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8378347 |
Petty HR and Kindzelskii AL | Dissipative metabolic patterns respond during neutrophil transmembrane signaling. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248046 |
Liu M and Subbaiah PV | Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8016111 |
Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
Sánchez FA et al. | Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19342481 |
Xia D and Samols D | Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9122237 |
Balsinde J et al. | Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7972009 |
Levesque JP et al. | Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3018735 |
Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
Prescott SM et al. | Human endothelial cells in culture produce platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when stimulated with thrombin. | 1984 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6587368 |
Guerrant RL et al. | Role of platelet activating factor in the intestinal epithelial secretory and Chinese hamster ovary cell cytoskeletal responses to cholera toxin. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7937824 |
Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280540 |
Polonsky J et al. | Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. | 1980 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6938950 |
McIntyre TM et al. | Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3457383 |
Chignard M et al. | Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3464972 |
Billah MM and Lapetina EG | Platelet-activating factor stimulates metabolism of phosphoinositides in horse platelets: possible relationship to Ca2+ mobilization during stimulation. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6341992 |
Doebber TW and Wu MS | Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3478712 |
Johnson HM and Torres BA | Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2412225 |
Shen TY et al. | Characterization of a platelet-activating factor receptor antagonist isolated from haifenteng (Piper futokadsura): specific inhibition of in vitro and in vivo platelet-activating factor-induced effects. | 1985 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2983307 |
Stewart AG et al. | Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells. | 1990 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2158106 |
Quinn RA et al. | Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. | 2016 | Proc. Biol. Sci. | pmid:27122568 |
Aladysheva ZhI and Kaminskaia GO | [Generation of platelet activating factor by neutrophils in patients with pulmonary tuberculosis]. | 1995 | Probl Tuberk | pmid:7777455 |
Kaminskaia GO et al. | [Oxidative metabolic changes, antioxidantion, and platelet activation rat phagocytes during development of experimental specific tuberculous changes]. | 1998 | Probl Tuberk | pmid:9866402 |
Kaminskaia GO et al. | [Features of oxidative metabolism and level of platelet activating factor in pulmonary and circulating phagocytes of tuberculosis-resistant animals at stages of experimental infection]. | 1998 | Probl Tuberk | pmid:9691697 |
Kaminskaia GO et al. | [Platelet activating factor in biological fluids of animals with different species-specific resistance at the stage of infective process after inoculation with mycobacterium tuberculosis]. | 1998 | Probl Tuberk | pmid:10067355 |
Kaminskaia GO | [Platelet activating factor and its role in pulmonary pathology]. | 1994 | Probl Tuberk | pmid:8170915 |
Chanez P et al. | [Mediators and neuromediators in asthma]. | 1992 | Presse Med | pmid:1372975 |
Barbier A et al. | [Microcirculation and rheology]. | 1994 | Presse Med | pmid:8177870 |
Pirotzky E and Braquet P | [The role of the platelet-activating factor (PAF-acether) in renal pathology]. | 1988 | Presse Med | pmid:2966954 |
Denizot Y et al. | [Fecal platelet-activating factor (PAF). A marker of digestive inflammatory disorders]. | 1993 | Presse Med | pmid:8278326 |
Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
Lichterfeld A et al. | [Platelet activating factor and its possible role in bronchial asthma]. | 1988 | Prax Klin Pneumol | pmid:3041401 |