Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Dictyocaulus Infections D004022 1 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
Migraine without Aura D020326 1 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Anthrax D000881 1 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Leukostasis D018921 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Ileitis D007079 2 associated lipids
Peanut Hypersensitivity D021183 2 associated lipids
Jaundice, Obstructive D041781 2 associated lipids
Multiple Trauma D009104 2 associated lipids
Soft Tissue Injuries D017695 2 associated lipids
Amnesia, Anterograde D020324 2 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Malone B et al. Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. 1985 J. Biol. Chem. pmid:3918041
Juhan-Vague I et al. Possible participation of adenosine 5'-diphosphate, arachidonic acid and paf-acether in the platelet pro-aggregating effect of uncontrolled insulin-dependent diabetic erythrocytes in vitro. 1985 Thromb. Res. pmid:3923649
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Hayashi H et al. Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. 1985 J. Biochem. pmid:2993272
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
O'Neill C Examination of the causes of early pregnancy-associated thrombocytopenia in mice. 1985 J. Reprod. Fertil. pmid:3989801
Kertscher HP and Ostermann G [Synthesis and biological activity of isomeric structural analogs of platelet activating factor]. 1985 Pharmazie pmid:3991788
Wal F et al. PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. 1985 Thromb. Haemost. pmid:3992525
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Pirotzky E et al. A role for Paf-acether (platelet-activating factor) in acute skin inflammation? 1985 Br. J. Dermatol. pmid:4015984
Ohno M et al. An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids. 1985 Chem. Pharm. Bull. pmid:4017109
O'Neill C et al. Maternal blood platelet physiology and luteal-phase endocrinology as a means of monitoring pre- and postimplantation embryo viability following in vitro fertilization. 1985 J In Vitro Fert Embryo Transf pmid:4020241
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Weber N and Benning H Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. 1985 Eur. J. Biochem. pmid:3967662
Mallet AI and Cunningham FM Structural identification of platelet activating factor in psoriatic scale. 1985 Biochem. Biophys. Res. Commun. pmid:3970690
Suemune H et al. Synthetic studies on platelet-activating factor (PAF). 1985 Chem. Pharm. Bull. pmid:4028291
Parente L et al. The release of lyso-PAF from guinea-pig lungs. 1985 Eur. J. Pharmacol. pmid:4029263
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Wissner A et al. Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. 1985 J. Med. Chem. pmid:4032422
Wissner A et al. Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. 1985 J. Med. Chem. pmid:4032438
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Handley DA et al. Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. 1985 Thromb. Haemost. pmid:4089809
Hemker HC and Béguin S The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. 1985 Verh. K. Acad. Geneeskd. Belg. pmid:4090648
Hallam TJ et al. Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. 1985 Biochem. J. pmid:4091795
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Bergelson LD et al. Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. 1985 FEBS Lett. pmid:4043408
Kilpatrick JM and Virella G Inhibition of platelet-activating factor by rabbit C-reactive protein. 1985 Clin. Immunol. Immunopathol. pmid:4042435
Monnens L et al. Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. 1985 Clin. Nephrol. pmid:4042442
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Armstrong RA et al. Mechanism of the inhibition of platelet aggregation produced by prostaglandin F2 alpha. 1985 Prostaglandins pmid:2988022
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
Orlov SM et al. [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. 1985 Biokhimiia pmid:2408682
Braquet M et al. Leukocytic functions in burn-injured patients. 1985 Prostaglandins pmid:2989978
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017