Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| O'Flaherty JT et al. | Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. | 1981 | Am. J. Pathol. | pmid:6274199 |
| Reznichenko A and Korstanje R | The role of platelet-activating factor in mesangial pathophysiology. | 2015 | Am. J. Pathol. | pmid:25655028 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Montrucchio G et al. | Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. | 1997 | Am. J. Pathol. | pmid:9250168 |
| O'Flaherty JT et al. | 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. | 1981 | Am. J. Pathol. | pmid:7223864 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Montrucchio G et al. | Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart. | 1990 | Am. J. Pathol. | pmid:2372044 |
| Stimler NP and O'Flaherty JT | Spasmogenic properties of platelet-activating factor: evidence for a direct mechanism in the contractile response of pulmonary tissues. | 1983 | Am. J. Pathol. | pmid:6624879 |
| Warren JS | Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. | 1992 | Am. J. Pathol. | pmid:1519663 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Valone FH and Goetzl EJ | Enhancement of human polymorphonuclear leukocyte adherence by the phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC). | 1983 | Am. J. Pathol. | pmid:6624880 |
| Bussolati B et al. | PAF produced by human breast cancer cells promotes migration and proliferation of tumor cells and neo-angiogenesis. | 2000 | Am. J. Pathol. | pmid:11073830 |
| Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
| Gonzalez-Crussi F and Hsueh W | Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin. | 1983 | Am. J. Pathol. | pmid:6859226 |
| Camussi G et al. | Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. | 1983 | Am. J. Pathol. | pmid:6859232 |
| Zhou W et al. | Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. | 1993 | Am. J. Pathol. | pmid:8494049 |
| Humphrey DM | Inflammatory exudates in skin windows induced by 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine. | 1990 | Am. J. Pathol. | pmid:2407127 |
| Biancone L et al. | Motility induced by human immunodeficiency virus-1 Tat on Kaposi's sarcoma cells requires platelet-activating factor synthesis. | 1999 | Am. J. Pathol. | pmid:10550329 |
| Wild MD and Roudebush WE | Platelet-activating factor improves intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11349157 |
| Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
| Tabor BL et al. | Platelet-activating factor antagonists decrease lung protein leak in preterm ventilated rabbits. | 1992 | Am. J. Obstet. Gynecol. | pmid:1530043 |
| Narahara H and Johnston JM | Effects of endotoxins and cytokines on the secretion of platelet-activating factor-acetylhydrolase by human decidual macrophages. | 1993 | Am. J. Obstet. Gynecol. | pmid:8372856 |
| Claman P | Platelet activating factor does not improve intrauterine insemination outcome. | 2001 | Am. J. Obstet. Gynecol. | pmid:11717679 |
| Benedetto C et al. | Reduced serum inhibition of platelet-activating factor activity in preeclampsia. | 1989 | Am. J. Obstet. Gynecol. | pmid:2912073 |
| Morris C et al. | Effects of platelet-activating factor on prostaglandin E2 production by intact fetal membranes. | 1992 | Am. J. Obstet. Gynecol. | pmid:1566774 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Zhu YP et al. | The presence of platelet-activating factor binding sites in human myometrium and their role in uterine contraction. | 1992 | Am. J. Obstet. Gynecol. | pmid:1314480 |
| Rowland BL et al. | Elevated circulating concentrations of platelet activating factor in preeclampsia. | 2000 | Am. J. Obstet. Gynecol. | pmid:11035340 |
| Matorras R and Pijoan JI | The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904634 |
| Hoffman DR et al. | Detection of platelet-activating factor in amniotic fluid of complicated pregnancies. | 1990 | Am. J. Obstet. Gynecol. | pmid:2309839 |
| Thaete LG and Neerhof MG | Endothelin and platelet-activating factor: significance in the pathophysiology of ischemia/reperfusion-induced fetal growth restriction in the rat. | 2006 | Am. J. Obstet. Gynecol. | pmid:16579936 |
| Roudebush WE et al. | Platelet activating factor enhances in vitro fertilization of rabbit oocytes. | 1990 | Am. J. Obstet. Gynecol. | pmid:2240122 |
| Minhas BS et al. | Effects of platelet activating factor on mouse oocyte fertilization in vitro. | 1989 | Am. J. Obstet. Gynecol. | pmid:2603931 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Silver RK et al. | Anticardiolipin antibody-positive serum enhances endothelial cell platelet-activating factor production. | 1991 | Am. J. Obstet. Gynecol. | pmid:1750472 |
| Minhas BS | Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475981 |
| Sueoka K et al. | Platelet activating factor-induced early pregnancy factor activity from the perfused rabbit ovary and oviduct. | 1988 | Am. J. Obstet. Gynecol. | pmid:3207134 |
| Perico N and Remuzzi G | Role of platelet-activating factor in renal immune injury and proteinuria. | 1990 | Am. J. Nephrol. | pmid:2256482 |
| Kees-Folts D and Diamond JR | Relationship between hyperlipidemia, lipid mediators, and progressive glomerulosclerosis in the nephrotic syndrome. | 1993 | Am. J. Nephrol. | pmid:8116689 |
| Camussi G et al. | Platelet-activating factor in renal diseases. | 1989 | Am. J. Nephrol. | pmid:2646923 |
| Ganong BR | Roles of lipid turnover in transmembrane signal transduction. | 1991 | Am. J. Med. Sci. | pmid:1661067 |
| Muirhead EE et al. | Biologic contrasts between medullipin I and vasoactive glyceryl compounds. | 1989 | Am. J. Med. Sci. | pmid:2764021 |
| Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Barnes PJ | Inflammatory mechanisms and nocturnal asthma. | 1988 | Am. J. Med. | pmid:3041827 |
| Wasserman SI | The mast cell and theophylline in asthma. | 1985 | Am. J. Med. | pmid:3002176 |
| Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |
| Tetta C et al. | Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. | 1997 | Am. J. Kidney Dis. | pmid:9372980 |