Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Izumi T and Shimizu T | Platelet-activating factor receptor: gene expression and signal transduction. | 1995 | Biochim. Biophys. Acta | pmid:8541341 |
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| Kumar R et al. | Metabolism of platelet-activating factor (alkylacetylphosphocholine) by type-II epithelial cells and fibroblasts from rat lungs. | 1987 | Biochim. Biophys. Acta | pmid:3790610 |
| Vallee RB et al. | The role of cytoplasmic dynein in the human brain developmental disease lissencephaly. | 2000 | Biochim. Biophys. Acta | pmid:10722879 |
| Wheelan P and Clay KL | Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. | 1992 | Biochim. Biophys. Acta | pmid:1511005 |
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| Svetlov SI et al. | Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. | 1997 | Biochim. Biophys. Acta | pmid:9219895 |
| Ninio E et al. | Biosynthesis of platelet-activating factor. I. Evidence for an acetyl-transferase activity in murine macrophages. | 1982 | Biochim. Biophys. Acta | pmid:7055592 |
| Hopkins NK et al. | Evidence for mediation of acetyl glyceryl ether phosphorylcholine stimulation of adenosine 3',5'-(cyclic)monophosphate levels in human polymorphonuclear leukocytes by leukotriene B4. | 1983 | Biochim. Biophys. Acta | pmid:6313071 |
| Winkler JD et al. | Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes. | 1997 | Biochim. Biophys. Acta | pmid:9219900 |
| Clay KL et al. | Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells. | 1991 | Biochim. Biophys. Acta | pmid:1909182 |
| McCall MR et al. | Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility. | 1999 | Biochim. Biophys. Acta | pmid:9931415 |
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| Owen JS et al. | Stress-induced platelet-activating factor synthesis in human neutrophils. | 2005 | Biochim. Biophys. Acta | pmid:15863359 |
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| Subramanian VS et al. | Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: studies with platelet-activating factor-acetyl hydrolase-deficient plasma. | 1999 | Biochim. Biophys. Acta | pmid:10395969 |
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| Gora S et al. | The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. | 2006 | Biochim. Biophys. Acta | pmid:16962371 |
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| Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
| Hirafuji M et al. | Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. | 1987 | Biochim. Biophys. Acta | pmid:2888488 |
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| Touqui L et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. | 1985 | Biochim. Biophys. Acta | pmid:3967037 |
| De Plaen IG et al. | Intestinal NF-kappaB is activated, mainly as p50 homodimers, by platelet-activating factor. | 1998 | Biochim. Biophys. Acta | pmid:9630621 |
| Baker RR and Chang H | MgATP has different inhibitory effects on the use of 1-acyl-lysophosphatidylcholine and lyso platelet-activating factor acceptors by neuronal nuclear acetyltransferase activities. | 1998 | Biochim. Biophys. Acta | pmid:9630721 |
| Kishino J et al. | Synergistic effect of thromboxane A2 and N-formylmethionylleucylphenylalanine on platelet-activating factor synthesis in human polymorphonuclear neutrophils. | 1991 | Biochim. Biophys. Acta | pmid:1673352 |
| Bratton DL et al. | Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles. | 1988 | Biochim. Biophys. Acta | pmid:3401478 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
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| Alonso F et al. | A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. | 1986 | Biochim. Biophys. Acta | pmid:3092867 |
| Asmis R and Dennis EA | PAF stimulates cAMP formation in P388D1 macrophage-like cells via the formation and secretion of prostaglandin E2 in an autocrine fashion. | 1994 | Biochim. Biophys. Acta | pmid:7981245 |
| Baker RR and Chang HY | The potential for platelet-activating factor synthesis in brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex. | 1993 | Biochim. Biophys. Acta | pmid:8399340 |
| Tence M et al. | The enantiomer and the positional isomer of platelet-activating factor. | 1983 | Biochim. Biophys. Acta | pmid:6824744 |
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| Pelech SL et al. | Protein kinase C activation by platelet-activating factor is independent of enzyme translocation. | 1990 | Biochim. Biophys. Acta | pmid:2153414 |
| Bonaccorsi L et al. | Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells. | 1997 | Biochim. Biophys. Acta | pmid:9042336 |
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| Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
| Tokumura A et al. | Translocation of exogenous platelet-activating factor and its lyso-compound through plasma membranes is a rate-limiting step for their metabolic conversions into alkylacylglycerophosphocholines in rabbit platelets and guinea-pig leukocytes. | 1990 | Biochim. Biophys. Acta | pmid:2340312 |
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| Dentan C et al. | Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase. | 1996 | Biochim. Biophys. Acta | pmid:8597590 |
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| Jackson JR et al. | The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. | 1998 | Biochim. Biophys. Acta | pmid:9593866 |
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| Remy E et al. | Inhibition of platelet-activating factor biosynthesis via the acetyltransferase by arachidonic and oleic acids in ionophore A23187-stimulated bovine neutrophils. | 1989 | Biochim. Biophys. Acta | pmid:2505852 |
| Bussolino F et al. | Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. | 1987 | Biochim. Biophys. Acta | pmid:3024738 |
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| Olivier JL et al. | Influence of PAF-acether on lecithin-oriented multibilayers monitored by ESR: interaction of PAF-acether with cholesterol. | 1989 | Biochimie | pmid:2541796 |
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| Nankar SA et al. | Differential interaction of peptides derived from C-terminal domain of human apolipoprotein E with platelet activating factor analogs. | 2013 | Biochimie | pmid:23376877 |
| Yost CC et al. | The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. | 2010 | Biochimie | pmid:20167241 |
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| Kuznetsova TI and Kulikov VI | [The effect of aldehydogenic and acyl structural analogs of platelet activating factor on the formation of superoxide radicals by human blood leukocytes]. | 1992 | Biokhimiia | pmid:1327185 |
| Kulikov VI and Bergel'son LD | [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. | 1984 | Biokhimiia | pmid:6093897 |
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| Lichko LP et al. | [The effect of PAF, sphingosine and heparin on certain phosphohydrolase and transport activity of yeast vacuoles]. | 1994 | Biokhimiia | pmid:7948417 |
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| Muzia GI and Kulikov VI | [Effect of sn-2-acetylated analogs of phosphatidalic acid on release and aggregation of human platelets]. | 1996 | Biokhimiia | pmid:8724603 |
| Kulikov VI and Muzia GI | [Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators]. | 1992 | Biokhimiia | pmid:1420585 |
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| Avdonin PV and Altukhova IP | [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. | 1985 | Biokhimiia | pmid:2416359 |
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