Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Akagi M et al. | Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. | 1997 | Arzneimittelforschung | pmid:9450165 |
| Hirashima Y et al. | Platelet-activating factor and edema surrounding meningiomas. | 1998 | J. Neurosurg. | pmid:9452240 |
| Oancea E et al. | Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. | 1998 | J. Cell Biol. | pmid:9456311 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Cao Y et al. | Expression of plasma platelet-activating factor acetylhydrolase is transcriptionally regulated by mediators of inflammation. | 1998 | J. Biol. Chem. | pmid:9461591 |
| Kulikov VI and Muzya GI | Ether lipids and platelet-activating factor: evolution and cellular function. | 1997 | Biochemistry Mosc. | pmid:9461631 |
| Sibelius U et al. | Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. | 1998 | J. Exp. Med. | pmid:9463400 |
| Winkler JD et al. | Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase. | 1998 | Mol. Pharmacol. | pmid:9463491 |
| Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
| Wang HG et al. | The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. | 1998 | Shock | pmid:9466475 |
| Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
| Singh N et al. | Possible mechanism of alprazolam-induced amnesia in mice. | 1998 | Pharmacology | pmid:9467187 |
| Golubeva TS et al. | [Determination of the nucleosomal fragmentation of DNA of ACL cells during their incubation with human platelets]. | 1997 | Biull Eksp Biol Med | pmid:9471253 |
| Chupin VV et al. | On the synthesis of platelet-activating factor via acetylation of 1-alkyl-sn-glycero-3-phosphocholine. Formation of structural isomer of PAF in the presence of bases. | 1996 | Chem. Phys. Lipids | pmid:9471401 |
| Thakur A et al. | The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: homeostatic mechanisms. | 1998 | J. Clin. Immunol. | pmid:9475355 |
| Miotla JM et al. | Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9476906 |
| Jung KY et al. | Platelet activating factor antagonist activity of ginsenosides. | 1998 | Biol. Pharm. Bull. | pmid:9477174 |
| Renis M et al. | Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. | 1998 | Brain Res. | pmid:9479063 |
| Péterfy M et al. | Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. | 1998 | Genomics | pmid:9479492 |
| Antonopoulou S et al. | Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. | 1998 | Biochem. J. | pmid:9480892 |