Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arnoux B et al. | Effect of PAF-acether in non-human primates. | 1988 | Prog. Clin. Biol. Res. | pmid:2837781 |
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| Piper PJ and Yaacob HB | Interactions of platelet activating factor, thromboxane A2 and leukotrienes in guinea-pig heart. | 1989 | Prog. Clin. Biol. Res. | pmid:2508116 |
| Gasser H et al. | Effect of platelet-activating factor (PAF) administration in chronically instrumented sheep--analysis of PAF in plasma. | 1989 | Prog. Clin. Biol. Res. | pmid:2780708 |
| Bonavida B et al. | The involvement of platelet-activating factor (PAF)-induced monocyte activation and tumor necrosis factor (TNF) production in shock. | 1989 | Prog. Clin. Biol. Res. | pmid:2780710 |
| Heuer H | Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity. | 1989 | Prog. Clin. Biol. Res. | pmid:2780739 |
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| Bahr T et al. | Influence of inhibitors of the eicosanoid metabolism, and of eicosanoids- and PAF-acether antagonists on mortality and some biochemical parameters of three shock models. | 1989 | Prog. Clin. Biol. Res. | pmid:2798447 |
| Bradley LM et al. | The role of lipid mediators in hypoxic pulmonary vasoconstriction in newborns. | 1989 | Prog. Clin. Biol. Res. | pmid:2798449 |
| Mest HJ et al. | The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm. | 1989 | Prog. Clin. Biol. Res. | pmid:2798457 |
| Baker RC | Ethanol modulation of the effects of platelet-activating factor on human platelets and a macrophage cell line. | 1990 | Prog. Clin. Biol. Res. | pmid:2300602 |
| Pritze S et al. | Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro. | 1989 | Prog. Clin. Biol. Res. | pmid:2798458 |
| Dembinska-Kiec A et al. | Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. | 1989 | Prog. Clin. Biol. Res. | pmid:2798459 |
| Harper MJ et al. | Platelet-activating factor (PAF) and blastocyst-endometrial interactions. | 1989 | Prog. Clin. Biol. Res. | pmid:2542988 |
| Etienne A et al. | Possible involvement of platelet-activating factor in endotoxin-induced abortion. | 1988 | Prog. Clin. Biol. Res. | pmid:3393560 |
| McNamara PJ et al. | The interaction of alpha-1-acid glycoprotein with endogenous autocoids, in particular, platelet activating factor (PAF). | 1989 | Prog. Clin. Biol. Res. | pmid:2674967 |
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| Mencia-Hurerta JM et al. | The role of platelet-activating factor (PAF) in immune and cytotoxic processes. | 1989 | Prog. Clin. Biol. Res. | pmid:2675061 |
| Heuer H and Casals-Stenzel J | The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086. | 1989 | Prog. Clin. Biol. Res. | pmid:2675077 |
| Lefer AM | Platelet activating factor (PAF) and its role in cardiac injury. | 1989 | Prog. Clin. Biol. Res. | pmid:2678133 |
| Levin M et al. | Platelet immune complex interaction in the pathogenesis of Kawasaki disease. | 1987 | Prog. Clin. Biol. Res. | pmid:3423040 |
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| Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
| Schirmer WJ et al. | Systemic and renal hemodynamic response to platelet activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2726980 |
| Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
| Darius H and Lefer AM | Pharmacologic antagonism of platelet activating factor and peptide leukotrienes inhibits guinea pig anaphylaxis. | 1987 | Prog. Clin. Biol. Res. | pmid:3118384 |
| Ishii S and Shimizu T | Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. | 2000 | Prog. Lipid Res. | pmid:10729607 |
| Whatley RE et al. | Lipid metabolism and signal transduction in endothelial cells. | 1990 | Prog. Lipid Res. | pmid:2128404 |
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| Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
| Hikiji H et al. | The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. | 2008 | Prog. Lipid Res. | pmid:18187046 |
| Frenkel RA et al. | The biochemical role of platelet-activating factor in reproduction. | 1996 | Prog. Lipid Res. | pmid:8944225 |
| Snyder F et al. | The role of transacylases in the metabolism of arachidonate and platelet activating factor. | 1992 | Prog. Lipid Res. | pmid:1641397 |
| Tokumura A | A family of phospholipid autacoids: occurrence, metabolism and bioactions. | 1995 | Prog. Lipid Res. | pmid:7480064 |
| Lagarde M | Metabolism of fatty acids by platelets and the functions of various metabolites in mediating platelet function. | 1988 | Prog. Lipid Res. | pmid:3060881 |
| Hanahan DJ and Kumar R | Platelet activating factor; chemical and biochemical characteristics. | 1987 | Prog. Lipid Res. | pmid:3313430 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Damiani E and Ullrich SE | Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. | 2016 | Prog. Lipid Res. | pmid:27073146 |
| Grassi S and Pettorossi VE | Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices. | 2001 | Prog. Neurobiol. | pmid:11311461 |
| Maclennan KM et al. | Platelet-activating factor in the CNS. | 1996 | Prog. Neurobiol. | pmid:9015828 |
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
| McCulloch RK and Vandongen R | Mechanisms of platelet activating factor-induced aggregation and secretion in human platelets. | 1990 | Prostaglandins | pmid:2106712 |
| Sakuma Y et al. | Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice. | 1991 | Prostaglandins | pmid:1801063 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Billah MM et al. | Platelet-activating factor metabolism in human amnion and the responses of this tissue to extracellular platelet-activating factor. | 1985 | Prostaglandins | pmid:3936121 |
| Acker G et al. | Role of platelet-activating factor (PAF) in the ovoimplantation in the rat: effect of the specific PAF-acether antagonist, BN 52021. | 1988 | Prostaglandins | pmid:3129758 |
| Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
| Cucala M et al. | Central regulation of gastric acid secretion by platelet-activating factor in anesthesized rats. | 1989 | Prostaglandins | pmid:2499013 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Kuzan FB et al. | Role of spermatozoal platelet-activating factor in fertilization. | 1990 | Prostaglandins | pmid:2155438 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| Takehara S et al. | Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. | 1990 | Prostaglandins | pmid:1965554 |
| Kaminski DL et al. | Studies on the etiology of acute acalculous cholecystitis: the effect of lipopolysaccharide on human gallbladder mucosal cells. | 1994 | Prostaglandins | pmid:8041874 |
| Jancar S et al. | Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. | 1987 | Prostaglandins | pmid:3588970 |
| Malo PE et al. | Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. | 1987 | Prostaglandins | pmid:3588971 |
| Madden MC et al. | Polarized release of lipid mediators derived from phospholipase A2 activity in a human bronchial cell line. | 1994 | Prostaglandins | pmid:7809385 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Kikukawa Y et al. | The effect of platelet activating factor on ovulation. | 1991 | Prostaglandins | pmid:1775639 |
| Pons L et al. | Role of platelet-activating factor (PAF) and prostaglandins in colonic motor and secretory disturbances induced by Escherichia coli endotoxin in conscious rats. | 1994 | Prostaglandins | pmid:8016383 |
| Lee MJ et al. | Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. | 1994 | Prostaglandins | pmid:8016391 |
| Kaminski DL et al. | The production of experimental cholecystitis by endotoxin. | 1994 | Prostaglandins | pmid:8016392 |
| Ibbotson GC and Wallace JL | Beneficial effects of prostaglandin E2 in endotoxic shock are unrelated to effects on PAF-acether synthesis. | 1989 | Prostaglandins | pmid:2727308 |
| Yamanaka S et al. | 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. | 1993 | Prostaglandins | pmid:8484010 |
| Myers AK et al. | Antagonism of PAF-induced death in mice. | 1988 | Prostaglandins | pmid:3131837 |
| Levine L | Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line). | 1990 | Prostaglandins | pmid:2247616 |
| Whatley RE et al. | Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells. | 1992 | Prostaglandins | pmid:1546171 |
| Satoh K et al. | Activity of platelet-activating factor (PAF) acetylhydrolase in plasma from patients with ischemic cerebrovascular disease. | 1988 | Prostaglandins | pmid:3399678 |
| Subissi A et al. | Effects of anti-asthma drugs on PAF-induced death in mice. | 1988 | Prostaglandins | pmid:2907663 |
| Jager GV et al. | Antagonist of platelet-activating factor prevents prostaglandin E2 induced ocular hypertension in rabbits. | 1993 | Prostaglandins | pmid:8424134 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Qu X et al. | Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. | 1996 | Prostaglandins | pmid:8935185 |
| Etienne A et al. | Modulation of eosinophil recruitment in the rat by the platelet-activating factor (PAF) antagonist, BN 52021, the somatostatin analog, BIM 23014, and by cyclosporin A. | 1989 | Prostaglandins | pmid:2748916 |
| Morganroth ML et al. | Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. | 1987 | Prostaglandins | pmid:3108962 |
| Terasawa M et al. | Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor. | 1990 | Prostaglandins | pmid:2093935 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Trochtenberg DS et al. | Effects of thromboxane synthase and cyclooxygenase inhibition on PAF-induced changes in lung function and arachidonic acid metabolism. | 1992 | Prostaglandins | pmid:1475377 |
| Kim YD et al. | Constriction of canine coronary arteries by platelet activating factor after brief ischemia. | 1993 | Prostaglandins | pmid:8234834 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Myers SI et al. | Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. | 1995 | Prostaglandins | pmid:8588069 |
| Guinot P et al. | Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. | 1987 | Prostaglandins | pmid:3432562 |
| Ernst A et al. | The effect of PAF in the cochlea of guinea pigs. | 1989 | Prostaglandins | pmid:2602560 |
| Chan WP and Levy JV | Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. | 1991 | Prostaglandins | pmid:1665568 |
| Sakuma Y et al. | Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs. | 1991 | Prostaglandins | pmid:1763202 |
| Camussi G et al. | Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. | 1983 | Prostaglandins | pmid:6346397 |
| Bureau M et al. | Desensitization and antagonism of rat polymorphonuclear leukocytes stimulated with PAF acether. | 1987 | Prostaglandins | pmid:3035615 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Cordeiro RS et al. | Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. | 1986 | Prostaglandins | pmid:3103172 |
| Bonnet J et al. | Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig. | 1983 | Prostaglandins | pmid:6419289 |
| Geissler FT et al. | Lipid mediator production by post-implantation rat embryos in vitro. | 1989 | Prostaglandins | pmid:2505333 |
| Fernandes AJ et al. | Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. | 1991 | Prostaglandins | pmid:1801060 |
| White HL and Faison LD | Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. | 1988 | Prostaglandins | pmid:2903520 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |