| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Michibayashi T | Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. | 2005 | J. Atheroscler. Thromb. | pmid:16020916 |
| Owen JS et al. | An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. | 2005 | J. Lipid Res. | pmid:15520455 |
| Xie DS and Xie YT | [Role of platelet activating factor in hepatorenal syndrome]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16045031 |
| Marathe GK et al. | Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. | 2005 | J. Biol. Chem. | pmid:16115894 |
| Chang GT et al. | Purification and characterization of a new anticoagulant protein, PP27, from placenta. | 2005 | Thromb. Res. | pmid:16122555 |
| Ezoulin MJ et al. | Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. | 2005 | Neurosci. Lett. | pmid:16095823 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Choi IW et al. | TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. | 2005 | J. Allergy Clin. Immunol. | pmid:16159621 |
| Burgos RA et al. | 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. | 2005 | Planta Med. | pmid:16041644 |
| Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
| Denizot Y et al. | Platelet-activating factor and liver metastasis of colorectal cancer. | 2005 | Int. J. Cancer | pmid:15455343 |
| Shindou H et al. | Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent. | 2005 | J. Immunol. | pmid:16002720 |
| Black S et al. | An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. | 2005 | J. Immunol. | pmid:16002722 |
| Koch E | Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. | 2005 | Phytomedicine | pmid:15693702 |
| Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
| El-Medany A et al. | Attenuation of bleomycin-induced lung fibrosis in rats by mesna. | 2005 | Eur. J. Pharmacol. | pmid:15713430 |
| Ninio E | Phospholipid mediators in the vessel wall: involvement in atherosclerosis. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716789 |
| Evans L et al. | A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. | 2005 | J. Pharm. Pharmacol. | pmid:15720781 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia. | 2005 | Brain Res. Mol. Brain Res. | pmid:15661369 |
| Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Roudebush WE et al. | The significance of platelet-activating factor and fertility in the male primate: a review. | 2005 | J. Med. Primatol. | pmid:15667340 |
| Ottino P et al. | PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15671273 |
| Hidalgo MA et al. | Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. | 2005 | Br. J. Pharmacol. | pmid:15678086 |
| Oku H et al. | Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. | 2005 | Planta Med. | pmid:15678383 |
| Lin P et al. | Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. | 2005 | J. Immunol. | pmid:15728511 |
| Shimada T et al. | Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms. | 2005 | J. Endocrinol. | pmid:15684346 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Göggel R and Uhlig S | The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema. | 2005 | Eur. Respir. J. | pmid:15863642 |
| MartÃnez-Cócera C et al. | Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study. | 2005 | J Investig Allergol Clin Immunol | pmid:15864879 |
| Yeh JH et al. | 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells. | 2005 | Life Sci. | pmid:15878360 |
| Cheng L et al. | Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. | 2005 | Gastroenterology | pmid:16285965 |
| Medvedev IN and GromnatsiÄ NI | [The influence of nebivolol on thrombocyte aggregation in patients with arterial hypertension with metabolic sydrome]. | 2005 | Klin Med (Mosk) | pmid:15881638 |
| Rastelli VM et al. | Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats. | 2005 | Inflamm. Res. | pmid:15883740 |
| Ko HM et al. | Involvement of matrix metalloproteinase-9 in platelet-activating factor-induced angiogenesis. | 2005 | FEBS Lett. | pmid:15848174 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Chen LW et al. | Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. | 2005 | J. Biomed. Sci. | pmid:15917990 |
| Goldring WP et al. | Novel phomactin analogues as PAF receptor ligands. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15922596 |
| Tombul T et al. | Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. | 2005 | J Clin Neurosci | pmid:15925775 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Schram MT et al. | Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | 2005 | Hypertension | pmid:15851628 |
| Denizot Y et al. | Platelet-activating factor and human thyroid cancer. | 2005 | Eur. J. Endocrinol. | pmid:15994743 |
| Fulkerson PC et al. | CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. | 2005 | Blood | pmid:15802529 |
| Androulakis N et al. | Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation. | 2005 | J. Lipid Res. | pmid:15995176 |
| Grypioti AD et al. | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. | 2005 | Arch. Toxicol. | pmid:15995853 |
| Chatterjee BE et al. | Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. | 2005 | J. Leukoc. Biol. | pmid:16000391 |
| Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
| Souza DG and Teixeira MM | The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962100 |
| Castro Faria Neto HC et al. | Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962103 |
| White DC et al. | Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. | 2005 | J. Microbiol. Methods | pmid:15963585 |
| Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Dong J et al. | [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171322 |
| McLarnon JG et al. | Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. | 2005 | J. Neurosci. Res. | pmid:15948178 |
| Ozger S et al. | Effects of platelet-activating factor on nitrergic transmission in rabbit corpus cavernosum. | 2005 | Int. J. Urol. | pmid:15985080 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Vardar S et al. | Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2005 | J. Periodontol. | pmid:15830643 |
| Uhlig S et al. | Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. | 2005 | Pharmacol Rep | pmid:16415501 |
| Sheppard FR et al. | Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation. | 2005 | J Trauma | pmid:15824651 |
| Leveau P et al. | Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. | 2005 | Biochem. Pharmacol. | pmid:15826603 |
| Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
| Asai Y | Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. | 2005 | Pharmazie | pmid:15801673 |
| Nacken W et al. | S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15778088 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Perry SW et al. | HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. | 2005 | J. Immunol. | pmid:15778398 |
| Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
| Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
| Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
| Hudry-Clergeon H et al. | Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. | 2005 | FASEB J. | pmid:15791001 |
| Ersoy B et al. | The role of platelet-activating factor in pathogenesis of type 1 diabetes. | 2005 | Diabetes Care | pmid:15793212 |
| Grigoriou O et al. | Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | 2005 | Fertil. Steril. | pmid:15749490 |
| Cheng HH et al. | Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. | 2005 | Pharmacology | pmid:15591819 |
| Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
| Wang CP et al. | [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16409839 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
| Milias GA et al. | Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. | 2005 | Eur. J. Appl. Physiol. | pmid:16151835 |
| Hauser CJ et al. | Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16168959 |
| Kihara Y et al. | Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. | 2005 | J. Exp. Med. | pmid:16172262 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| Melo RC et al. | Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. | 2005 | Traffic | pmid:16138901 |
| Ueda Y et al. | Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. | 2005 | Biol. Pharm. Bull. | pmid:16141562 |
| Chang GT et al. | Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. | 2005 | J Ethnopharmacol | pmid:16125889 |
| Iversen VV et al. | Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. | 2005 | Acta Physiol. Scand. | pmid:16128692 |
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Ward JR et al. | Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. | 2005 | Thromb. Haemost. | pmid:16270639 |
| Walz PH et al. | Platelet function and association of bovine viral diarrhea virus with platelets of persistently infected cattle. | 2005 | Am. J. Vet. Res. | pmid:16273905 |
| Shargall Y et al. | Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatment. | 2005 | J. Heart Lung Transplant. | pmid:16210120 |
| Löhrke B et al. | Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. | 2005 | J. Mol. Endocrinol. | pmid:16326838 |
| Fragopoulou E et al. | Characterization of acetyl-CoA: lyso-PAF acetyltransferase of human mesangial cells. | 2005 | Mediators Inflamm. | pmid:16258193 |
| Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |
| Shibamoto T et al. | Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303618 |
| Vieira-de-Abreu A et al. | Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx. | 2005 | Int. Immunopharmacol. | pmid:16275631 |
| Bellizzi MJ et al. | Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. | 2005 | J. Clin. Invest. | pmid:16276420 |
| Yu P et al. | Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability. | 2005 | Microcirculation | pmid:16284005 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |
| Nakagawa K et al. | Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa. | 2004 | Fertil. Steril. | pmid:15474073 |
| Vardar S et al. | Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2004 | J. Periodontol. | pmid:15732866 |
| Lee SH et al. | Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. | 2004 | Biol. Reprod. | pmid:15151927 |