| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Heptinstall S and Bevan J | How can we inhibit 5-HT-induced platelet aggregation and why should we bother? | 1988 | Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. | pmid:2465956 |
| Smith SK and Kelly RW | Effect of platelet-activating factor on the release of PGF-2 alpha and PGE-2 by separated cells of human endometrium. | 1988 | J. Reprod. Fertil. | pmid:3422322 |
| Alessandrì MG et al. | PAF-induced histamine release in the isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:2456276 |
| Martin TR et al. | Pulmonary responses to bronchoconstrictor agonists in the mouse. | 1988 | J. Appl. Physiol. | pmid:2457008 |
| Yoshida K et al. | PAF inhibitors of microbial origin. Studies on diketopiperazine derivatives. | 1988 | Prog Biochem Pharmacol | pmid:2457219 |
| Nasmith PE and Grinstein S | Cytosolic calcium, oxygen consumption and the intracellular pH of stimulated neutrophils. | 1988 | Biosci. Rep. | pmid:2840131 |
| Anderson G and Fennessy M | Effects of REV 5901, a 5-lipoxygenase inhibitor and leukotriene antagonist, on pulmonary responses to platelet activating factor in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3145088 |
| Sessler CN et al. | Effects of platelet-activating factor antagonist SRI 63-441 on endotoxemia in sheep. | 1988 | J. Appl. Physiol. | pmid:3145934 |
| Del Monte M and Subissi A | Platelet-activating factor-induced contraction of guinea-pig lung parenchymal strips: possible involvement of arachidonate metabolites. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3149718 |
| Hofmann B et al. | Proaggregatory and inhibitory effects of 2-O-ethyl analogues of platelet-activating factor (PAF) on human and rabbit platelets. | 1988 | Thromb. Res. | pmid:3381200 |
| Rao GH | Measurement of ionized calcium in normal human blood platelets. | 1988 | Anal. Biochem. | pmid:3382012 |
| Banks JB et al. | Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol. | 1988 | Biochim. Biophys. Acta | pmid:3382692 |
| Shalit M et al. | Platelet activating factor increases expression of complement receptors on human neutrophils. | 1988 | J. Leukoc. Biol. | pmid:2842423 |
| Miyazawa K et al. | Modulation of stimulus-dependent human platelet activation by C-reactive protein modified with active oxygen species. | 1988 | J. Immunol. | pmid:3385211 |
| Archer CB et al. | Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. | 1988 | J. Invest. Dermatol. | pmid:3385217 |
| Rosenthal MD et al. | Esterification of 8,11,14-eicosatrienoate and arachidonate into alkylacyl- and diacylglycerophosphocholine by vascular endothelial cells. | 1988 | Lipids | pmid:3148797 |
| Sato N et al. | Microvascular basis of gastric mucosal protection. | 1988 | J. Clin. Gastroenterol. | pmid:3183337 |
| Goodwin JS and Behrens T | Role of lipoxygenase metabolites of arachidonic acid in T cell activation. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837956 |
| Abraham WM | The role of leukotrienes in allergen-induced late responses in allergic sheep. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837960 |
| Mazière JC et al. | PAF-acether decreases low density lipoprotein degradation and alters lipid metabolism in cultured human fibroblasts. | 1988 | FEBS Lett. | pmid:3402608 |
| Hellegouarch A et al. | Effects of BN 52063 and other agents inhibiting platelet-activating factor-induced contractile responses in rat portal vein. | 1988 | J. Pharm. Pharmacol. | pmid:2907020 |
| Subissi A et al. | Effects of anti-asthma drugs on PAF-induced death in mice. | 1988 | Prostaglandins | pmid:2907663 |
| Lima MC et al. | Mediators of inflammation and antagonism of experimental pleurisy in the rat by fenspiride. | 1988 | Rhinol. Suppl. | pmid:2907679 |
| Smith LJ et al. | Mechanism of platelet activating factor-induced bronchoconstriction in humans. | 1988 | Am. Rev. Respir. Dis. | pmid:3195800 |
| O'Neill C et al. | Embryo-derived platelet-activating factor. Its diagnostic and therapeutic future. | 1988 | Ann. N. Y. Acad. Sci. | pmid:3195924 |
| Ninio E et al. | Biosynthesis of paf-acether. XI. Regulation of acetyltransferase by enzyme-substrate imbalance. | 1988 | Biochim. Biophys. Acta | pmid:3196734 |
| Hsueh W and Gonzalez-Crussi F | Ischemic bowel necrosis induced by platelet-activating factor: an experimental model. | 1988 | Methods Achiev Exp Pathol | pmid:3045496 |
| Kumar R et al. | Production and effects of platelet-activating factor in the rat brain. | 1988 | Biochim. Biophys. Acta | pmid:3196741 |
| Braquet P et al. | Effects of the specific platelet-activating factor antagonists, BN 52021 and BN 52063, on various experimental gastrointestinal ulcerations. | 1988 | Eur. J. Pharmacol. | pmid:3046952 |
| Bette-Bobillo P and Bienvenue A | Platelet-activating-factor-induced serum-albumin release from rabbit platelets in the absence of calcium. | 1988 | Eur. J. Biochem. | pmid:3197724 |
| Barr R et al. | The effect of platelet activating factor on electron transport of spinach chloroplasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3048258 |
| Camussi G et al. | Synthesis and release of platelet-activating factor is inhibited by plasma alpha 1-proteinase inhibitor or alpha 1-antichymotrypsin and is stimulated by proteinases. | 1988 | J. Exp. Med. | pmid:3049910 |
| Fukuoka T et al. | [Effect of a platelet activating factor (PAF) antagonist on the hepatic afferent vascular occlusion]. | 1988 | Nihon Geka Gakkai Zasshi | pmid:3412312 |
| Janero DR et al. | Specific binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the intact canine platelet. | 1988 | Thromb. Res. | pmid:3413730 |
| Altman R et al. | Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation. | 1988 | Clin. Pharmacol. Ther. | pmid:3416553 |
| Chu KM et al. | Local vasodilator effect of platelet activating factor in the gastric, mesenteric and femoral arteries of the dog. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3418522 |
| Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
| Kochanek PM et al. | Cerebrovascular and cerebrometabolic effects of intracarotid infused platelet-activating factor in rats. | 1988 | J. Cereb. Blood Flow Metab. | pmid:3392115 |
| Michel L et al. | Biosynthesis of paf-acether factor-acether by human skin fibroblasts in vitro. | 1988 | J. Immunol. | pmid:3397536 |
| Morrison WJ and Shukla SD | Desensitization of receptor-coupled activation of phosphoinositide-specific phospholipase C in platelets: evidence for distinct mechanisms for platelet-activating factor and thrombin. | 1988 | Mol. Pharmacol. | pmid:2827000 |
| Steel LK et al. | Quantitative, functional and biochemical alterations in the peritoneal cells of mice exposed to whole-body gamma-irradiation. I. Changes in cellular protein, adherence properties and enzymatic activities associated with platelet-activating factor formation and inactivation, and arachidonate metabolism. | 1988 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:3286551 |
| Barnes PJ et al. | Platelet-activating factor as a mediator of allergic disease. | 1988 | J. Allergy Clin. Immunol. | pmid:3286723 |
| Nakayama R and Saito K | [PAF and its physiological significance in normal tissue]. | 1988 | Seikagaku | pmid:3286791 |
| Dulioust A et al. | Immunoregulatory functions of paf-acether (platelet-activating factor). | 1988 | Prog. Clin. Biol. Res. | pmid:3071809 |
| Chung KF et al. | Ketotifen inhibits the cutaneous but not the airway responses to platelet-activating factor in man. | 1988 | J. Allergy Clin. Immunol. | pmid:3288683 |
| Romero A et al. | [Effect of corticosteroids, quinacrine and L-652, 731 on experimental aggregation of polymorphonuclear leukocytes induced by complement and platelet activating factor (PAF)]. | 1988 | Rev. Esp. Fisiol. | pmid:3072620 |
| Page CP and Robertson DN | The role of PAF in altered airway responsiveness. | 1988 | Prog. Clin. Biol. Res. | pmid:3289016 |
| Braquet P et al. | Platelet activating factor as a mediator in cerebral ischemia and related disorders. | 1988 | Biomed. Biochim. Acta | pmid:3073761 |
| Esplugues JV and Whittle BJ | Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat. | 1988 | Br. J. Pharmacol. | pmid:3349230 |
| Kobayashi T et al. | Metabolism and disposition of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate (MOTP) in rats and dogs. | 1988 | Xenobiotica | pmid:3354232 |
| Arnoux B et al. | Accumulation of platelets and eosinophils in baboon lung after paf-acether challenge. Inhibition by ketotifen. | 1988 | Am. Rev. Respir. Dis. | pmid:3354991 |
| Kosano H and Takatani O | Reduction of epidermal growth factor binding in human breast cancer cell lines by an alkyl-lysophospholipid. | 1988 | Cancer Res. | pmid:3262419 |
| Berstad A et al. | Effect of platelet-activating factor and its receptor antagonist, SRI 63-675, on gastric bleeding in rats. | 1988 | Scand. J. Gastroenterol. | pmid:3262915 |
| Morley J et al. | Pharmacological evaluation of prophylactic anti-asthma drugs by reference to the pathological sequelae of exposure to allergen or platelet activating factor. | 1988 | Agents Actions Suppl. | pmid:3262989 |
| Subissi A and Criscuoli M | Effects of LG 30435 on different platelet activating factor-induced responses. | 1988 | Agents Actions Suppl. | pmid:3262990 |
| Heuer H and Casals-Stenzel J | Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge. | 1988 | Agents Actions Suppl. | pmid:3262991 |
| Piper PJ et al. | Release of leukotrienes from porcine and human blood vessels by immunological and nonimmunological stimuli. | 1988 | Ann. N. Y. Acad. Sci. | pmid:2837950 |
| Haynes J et al. | Platelet-activating factor antagonists increase vascular reactivity in perfused rat lungs. | 1988 | J. Appl. Physiol. | pmid:3209541 |
| Ryan US et al. | Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells. | 1988 | J. Appl. Physiol. | pmid:3209566 |
| Nogami M et al. | [Effects of a platelet activating factor (PAF) antagonist CV-3988 on acute gastric erosions in rats by water immersion and restrained stress, and by ethanol]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3210345 |
| Schwertschlag US et al. | Nonimmunological alterations of glomerular filtration by s-PAF in the rat kidney. | 1988 | Kidney Int. | pmid:3210538 |
| Fisher RA et al. | AGEPC: a potent calcium-dependent chemical mediator in the liver. | 1988 | Adv. Exp. Med. Biol. | pmid:3213685 |
| Rubin RM et al. | Prostaglandin-independent inhibition of ocular vascular permeability by a platelet-activating factor antagonist. | 1988 | Arch. Ophthalmol. | pmid:3261165 |
| van Delft JL et al. | Specific receptor sites for PAF in iris and ciliary body of the rabbit eye. | 1988 | Curr. Eye Res. | pmid:2854038 |
| Shirinsky VP et al. | Agonist-induced polyphosphoinositide breakdown in cultured human endothelial and vascular smooth muscle cells. | 1988 | Health Psychol | pmid:2854052 |
| Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |
| Martin J | Platelet-activating factor. | 1988 Dec 24-31 | Lancet | pmid:2904593 |
| Gebhardt BM et al. | Modulation of in vitro immune reactions by platelet activating factor and a platelet activating factor antagonist. | 1988 Jan-Feb | Immunopharmacology | pmid:2966135 |
| Santos OF et al. | [Platelet activating factor in nephrology: physiopathologic and therapeutic perspectives]. | 1988 Jul-Aug | Rev Paul Med | pmid:3076976 |
| Lakin KM et al. | [Effect of analogs and antagonists of the thrombocyte-activating factor (PAF) on blood platelet aggregation]. | 1988 Jul-Aug | Farmakol Toksikol | pmid:2847936 |
| Whatley RE et al. | Endothelium from diverse vascular sources synthesizes platelet-activating factor. | 1988 May-Jun | Arteriosclerosis | pmid:3130833 |
| Di Marzo V et al. | Neuropeptides and leukotriene biosynthesis: the effect of calcitonin, peptide histidine valine-42, helodermin, neuropeptide Y and galanin. | 1988 May-Jun | Neuropeptides | pmid:2458537 |
| Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
| Labrakis-Lazanas K et al. | PAF of biological fluids in disease: blood levels in allergic rhinitis. | 1988 Sep-Oct | Haematologica | pmid:3143636 |
| Cluzel M et al. | Release of platelet-activating factor and the metabolism of leukotriene B4 by the human neutrophil when studied in a cell superfusion model. | 1989 | J. Immunol. | pmid:2555414 |
| Fradin A et al. | Platelet-activating factor and leukotriene biosynthesis in whole blood. A model for the study of transcellular arachidonate metabolism. | 1989 | J. Immunol. | pmid:2555415 |
| Agwu DE et al. | Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2466463 |
| Dent G et al. | [3H]WEB 2086 labels platelet activating factor receptors in guinea pig and human lung. | 1989 | Eur. J. Pharmacol. | pmid:2553451 |
| Chao W et al. | Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187. | 1989 | Biochem. J. | pmid:2494988 |
| Stengel PW and Silbaugh SA | Reversal of A23187-induced airway constriction in the guinea pig. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2495351 |
| Etienne A et al. | Protective effect of the PAF-antagonist BN 52021 on several models of gastro-intestinal mucosal damage in rats. | 1989 | Int J Tissue React | pmid:2693389 |
| Schlondorff D | Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. | 1989 | Adv. Exp. Med. Biol. | pmid:2696352 |
| Mest HJ et al. | The relevance of eicosanoids including PAF for the biochemical regulation of cardiac rhythm. | 1989 | Prog. Clin. Biol. Res. | pmid:2798457 |
| Pritze S et al. | Effect of platelet-activating factor (PAF) on porcine pulmonary vessels in vitro. | 1989 | Prog. Clin. Biol. Res. | pmid:2798458 |
| Grigorian GY et al. | Regulation of phosphoinositide turnover in endothelium from human pulmonary artery, aorta and umbilical vein. Antagonistic action on the beta-adrenoceptor coupled adenylate cyclase system. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543821 |
| Avdonin PV et al. | Selective inactivation by endogenous protein kinase C of human platelet high-affinity GTPase coupled with PAF receptors. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543823 |
| Koenderman L et al. | Dual mechanisms in priming of the chemoattractant-induced respiratory burst in human granulocytes. A Ca2+-dependent and a Ca2+-independent route. | 1989 | J. Immunol. | pmid:2911014 |
| Braquet P et al. | Role of cytokines and platelet-activating factor in microvascular immune injury. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2651321 |
| Lee TH | Pharmacological modulation of leukotriene and platelet activating factor biosynthesis and activities by alternative dietary fatty acids. | 1989 | Clin. Exp. Allergy | pmid:2653575 |
| Tao W et al. | Arachidonic acid release in rabbit neutrophils. | 1989 | Biochem. J. | pmid:2494986 |
| Leonelli FM et al. | Plasma levels of the lyso-derivative of platelet-activating factor in acute severe systemic illness. | 1989 | Clin. Sci. | pmid:2582728 |
| Viossat I et al. | Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2622972 |
| Rylander R | Role of endotoxin and glucan for the development of granulomatous disease in the lung. | 1989 | Sarcoidosis | pmid:2623374 |
| Prakash C et al. | Synthesis of trideuterated O-alkyl platelet activating factor and lyso derivatives. | 1989 | Lipids | pmid:2586235 |
| Tou JS | Platelet-activating factor regulates phospholipid metabolism in human neutrophils. | 1989 | Lipids | pmid:2586238 |
| Chang SW et al. | Tumor necrosis factor-induced lung injury is not mediated by platelet-activating factor. | 1989 | Am. J. Physiol. | pmid:2801951 |
| Mózes T et al. | Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. | 1989 | Am. J. Physiol. | pmid:2802004 |
| Sturm MJ et al. | Whole blood aggregation and plasma lyso-PAF related to smoking and atherosclerosis. | 1989 | Clin. Exp. Pharmacol. Physiol. | pmid:2805433 |
| Lukaszyk A et al. | Does acute experimental pancreatitis affect blood platelet function? | 1989 | Thromb. Res. | pmid:2524119 |
| Steinhelper ME et al. | Beta 2-adrenergic agonist regulation of immune aggregate- and platelet-activating factor-stimulated hepatic metabolism. | 1989 | J. Biol. Chem. | pmid:2544577 |