Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Maziere C et al. 1 Acyl-2 acetyl-sn-glycero-3 phosphocholine decreases the susceptibility of low-density lipoprotein to oxidative modification by copper ions, monocytes or endothelial cells. 1994 Biochim. Biophys. Acta pmid:8280775
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Roy Baker R and Chang Hy MgATP may depress de novo neuronal nuclear PAF generation by promoting the formation of alkylacylglycerophosphate, an inhibitor of alkylglycerophosphate acetyltransferase. 2002 Biochim. Biophys. Acta pmid:12457714
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Ninio E et al. Biosynthesis of platelet-activating factor (PAF-acether). V. Enhancement of acetyltransferase activity in murine peritoneal cells by calcium ionophore A23187. 1983 Biochim. Biophys. Acta pmid:6405792
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Wheelan P and Clay KL Albumin and fatty acid effects on the stimulated production of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) by human polymorphonuclear leukocytes. 1992 Biochim. Biophys. Acta pmid:1511005
Goldman R et al. Calcium-dependent PAF-stimulated generation of reactive oxygen species in a human keratinocyte cell line. 1999 Biochim. Biophys. Acta pmid:10366777
Snyder F CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. 1997 Biochim. Biophys. Acta pmid:9370322
Dumas E et al. Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor. 2012 Biochim. Biophys. Acta pmid:22198097
Snyder F The ether lipid trail: a historical perspective. 1999 Biochim. Biophys. Acta pmid:9989259
Svetlov SI et al. Regulation of platelet-activating factor (PAF) biosynthesis via coenzyme A-independent transacylase in the macrophage cell line IC-21 stimulated with lipopolysaccharide. 1997 Biochim. Biophys. Acta pmid:9219895
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Winkler JD et al. Evidence that 85 kDa phospholipase A2 is not linked to CoA-independent transacylase-mediated production of platelet-activating factor in human monocytes. 1997 Biochim. Biophys. Acta pmid:9219900
Clay KL et al. Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells. 1991 Biochim. Biophys. Acta pmid:1909182
Renooij W and Snyder F Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues. 1981 Biochim. Biophys. Acta pmid:6260215
Owen JS et al. Stress-induced platelet-activating factor synthesis in human neutrophils. 2005 Biochim. Biophys. Acta pmid:15863359
Triggiani M and Chilton FH Influence of immunologic activation and cellular fatty acid levels on the catabolism of platelet-activating factor within the murine mast cell (PT-18). 1989 Biochim. Biophys. Acta pmid:2572273
Careaga-Houck M and Sprecher H Effects of a fish oil diet on the metabolism of endogenous (n-6) and (n-3) fatty acids in rat neutrophils. 1990 Biochim. Biophys. Acta pmid:2174263
Ferrell JE et al. Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. 1988 Biochim. Biophys. Acta pmid:3355815
Blache D and Ciavatti M Rat platelet arachidonate metabolism in the presence of Ca2+, Sr2+ and Ba2+: studies using intact platelets and semi-purified phospholipase A2. 1987 Biochim. Biophys. Acta pmid:2444263
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Sturk A et al. Synthesis of platelet-activating factor by human blood platelets and leucocytes. Evidence against selective utilization of cellular ether-linked phospholipids. 1989 Biochim. Biophys. Acta pmid:2512985
Kloprogge E et al. Stimulus-aggregation coupling in platelets activated with PAF-acether. 1986 Biochim. Biophys. Acta pmid:3089297
Nishihira J et al. A role for oxygen radicals in rat monocytic leukemia cell differentiation under stimulation with platelet-activating factor. 1994 Biochim. Biophys. Acta pmid:8305501
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
Lauener RW et al. A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. 1999 Biochim. Biophys. Acta pmid:10559473
Leyravaud S and Benveniste J Regulation of cellular retention of paf-acether by extracellular pH and cell concentration. 1989 Biochim. Biophys. Acta pmid:2775773
Rosenthal MD et al. 1,3-Dioctanoylglycerol modulates arachidonate mobilization in human neutrophils and its inhibition by PGBx: evidence of a protein-kinase-C-independent role for diacylglycerols in signal transduction. 1993 Biochim. Biophys. Acta pmid:8387343
Gora S et al. The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. 2006 Biochim. Biophys. Acta pmid:16962371
Fauler J et al. Platelet-activating factor induces the production of leukotrienes by human monocytes. 1989 Biochim. Biophys. Acta pmid:2790041
Bauldry SA and Wooten RE Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. 1996 Biochim. Biophys. Acta pmid:8816854
Bratton DL et al. Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. 1988 Biochim. Biophys. Acta pmid:3370214
Wang J et al. The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. 1988 Biochim. Biophys. Acta pmid:3370222
Clark PO et al. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. 1980 Biochim. Biophys. Acta pmid:7357030
Hirafuji M et al. Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. 1987 Biochim. Biophys. Acta pmid:2888488
Tan X et al. PAF and TNF increase the precursor of NF-kappa B p50 mRNA in mouse intestine: quantitative analysis by competitive PCR. 1994 Biochim. Biophys. Acta pmid:7947998
Samples BL et al. Subcellular localization of enzyme activities involved in the metabolism of platelet-activating factor in rainbow trout leukocytes. 1999 Biochim. Biophys. Acta pmid:10101269
Okayasu T et al. Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. 1986 Biochim. Biophys. Acta pmid:3947669
Siafaka-Kapadai A and Hanahan D An endogenous inhibitor of PAF-induced platelet aggregation, isolated from rat liver, has been identified as free fatty acid. 1993 Biochim. Biophys. Acta pmid:8382959
Sawyer DB and Andersen OS Platelet-activating factor is a general membrane perturbant. 1989 Biochim. Biophys. Acta pmid:2480815
Bette-Bobillo P et al. Interaction between blood components and a spin-labeled analogue of PAF-acether. 1986 Biochim. Biophys. Acta pmid:3017416
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Kishino J et al. Synergistic effect of thromboxane A2 and N-formylmethionylleucylphenylalanine on platelet-activating factor synthesis in human polymorphonuclear neutrophils. 1991 Biochim. Biophys. Acta pmid:1673352
Bratt T et al. Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands. 1999 Biochim. Biophys. Acta pmid:10572948
Bratton DL et al. Effects of platelet activating factor on calcium-lipid interactions and lateral phase separations in phospholipid vesicles. 1988 Biochim. Biophys. Acta pmid:3401478
Flasiński M et al. Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. 2013 Biochim. Biophys. Acta pmid:23906729
Bachelet M et al. Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. 1986 Biochim. Biophys. Acta pmid:3092866
Montero M et al. Comparative effects of cytochrome P-450 inhibitors on Ca2+ and Mn2+ entry induced by agonists or by emptying the Ca2+ stores of human neutrophils. 1993 Biochim. Biophys. Acta pmid:7684611
Alonso F et al. A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine. 1986 Biochim. Biophys. Acta pmid:3092867
Asmis R and Dennis EA PAF stimulates cAMP formation in P388D1 macrophage-like cells via the formation and secretion of prostaglandin E2 in an autocrine fashion. 1994 Biochim. Biophys. Acta pmid:7981245
Nakayama R et al. Evidence for production of platelet-activating factor by yeast Saccharomyces cerevisiae cells. 1994 Biochim. Biophys. Acta pmid:8123662
Baker RR and Chang HY The potential for platelet-activating factor synthesis in brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex. 1993 Biochim. Biophys. Acta pmid:8399340
Tence M et al. The enantiomer and the positional isomer of platelet-activating factor. 1983 Biochim. Biophys. Acta pmid:6824744
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Bratton DL et al. A model for the extracellular release of PAF: the influence of plasma membrane phospholipid asymmetry. 1991 Biochim. Biophys. Acta pmid:1705442
Caplan MS et al. Hypoxia increases stimulus-induced PAF production and release from human umbilical vein endothelial cells. 1992 Biochim. Biophys. Acta pmid:1420292
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Karpouza AP and Vakirtzi-Lemonias C The platelet-activating factor acetylhydrolase of mouse platelets. 1997 Biochim. Biophys. Acta pmid:9030208
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Tokumura A et al. Translocation of exogenous platelet-activating factor and its lyso-compound through plasma membranes is a rate-limiting step for their metabolic conversions into alkylacylglycerophosphocholines in rabbit platelets and guinea-pig leukocytes. 1990 Biochim. Biophys. Acta pmid:2340312
Herrmann DB et al. Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. 1986 Biochim. Biophys. Acta pmid:3947667
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Dentan C et al. Pefabloc, 4-[2-aminoethyl]benzenesulfonyl fluoride, is a new, potent nontoxic and irreversible inhibitor of PAF-degrading acetylhydrolase. 1996 Biochim. Biophys. Acta pmid:8597590
Karabina SA and Ninio E Plasma PAF-acetylhydrolase: an unfulfilled promise? 2006 Biochim. Biophys. Acta pmid:16807087
Gandhi CR et al. Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. 1992 Biochim. Biophys. Acta pmid:1322709
Dewald B and Baggiolini M Platelet-activating factor as a stimulus of exocytosis in human neutrophils. 1986 Biochim. Biophys. Acta pmid:3017443
Turner MR and Lumb RH Synthesis of platelet activating factor by tissues from the rainbow trout, Salmo gairdneri. 1989 Biochim. Biophys. Acta pmid:2742873
Kitagawa S et al. Inhibitory effects of phenol derivatives on bovine platelet aggregation and their effects on Ca2+ mobilization. 1989 Biochim. Biophys. Acta pmid:2493810
Lumb RH et al. Spontaneous and protein-catalyzed transfer of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) between phospholipid bilayers. 1983 Biochim. Biophys. Acta pmid:6860678
Leslie CC et al. Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. 1988 Biochim. Biophys. Acta pmid:3143418
Egger M et al. Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. 1988 Biochim. Biophys. Acta pmid:3143424
Cabré F et al. Differential hydrolysis of 1-alkyl-2-acyl and diacylglycerophosphocholines by human and non-human phospholipases A2. 1992 Biochim. Biophys. Acta pmid:1576169
Ko FN et al. CIS-19, a novel platelet activating factor receptor antagonist: in vitro and in vivo studies. 1993 Biochim. Biophys. Acta pmid:8380343
Lee YP et al. Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation. 1997 Biochim. Biophys. Acta pmid:9059515
Heymans F et al. New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures. 1981 Biochim. Biophys. Acta pmid:7306563
Jackson JR et al. The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. 1998 Biochim. Biophys. Acta pmid:9593866
Amirkhanian JD and Taeusch HW Reversible and irreversible inactivation of preformed pulmonary surfactant surface films by changes in subphase constituents. 1993 Biochim. Biophys. Acta pmid:8418890
Sumita C et al. Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. 2004 Biochim. Biophys. Acta pmid:15279882
Kawaguchi H and Yasuda H Effect of platelet-activating factor on arachidonic acid metabolism in renal epithelial cells. 1986 Biochim. Biophys. Acta pmid:3081036
Bauldry SA et al. Differential actions of diacyl- and alkylacylglycerols in priming phospholipase A2, 5-lipoxygenase and acetyltransferase activation in human neutrophils. 1991 Biochim. Biophys. Acta pmid:1854803
Hoffman DR et al. Metabolism and function of platelet-activating factor in fetal rabbit lung development. 1986 Biochim. Biophys. Acta pmid:3768390
Roy Baker R and Chang H Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors. 1998 Biochim. Biophys. Acta pmid:9507140
Kester M et al. Alkylacetylglycerophosphocholine stimulates Na+-Ca2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles. 1986 Biochim. Biophys. Acta pmid:3019423
Fradin A et al. Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. 1988 Biochim. Biophys. Acta pmid:2848583
Krishnamurthi S et al. Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA. 1987 Biochim. Biophys. Acta pmid:3101746
Gay JC and Murray JJ Differential effects of propranolol on responses to receptor-dependent and receptor-independent stimuli in human neutrophils. 1991 Biochim. Biophys. Acta pmid:1659906
Remy E et al. Inhibition of platelet-activating factor biosynthesis via the acetyltransferase by arachidonic and oleic acids in ionophore A23187-stimulated bovine neutrophils. 1989 Biochim. Biophys. Acta pmid:2505852
Svetlov S and Nigam S Calphostin C, a specific protein kinase C inhibitor, activates human neutrophils: effect on phospholipase A2 and aggregation. 1993 Biochim. Biophys. Acta pmid:7683494
Bussolino F et al. Studies on the mechanism of interleukin 1 stimulation of platelet activating factor synthesis in human endothelial cells in culture. 1987 Biochim. Biophys. Acta pmid:3024738
Tanaka T et al. Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2-polyunsaturated fatty acyl group. 1994 Biochim. Biophys. Acta pmid:8280771