| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Noguchi K et al. | The detection of platelet-activating factor in inflamed human gingival tissue. | 1989 | Arch. Oral Biol. | pmid:2783040 |
| Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
| Inoue T and Kannan MS | Platelet-activating factor-induced functional changes in the guinea pig trachea in vitro. | 1989 | Respir Physiol | pmid:2781159 |
| Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
| Cirino G et al. | Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2470103 |
| Bregestovski PD and Ryan US | Voltage-gated and receptor-mediated ionic currents in the membrane of endothelial cells. | 1989 | J. Mol. Cell. Cardiol. | pmid:2471836 |
| Morimoto H et al. | Plasma extravasation by chemical mediators in rat skin and trachea: a role of neurogenic agents on tracheal edema formation. | 1989 | Jpn. J. Pharmacol. | pmid:2473234 |
| Baydoun AR et al. | Effects of endothelin-1 on the rat isolated heart. | 1989 | J. Cardiovasc. Pharmacol. | pmid:2473308 |
| Mencia-Huerta JM et al. | Acute and long-term pulmonary effects of platelet-activating factor. | 1989 | Clin. Exp. Allergy | pmid:2473829 |
| Dray F et al. | Prostaglandin E2, leukotriene C4, and platelet-activating factor receptor sites in the brain. Binding parameters and pharmacological studies. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2549827 |
| Hosford D et al. | Platelet-activating factor and cytokine interactions in shock. | 1989 | Resuscitation | pmid:2555874 |
| Yoshida N et al. | Pathogenesis of platelet-activating factor-induced gastric mucosal damage in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2556790 |
| Block LH et al. | Platelet-activating factor (PAF)-dependent biochemical, morphologic, and physiologic responses of human platelets: demonstration of translocation of protein kinase C associated with protein phosphorylation. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2624764 |
| Murphy S and Welk G | Arachidonic acid evokes inositol phospholipid hydrolysis in astrocytes. | 1989 | FEBS Lett. | pmid:2509246 |
| Griswold DE et al. | Absence of a lyso-PAF relationship with PAF (platelet activating factor) in monosodium urate crystal-induced inflammatory exudates. | 1989 | Eicosanoids | pmid:2629894 |
| Spangenberg P et al. | Blood platelet behaviour in patients with a type I diabetes mellitus. | 1989 | Exp. Clin. Endocrinol. | pmid:2630313 |
| Medeiros YS and Calixto JB | Effect of PAF-acether on the reactivity of the isolated rat myometrium. | 1989 | Braz. J. Med. Biol. Res. | pmid:2636008 |
| Jancar S et al. | Paf-induced release of spasmogens from guinea-pig lungs. | 1989 | Br. J. Pharmacol. | pmid:2538179 |
| Kajiyama Y et al. | Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2505676 |
| Record M et al. | Subcellular localization of phospholipids and enzymes involved in PAF-acether metabolism. | 1989 | J. Cell. Biochem. | pmid:2506197 |
| Ryan JP et al. | Platelet activating factor (PAF) production by mouse embryos in vitro and its effect on embryonic metabolism. | 1989 | J. Cell. Biochem. | pmid:2506198 |
| Boughton-Smith NK et al. | Relationship between PAF-acether and thromboxane A2 biosynthesis in endotoxin-induced intestinal damage in the rat. | 1989 | Prostaglandins | pmid:2506613 |
| Violi F et al. | Inhibition of cyclooxygenase-independent platelet aggregation by sodium salicylate. | 1989 | Thromb. Res. | pmid:2506658 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| Brunelleschi S et al. | Interference of WEB 2086 and BN 52021 with Paf-induced effects on guinea-pig trachea. | 1989 | Br. J. Pharmacol. | pmid:2758225 |
| Sirén AL and Feuerstein G | Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats. | 1989 | Am. J. Physiol. | pmid:2546449 |
| Barzaghi G and Mong S | Platelet activating factor-amidophosphonate (PAF-AP), a partial agonist inhibited platelet activating factor-induced calcium mobilization in human monocytic leukemic U-937 cell. | 1989 | Life Sci. | pmid:2536882 |
| Snyder F | Biochemistry of platelet-activating factor: a unique class of biologically active phospholipids. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2536942 |
| McColl SR et al. | Involvement of guanine nucleotide binding proteins in neutrophil activation and priming by GM-CSF. | 1989 | Blood | pmid:2537115 |
| Barzaghi G et al. | Platelet-activating factor-induced phosphoinositide metabolism in differentiated U-937 cells in culture. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2537401 |
| Okubo K et al. | The existence of a platelet-activating factor (Paf-acether)-like substance in blister fluid derived from patients with bullous pemphigoid as demonstrated by human platelet aggregation techniques. | 1989 | Kurume Med J | pmid:2700767 |
| Dent G et al. | Characterization of PAF receptors on human neutrophils using the specific antagonist, WEB 2086. Correlation between receptor binding and function. | 1989 | FEBS Lett. | pmid:2537761 |
| Johnson RA et al. | An asymmetric synthesis of (R) and (S)-1-alkoxy-2,3-propanediols including precursors to platelet activating factor. | 1989 | Chem. Phys. Lipids | pmid:2766428 |
| Redkar-Brown DG and Aharony D | Inhibition of antigen-induced contraction of guinea pig trachea by ICI 198,615. | 1989 | Eur. J. Pharmacol. | pmid:2767127 |
| Koenderman L and Bruijnzeel PL | Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals. | 1989 | Immunology | pmid:2767711 |
| Pitton C et al. | Presence of PAF-acether in human breast carcinoma: relation to axillary lymph node metastasis. | 1989 | J. Natl. Cancer Inst. | pmid:2769781 |
| Tolins JP et al. | Role of platelet activating factor in endotoxemic acute renal failure in the male rat. | 1989 | J. Lab. Clin. Med. | pmid:2538527 |
| Burch RM and Tiffany CW | Tumor necrosis factor causes amplification of arachidonic acid metabolism in response to interleukin 1, bradykinin, and other agonists. | 1989 | J. Cell. Physiol. | pmid:2550484 |
| Pretolani M et al. | Role of lipoxygenase metabolites for the hyper-responsiveness to platelet-activating factor of lungs from actively sensitized guinea pigs. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2464060 |
| Goswami SK et al. | Platelet-activating factor stimulates secretion of respiratory glycoconjugate from human airways in culture. | 1989 | J. Allergy Clin. Immunol. | pmid:2478607 |
| Harper MJ et al. | Spermicidal effect of antagonists of platelet-activating factor. | 1989 | Fertil. Steril. | pmid:2707465 |
| Burstein SH et al. | Antagonism to the actions of platelet activating factor by a nonpsychoactive cannabinoid. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553925 |
| Sawyer DB and Andersen OS | Platelet-activating factor is a general membrane perturbant. | 1989 | Biochim. Biophys. Acta | pmid:2480815 |
| Mencia-Huerta JM et al. | Effect of long-term administration of platelet-activating factor on pulmonary responsiveness and morphology in the guinea pig. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2707878 |
| Bonavida B et al. | Effect of platelet-activating factor on monocyte activation and production of tumor necrosis factor. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2707879 |
| Dorsch W et al. | Antiasthmatic effects of onions. Prevention of platelet-activating factor induced bronchial hyperreactivity to histamine in guinea pigs by diphenylthiosulfinate. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2707885 |
| Murphy TM et al. | PAF-induced contraction of canine trachea mediated by 5-hydroxytryptamine in vivo. | 1989 | J. Appl. Physiol. | pmid:2708195 |
| Salem P et al. | Presence of paf-acether in human thymus. | 1989 | FEBS Lett. | pmid:2806565 |
| Ricker DD et al. | The effects of platelet-activating factor on the motility of human spermatozoa. | 1989 | Fertil. Steril. | pmid:2806605 |
| Guinot P et al. | Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. | 1989 | Haemostasis | pmid:2807039 |
| Weichert W and Breddin HK | A PAF-acether antagonist (N 48740 RP/Rhône-Poulenc) and laser-induced thrombi in rat mesenteric vessels. | 1989 | Haemostasis | pmid:2807041 |
| Guarner F et al. | Endotoxin-induced ascites formation in the rat: partial mediation by platelet-activating factor. | 1989 | Hepatology | pmid:2807157 |
| Kaminker AJ and Carreras LO | [Physiopathology of thrombotic microangiopathy]. | 1989 | Sangre (Barc) | pmid:2667170 |
| Mizushima H et al. | Purification of rabbit platelet secretory phospholipase A2 and its characteristics. | 1989 | J. Biochem. | pmid:2668261 |
| Harper MJ | Platelet-activating factor: a paracrine factor in preimplantation stages of reproduction? | 1989 | Biol. Reprod. | pmid:2669984 |
| Page C and Abbott A | PAF: new antagonists, new roles in disease and a major role in reproductive biology. | 1989 | Trends Pharmacol. Sci. | pmid:2672467 |
| Braquet P et al. | The role of platelet-activating factor in cerebral ischemia and related disorders. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2672941 |
| Badr KF et al. | Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. | 1989 | Am. J. Physiol. | pmid:2912165 |
| Oh-ishi S et al. | Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetate. | 1989 | Dermatologica | pmid:2673856 |
| Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
| Filep J et al. | Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2916986 |
| Tilley JW et al. | Biphenylcarboxamide derivatives as antagonists of platelet-activating factor. | 1989 | J. Med. Chem. | pmid:2754708 |
| Camoratto AM and Grandison L | Platelet-activating factor stimulates prolactin release from dispersed rat anterior pituitary cells in vitro. | 1989 | Endocrinology | pmid:2917522 |
| Guthrie RW et al. | Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor. | 1989 | J. Med. Chem. | pmid:2754709 |
| Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
| Oda M et al. | [Platelet-activating factor producing cell--target cell interactions]. | 1989 | Rinsho Byori | pmid:2754814 |
| Adamus WS et al. | Safety, tolerability, and pharmacologic activity of multiple doses of the new platelet activating factor antagonist WEB 2086 in human subjects. | 1989 | Clin. Pharmacol. Ther. | pmid:2920502 |
| Rogers DF et al. | Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo. | 1989 | J Pharmacol Methods | pmid:2755146 |
| Kroegel C et al. | Characterization of platelet-activating factor-induced elevation of cytosolic free calcium concentration in eosinophils. | 1989 | FEBS Lett. | pmid:2920824 |
| Nolte D | [Platelet activating factor produces platelet activating factor, comes to nothing]. | 1989 | Med. Klin. (Munich) | pmid:2755413 |
| Joseph R and Welch KM | Granulocytes, platelet activating factor, and stroke. | 1989 | Stroke | pmid:2756548 |
| Pretolani M et al. | From anti-asthma drugs to PAF-acether antagonism and back. Present status. | 1989 | Biochem. Pharmacol. | pmid:2655601 |
| Esplugues JV and Whittle BJ | Gastric effects of PAF. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2657290 |
| Makino S | [Platelet-activating factor and disease]. | 1989 | Kokyu To Junkan | pmid:2657915 |
| Townley RG et al. | Platelet-activating factor and airway reactivity. | 1989 | J. Allergy Clin. Immunol. | pmid:2659646 |
| Trebien HA and Calixto JB | Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom. | 1989 | Agents Actions | pmid:2660497 |
| Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
| Bruijnzeel PL et al. | Inhibitory effects of nedocromil sodium on the in vitro induced migration and leukotriene formation of human granulocytes. | 1989 | Drugs | pmid:2547570 |
| Spina D et al. | The role of platelet activating factor in allergic inflammation. | 1989 | Pulm Pharmacol | pmid:2520484 |
| De Vos C et al. | Inhibition of human eosinophil chemotaxis and of the IgE-dependent stimulation of human blood platelets by cetirizine. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2523357 |
| Hemmendinger S et al. | Platelet function: aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. | 1989 | J. Allergy Clin. Immunol. | pmid:2523922 |
| Kaufman SE et al. | Effects of human GM-CSF on neutrophil degranulation in vitro. | 1989 | Exp. Hematol. | pmid:2502423 |
| Marx MH et al. | Darmstoff analogues. 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle. | 1989 | J. Med. Chem. | pmid:2724301 |
| Cucala M et al. | CNS effects of platelet-activating factor on the rat stomach. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2725123 |
| Schirmer WJ et al. | Systemic and renal hemodynamic response to platelet activating factor. | 1989 | Prog. Clin. Biol. Res. | pmid:2726980 |
| Skvortsov AA et al. | [New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy]. | 1989 | Ter. Arkh. | pmid:2727928 |
| Desquand S et al. | Antigen-induced bronchopulmonary alterations in the guinea pig: a new model of passive sensitization mediated by mouse IgE antibodies. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2731996 |
| Binnaka T et al. | Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595311 |
| Hatakeyama K et al. | Platelet activating factor induced gastric damage in rats: participation of increased gastric vascular permeability. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595312 |
| GarcÃa-Sáinz JA | Intercellular communication within the liver has clinical implications. | 1989 | Trends Pharmacol. Sci. | pmid:2595791 |
| Koenderman L et al. | 1,2-Diacylglycerol accumulation in human neutrophils does not correlate with respiratory burst activation. | 1989 | FEBS Lett. | pmid:2597277 |
| Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
| Omann GM et al. | Oscillating actin polymerization/depolymerization responses in human polymorphonuclear leukocytes. | 1989 | J. Biol. Chem. | pmid:2550438 |
| Heidel JR et al. | Characterization of arachidonic acid metabolism, superoxide production, and bacterial killing in bovine circulating neutrophils and elicited alveolar neutrophils. | 1989 | J. Leukoc. Biol. | pmid:2543724 |
| Chau LY et al. | Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2545193 |
| Thierry A et al. | Presence of specific platelet-activating factor binding sites in the rat retina. | 1989 | Eur. J. Pharmacol. | pmid:2545464 |
| Marquis O et al. | Evidence for the existence and ionic modulation of platelet-activating factor receptors mediating degranulatory responses in human polymorphonuclear leukocytes. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2545861 |
| Braquet P et al. | Effect of platelet-activating factor on platelets and vascular endothelium. | 1989 | Semin. Thromb. Hemost. | pmid:2546255 |
| Kraemer R and Mullane KM | Neutrophils delay functional recovery of the post-hypoxic heart of the rabbit. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553929 |
| Ichikawa Y et al. | [Effect of glycyrrhizin on the production of platelet-activating factor from rat peritoneal exudate cells]. | 1989 | Arerugi | pmid:2783037 |