Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Argyrou C et al. Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. 2017 Prostaglandins Other Lipid Mediat. pmid:28323197
Xanthopoulou MN et al. Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men. 2017 Eur J Nutr pmid:26936842
Malavige GN and Ogg GS Pathogenesis of vascular leak in dengue virus infection. 2017 Immunology pmid:28437586
Shindou H et al. Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. 2017 FASEB J. pmid:28341636
Kispert SE et al. Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. 2017 Physiol Rep pmid:28270596
Noh KT et al. Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. 2017 J. Biol. Chem. pmid:28077574
Sanz-Vicente I et al. Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. 2017 Anal. Biochem. pmid:27956151
Kulinski JM et al. Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. 2016 Eur. J. Pharmacol. pmid:25941085
Vadas P The platelet-activating factor pathway in food allergy and anaphylaxis. 2016 Ann. Allergy Asthma Immunol. pmid:27788869
Pike DP et al. Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. 2016 Lipids pmid:27757707
Täubel J et al. Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. 2016 PLoS ONE pmid:27632557
Hoenderdos K et al. Hypoxia upregulates neutrophil degranulation and potential for tissue injury. 2016 Thorax pmid:27581620
Wang M et al. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. 2016 Life Sci. pmid:26808090
Bihl JC et al. UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. 2016 Photochem. Photobiol. pmid:26876152
Reiner B et al. Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. 2016 Neurosci. Lett. pmid:26808643
Unsal E et al. Effects of pentoxifylline and platelet activating factor on sperm DNA damage. 2016 Eur. J. Obstet. Gynecol. Reprod. Biol. pmid:26748389
Park JH et al. Glucosamine suppresses platelet-activating factor-induced activation of microglia through inhibition of store-operated calcium influx. 2016 Environ. Toxicol. Pharmacol. pmid:26745504
Rodríguez M et al. Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. 2016 Biochem. Pharmacol. pmid:26673542
Aquino EN et al. Proteomic Analysis of Neutrophil Priming by PAF. 2016 Protein Pept. Lett. pmid:26631175
Kim HK et al. Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. 2016 Int. Arch. Allergy Immunol. pmid:27838690