| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lie WJ et al. | Degranulation of human basophils by picomolar concentrations of IL-3, IL-5, or granulocyte-macrophage colony-stimulating factor. | 1998 | J. Allergy Clin. Immunol. | pmid:9600507 |
| Yamada M et al. | Inhibition of tumor necrosis factor-alpha production by SK&F 98625, a CoA-independent transacylase inhibitor, in cultured rat peritoneal macrophages. | 1998 | Life Sci. | pmid:9600332 |
| Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
| Colak O et al. | The effect of Ginkgo biloba on the activity of catalase and lipid peroxidation in experimental strangulation ileus. | 1998 | Int. J. Clin. Lab. Res. | pmid:9594365 |
| Jackson JR et al. | The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis. | 1998 | Biochim. Biophys. Acta | pmid:9593866 |
| Pietsch P et al. | Effects of platelet-activating factor on intracellular Ca2+ concentration and contractility in isolated cardiomyocytes. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9593076 |
| Takasaki J et al. | Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism. | 1998 | J. Immunol. | pmid:9590257 |
| Hüseyinov A et al. | Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in steroid sensitive nephrotic syndrome of childhood. | 1998 | Acta Paediatr Jpn | pmid:9583202 |
| Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| Kitayama J et al. | The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. | 1998 | J. Clin. Invest. | pmid:9576767 |
| Thijs A and Thijs LG | Pathogenesis of renal failure in sepsis. | 1998 | Kidney Int. Suppl. | pmid:9573570 |
| Cines DB et al. | Endothelial cells in physiology and in the pathophysiology of vascular disorders. | 1998 | Blood | pmid:9572988 |
| Snapper JR et al. | Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep. | 1998 | J. Appl. Physiol. | pmid:9572806 |
| Ruiz-Ortega M et al. | Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating-factor stimulation. | 1998 | Nephrol. Dial. Transplant. | pmid:9568845 |
| Ezeamuzie CI et al. | The effect of salmeterol on human eosinophils is both stimulus- and response-dependent. | 1997 | Int. J. Immunopharmacol. | pmid:9568547 |
| Brunet J et al. | In vitro antioxidant properties of calcium dobesilate. | 1998 | Fundam Clin Pharmacol | pmid:9565776 |
| da Silva MB et al. | Effect of ketoprofen on PAF-induced bovine platelet aggregation. | 1998 | Vet. J. | pmid:9564275 |
| Akiyama M et al. | Identification of a major PAF acetylhydrolase in human serum/plasma as a 43 kDa glycoprotein containing about 9 kDa asparagine-conjugated sugar chain(s). | 1998 | J. Biochem. | pmid:9562606 |
| Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
| Heller A et al. | Lipid mediators in inflammatory disorders. | 1998 | Drugs | pmid:9561339 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
| Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
| Cherniad'eva IF et al. | [Characteristics of development of oxidative stress in blood plasma of patients with familial hypercholesterolemia]. | 1998 | Biull Eksp Biol Med | pmid:9559141 |
| Partrick DA et al. | Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release. | 1998 | J Trauma | pmid:9555828 |
| Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |
| Bonsignore L et al. | One-step synthesis and pharmacological activity of new (N-substituted)amino-spiroalkan-dione derivatives. | 1997 | Farmaco | pmid:9550091 |
| Ishii I et al. | Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. | 1998 | J. Biol. Chem. | pmid:9545329 |
| Yamada T et al. | Effects of inhaled nitric oxide on platelet-activating factor-induced pulmonary hypertension in dogs. | 1998 | Acta Anaesthesiol Scand | pmid:9542566 |
| Michibayashi T | Different types of vasocontractile responses to noradrenaline in the presence of platelets with platelet activating factor. | 1997 | J Smooth Muscle Res | pmid:9533823 |
| Ostrovsky L et al. | A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. | 1998 | Blood | pmid:9531616 |
| Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
| Mabilat-Pragnon C et al. | Urokinase localization and activity in isolated eosinophils. | 1997 | Thromb. Res. | pmid:9526961 |
| Kulikov VI and Muzya GI | The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions. | 1998 | Biochemistry Mosc. | pmid:9526094 |
| Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
| Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
| Lopes-Martins RA et al. | The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release. | 1997 | J Lipid Mediat Cell Signal | pmid:9524924 |
| Yoshikawa T et al. | alpha-Tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells. | 1998 | Biofactors | pmid:9523024 |
| Evangelista S et al. | Antihistaminic and antiallergic properties of dextro-mequitamium iodide in upper and lower guinea pig airways: comparison with azelastine. | 1998 | Gen. Pharmacol. | pmid:9522168 |
| Lukiw WJ et al. | Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520467 |
| Tsuji H et al. | The presence of platelet-activating factor-acetylhydrolase in human middle ear effusions. | 1998 Jan-Feb | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:9519378 |
| Cannon TR et al. | Mechanisms of acute vasodilator response to bacterial lipopolysaccharide in the rat coronary microcirculation. | 1998 | Br. J. Pharmacol. | pmid:9517382 |
| Shindo K et al. | Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. | 1997 | Thorax | pmid:9516893 |
| Chung KF | Platelet activating factor revisited. | 1997 | Thorax | pmid:9516891 |
| Balsa D et al. | Effects of a new platelet-activating factor antagonist, UR-12670, on several endotoxic shock markers in rats. | 1997 | Drugs Exp Clin Res | pmid:9515229 |
| Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
| Qayumi KA et al. | A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. | 1997 | Cardiovasc Drugs Ther | pmid:9512873 |
| Fink MP | Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511090 |
| Wilson PG et al. | Acute pancreatitis as a model of sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511087 |
| Roy Baker R and Chang H | Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors. | 1998 | Biochim. Biophys. Acta | pmid:9507140 |
| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Pettit EJ and Hallett MB | Ca2+ signalling delays in neutrophils: effects of prior exposure to platelet activating factor or formyl-met-leu-phe. | 1998 | Cell. Signal. | pmid:9502117 |
| Moritani C et al. | Activation of platelets in bronchial asthma. | 1998 | Chest | pmid:9498966 |
| Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |
| Yang HO and Han BH | Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis. | 1998 | Planta Med. | pmid:9491770 |
| Matusiewicz R and Rotkiewicz-Piorun A | Inflammatory cells in skin immunological infiltrations. | 1997 Nov-Dec | J Investig Allergol Clin Immunol | pmid:9491202 |
| Shi LC et al. | Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line. | 1998 | J. Neurochem. | pmid:9489723 |
| Borman RA et al. | Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro. | 1998 | Br. J. Pharmacol. | pmid:9489610 |
| Yamawaki I et al. | Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9485521 |
| Ezeamuzie CI and Al-Hage M | Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. | 1998 | Int. Arch. Allergy Immunol. | pmid:9482706 |
| Wise H | Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482170 |
| Jocks T et al. | Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury. | 1998 | Nephrol. Dial. Transplant. | pmid:9481713 |
| Abu-Zidan FM | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1998 | Surgery | pmid:9481416 |
| Erickson KL | Dietary fat, breast cancer, and nonspecific immunity. | 1998 | Nutr. Rev. | pmid:9481130 |
| Mason GR et al. | Appropriate background correction for DTPA aerosol clearance. | 1998 | J. Appl. Physiol. | pmid:9480975 |
| Antonopoulou S et al. | Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. | 1998 | Biochem. J. | pmid:9480892 |
| Péterfy M et al. | Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. | 1998 | Genomics | pmid:9479492 |
| Renis M et al. | Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. | 1998 | Brain Res. | pmid:9479063 |
| Jung KY et al. | Platelet activating factor antagonist activity of ginsenosides. | 1998 | Biol. Pharm. Bull. | pmid:9477174 |
| Miotla JM et al. | Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9476906 |
| Thakur A et al. | The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: homeostatic mechanisms. | 1998 | J. Clin. Immunol. | pmid:9475355 |
| Chupin VV et al. | On the synthesis of platelet-activating factor via acetylation of 1-alkyl-sn-glycero-3-phosphocholine. Formation of structural isomer of PAF in the presence of bases. | 1996 | Chem. Phys. Lipids | pmid:9471401 |
| Golubeva TS et al. | [Determination of the nucleosomal fragmentation of DNA of ACL cells during their incubation with human platelets]. | 1997 | Biull Eksp Biol Med | pmid:9471253 |
| Singh N et al. | Possible mechanism of alprazolam-induced amnesia in mice. | 1998 | Pharmacology | pmid:9467187 |
| Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
| Wang HG et al. | The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. | 1998 | Shock | pmid:9466475 |
| Kruse-Elliott KT et al. | Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. | 1998 | Shock | pmid:9466472 |
| Winkler JD et al. | Beta-lactams SB 212047 and SB 216754 are irreversible, time-dependent inhibitors of coenzyme A-independent transacylase. | 1998 | Mol. Pharmacol. | pmid:9463491 |
| Sibelius U et al. | Wegener's granulomatosis: anti-proteinase 3 antibodies are potent inductors of human endothelial cell signaling and leakage response. | 1998 | J. Exp. Med. | pmid:9463400 |
| Kulikov VI and Muzya GI | Ether lipids and platelet-activating factor: evolution and cellular function. | 1997 | Biochemistry Mosc. | pmid:9461631 |
| Cao Y et al. | Expression of plasma platelet-activating factor acetylhydrolase is transcriptionally regulated by mediators of inflammation. | 1998 | J. Biol. Chem. | pmid:9461591 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Oancea E et al. | Green fluorescent protein (GFP)-tagged cysteine-rich domains from protein kinase C as fluorescent indicators for diacylglycerol signaling in living cells. | 1998 | J. Cell Biol. | pmid:9456311 |
| Hirashima Y et al. | Platelet-activating factor and edema surrounding meningiomas. | 1998 | J. Neurosurg. | pmid:9452240 |
| Akagi M et al. | Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. | 1997 | Arzneimittelforschung | pmid:9450165 |
| Shah BH et al. | Role of phosphatidylinositol 3-kinase in human platelet aggregation. | 1997 | Biochem. Soc. Trans. | pmid:9450028 |
| van der Bruggen T et al. | Cytokine-induced protein tyrosine phosphorylation is essential for cytokine priming of human eosinophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9449508 |
| Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
| Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
| Nilsson J et al. | Lipoprotein-like phospholipid particles inhibit the smooth muscle cell cytotoxicity of lysophosphatidylcholine and platelet-activating factor. | 1998 | Arterioscler. Thromb. Vasc. Biol. | pmid:9445250 |
| LeVan TD et al. | Platelet-activating factor induction of activator protein-1 signaling in bronchial epithelial cells. | 1998 | Mol. Pharmacol. | pmid:9443941 |
| Murohara T et al. | Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin. | 1998 Jan 6-13 | Circulation | pmid:9443437 |
| Sugimoto Y et al. | Effects of apafant on PAF-induced downregulation of beta-adrenoceptors in guinea pigs. | 1997 | Methods Find Exp Clin Pharmacol | pmid:9442478 |
| Lee EK and Kehrli ME | Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. | 1998 | Am. J. Vet. Res. | pmid:9442240 |
| Kokura S et al. | Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats. | 1997 | Dig. Dis. Sci. | pmid:9440637 |
| De Matos IM et al. | Lung oedema induced by Tityus serrulatus scorpion venom in the rat. | 1997 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9440240 |
| Curtin ML et al. | Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. | 1998 | J. Med. Chem. | pmid:9438024 |
| Tsoukatos DC et al. | Copper-catalyzed oxidation mediates PAF formation in human LDL subspecies. Protective role of PAF:acetylhydrolase in dense LDL. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9437199 |
| Gamaley IA et al. | Superoxide release is involved in membrane potential changes in mouse peritoneal macrophages. | 1998 | Free Radic. Biol. Med. | pmid:9436627 |