| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herndon B et al. | Urease and Helicobacter spp. antigens in pulmonary granuloma. | 2013 | J. Comp. Pathol. | pmid:22901429 |
| Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
| Sato A et al. | An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. | 2013 | Eur. J. Pharmacol. | pmid:23792041 |
| Ayaz G et al. | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. | 2013 | Gene | pmid:23816407 |
| Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
| Wang C et al. | Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. | 2013 | Lipids Health Dis | pmid:23805935 |
| Nettis E et al. | Rupatadine for the treatment of urticaria. | 2013 | Expert Opin Pharmacother | pmid:23806068 |
| Sato A and Ebina K | [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. | 2013 | Seikagaku | pmid:23819394 |
| Compalati E and Canonica GW | Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. | 2013 | Curr Med Res Opin | pmid:23826741 |
| Xu H et al. | Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. | 2013 | FEBS J. | pmid:23826908 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Motoyama N et al. | Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. | 2013 | Eur J Pain | pmid:23355413 |
| Tsoupras AB et al. | Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. | 2013 | J. Inorg. Biochem. | pmid:23318288 |
| Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
| Vanstreels L and Merk HF | [Value of in-vitro diagnostic tools after anaphylaxis]. | 2013 | Hautarzt | pmid:23385619 |
| Sato A and Ebina K | Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. | 2013 | Inflamm. Res. | pmid:23370722 |
| Singh P et al. | Platelet-activating factor (PAF)-antagonists of natural origin. | 2013 | Fitoterapia | pmid:23160091 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
| Murakami M and Lambeau G | Emerging roles of secreted phospholipase A(2) enzymes: an update. | 2013 | Biochimie | pmid:23022039 |
| Vadas P et al. | Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. | 2013 | J. Allergy Clin. Immunol. | pmid:23040367 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
| Maziero AM et al. | Inhibition of human platelet aggregation by eosinophils. | 2013 | Life Sci. | pmid:23871985 |
| Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
| Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
| Sahu RP et al. | Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. | 2013 | J. Immunol. | pmid:23355733 |
| Berman B and Cockerell CJ | Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. | 2013 | J. Am. Acad. Dermatol. | pmid:23228301 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Renteria LS et al. | RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. | 2013 | Cell Prolif. | pmid:24033386 |
| Verouti SN et al. | Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. | 2013 | Int J Artif Organs | pmid:23335378 |
| Zhao C et al. | Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. | 2013 | PLoS ONE | pmid:24367540 |
| Barbier M et al. | Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. | 2013 | MBio | pmid:23653444 |
| Sahu RP et al. | Platelet-activating factor does not mediate UVB-induced local immune suppression. | 2012 Mar-Apr | Photochem. Photobiol. | pmid:22211638 |
| Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
| Chini M et al. | Effects of highly active antiretroviral therapy on platelet activating factor metabolism in naive HIV-infected patients: ii) study of the abacavir/lamivudine/efavirenz HAART regimen. | 2012 Jan-Mar | Int J Immunopathol Pharmacol | pmid:22507337 |
| Neerhof MG et al. | The significance of endothelin in platelet-activating factor-induced fetal growth restriction. | 2012 | Reprod Sci | pmid:22534337 |
| Muehlmann LA et al. | PAF increases phagocytic capacity and superoxide anion production in equine alveolar macrophages and blood neutrophils. | 2012 | Res. Vet. Sci. | pmid:21820686 |
| Kim HA et al. | Glutamine inhibits platelet-activating factor-mediated pulmonary tumour metastasis. | 2012 | Eur. J. Cancer | pmid:21889331 |
| Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
| Xiong J et al. | New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation. | 2012 | Eur J Pharm Sci | pmid:22285483 |
| Flaherty MM et al. | Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice. | 2012 | Toxicol. Sci. | pmid:22025730 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces respiratory burst, MMP-9 release and CD11b expression, and increases l-selectin shedding in bovine neutrophils. | 2012 | Res. Vet. Sci. | pmid:21071047 |
| Akbarshahi H et al. | Acute lung injury in acute pancreatitis--awaiting the big leap. | 2012 | Respir Med | pmid:22749752 |
| Kolovou V et al. | Platelet activating factor levels and metabolism in Tangier disease: a case study. | 2012 | Lipids Health Dis | pmid:22769014 |
| Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
| Liu M et al. | Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion. | 2012 | PLoS Pathog. | pmid:22496650 |
| Vadas P and Perelman B | Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells. | 2012 | J. Allergy Clin. Immunol. | pmid:22460068 |