Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Watschinger K and Werner ER Orphan enzymes in ether lipid metabolism. 2013 Biochimie pmid:22771767
Nasopoulou C et al. Hen egg yolk lipid fractions with antiatherogenic properties. 2013 Anim. Sci. J. pmid:23480708
Sato A et al. An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. 2013 Eur. J. Pharmacol. pmid:23792041
Ayaz G et al. The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. 2013 Gene pmid:23816407
Yamazaki Y et al. A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. 2013 Biochem. Pharmacol. pmid:23817078
Xia SH et al. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. 2013 World J. Gastroenterol. pmid:23840141
Mazereeuw G et al. Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. 2013 Neurosci Biobehav Rev pmid:23800745
Wang C et al. Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. 2013 Lipids Health Dis pmid:23805935
Nettis E et al. Rupatadine for the treatment of urticaria. 2013 Expert Opin Pharmacother pmid:23806068
Sato A and Ebina K [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. 2013 Seikagaku pmid:23819394
Compalati E and Canonica GW Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. 2013 Curr Med Res Opin pmid:23826741
Xu H et al. Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. 2013 FEBS J. pmid:23826908
Liu G et al. Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. 2013 Infect. Immun. pmid:23774595
Tokuoka SM et al. Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. 2013 Biochem. Biophys. Res. Commun. pmid:23743196
Stanca E et al. Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin. 2013 Biochim. Biophys. Acta pmid:23851051
Nagase T [Respiratory failure]. 2013 Nippon Rinsho pmid:23855209
Vanstreels L and Merk HF [Value of in-vitro diagnostic tools after anaphylaxis]. 2013 Hautarzt pmid:23385619
Sato A and Ebina K Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. 2013 Inflamm. Res. pmid:23370722
Singh P et al. Platelet-activating factor (PAF)-antagonists of natural origin. 2013 Fitoterapia pmid:23160091
Costa M et al. Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. 2013 Stem Cell Res pmid:23164599
Sirangelo I et al. Amyloid toxicity and platelet-activating factor signaling. 2013 J. Cell. Physiol. pmid:23169529
Murakami M and Lambeau G Emerging roles of secreted phospholipase A(2) enzymes: an update. 2013 Biochimie pmid:23022039
Vadas P et al. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. 2013 J. Allergy Clin. Immunol. pmid:23040367
Kawano DF and Carvalho I Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. 2013 Mini Rev Med Chem pmid:23544467
Wei JF et al. Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. 2013 Biomed Res Int pmid:23509689
Forsman H et al. Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. 2013 PLoS ONE pmid:23555913
Borthakur A et al. Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. 2013 PLoS ONE pmid:24130731
Predescu S et al. Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. 2013 PLoS ONE pmid:24086643
Sahu RP et al. Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. 2013 J. Immunol. pmid:23355733
Berman B and Cockerell CJ Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. 2013 J. Am. Acad. Dermatol. pmid:23228301
Frost BL and Caplan MS Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. 2013 Semin. Pediatr. Surg. pmid:23611612
Renteria LS et al. RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. 2013 Cell Prolif. pmid:24033386
Verouti SN et al. Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. 2013 Int J Artif Organs pmid:23335378
Zhao C et al. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. 2013 PLoS ONE pmid:24367540
Barbier M et al. Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. 2013 MBio pmid:23653444
Sahu RP et al. Platelet-activating factor does not mediate UVB-induced local immune suppression. 2012 Mar-Apr Photochem. Photobiol. pmid:22211638
Zia-ul-Haq M et al. Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. 2012 Jul-Aug Acta Pol Pharm pmid:22876614
Chini M et al. Effects of highly active antiretroviral therapy on platelet activating factor metabolism in naive HIV-infected patients: ii) study of the abacavir/lamivudine/efavirenz HAART regimen. 2012 Jan-Mar Int J Immunopathol Pharmacol pmid:22507337
Werner J et al. Multidrug strategies are effective in the treatment of severe experimental pancreatitis. 2012 Surgery pmid:21982067
Xiong J et al. New peptide pENW (pGlu-Asn-Trp) inhibits platelet activation by attenuating Akt phosphorylation. 2012 Eur J Pharm Sci pmid:22285483
Flaherty MM et al. Nonclinical evaluation of GMA161--an antihuman CD16 (FcγRIII) monoclonal antibody for treatment of autoimmune disorders in CD16 transgenic mice. 2012 Toxicol. Sci. pmid:22025730
Sharma J et al. Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure. 2012 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:21984569
Samapati R et al. Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. 2012 Am. J. Respir. Crit. Care Med. pmid:22246702
Liu M et al. Group A Streptococcus secreted esterase hydrolyzes platelet-activating factor to impede neutrophil recruitment and facilitate innate immune evasion. 2012 PLoS Pathog. pmid:22496650
Vadas P and Perelman B Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells. 2012 J. Allergy Clin. Immunol. pmid:22460068
Zheng GH et al. Elevated plasma platelet activating factor, platelet activating factor acetylhydrolase levels and risk of coronary heart disease or blood stasis syndrome of coronary heart disease in Chinese: a case control study: a case-control study. 2012 Inflammation pmid:22430230
Bai J et al. Sesquiterpenes from the roots of Illicium dunnianum. 2012 Phytochemistry pmid:22695122
Masliakov VV et al. [Microcirculation in the injured spleen by different operations in children]. 2012 Khirurgiia (Mosk) pmid:23257700
Liu C et al. Clinical significance and expression of PAF and TNF-alpha in seminal plasma of leukocytospermic patients. 2012 Mediators Inflamm. pmid:23209346
Zhang XT et al. [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. 2012 Zhong Yao Cai pmid:23213741