| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Koyama S et al. | Type II pneumocytes release chemoattractant activity for monocytes constitutively. | 1997 | Am. J. Physiol. | pmid:9176245 |
| Despotis GJ et al. | Effects of platelets and white blood cells and antiplatelet agent C7E3 (Reopro) on a new test of PAF procoagulant activity of whole blood. | 1997 | Thromb. Res. | pmid:9175242 |
| Leoncini G et al. | Hyperactivity and increased hydrogen peroxide formation in platelets of NIDDM patients. | 1997 | Thromb. Res. | pmid:9175236 |
| Shindo K et al. | Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175174 |
| Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. II. Hydrophobicity study using the molecular lipophilicity potential. | 1997 | J Lipid Mediat Cell Signal | pmid:9172050 |
| Chen J and Giris N | Species differences in PAF receptor binding in the lungs between hamster and guinea pig. | 1997 | J Lipid Mediat Cell Signal | pmid:9172049 |
| Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
| Herrero-Beaumont G and Egido J | PAF, a potent proinflammatory mediator, looking for its role in the pathogenesis of joint damage. | 1997 | Ann. Rheum. Dis. | pmid:9165991 |
| Berends C et al. | Inhibition of PAF-induced expression of CD11b and shedding of L-selectin on human neutrophils and eosinophils by the type IV selective PDE inhibitor, rolipram. | 1997 | Eur. Respir. J. | pmid:9163638 |
| Walker BA et al. | Adenosine A3 receptor expression and function in eosinophils. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9160835 |
| Ammit AJ and O'Neill C | Optimization of a method for deactivation of platelet-activating factor:acetylhydrolase in serum for use in in-vitro fertilization culture media. | 1997 | Hum. Reprod. | pmid:9159443 |
| Frostegård J et al. | Platelet-activating factor and oxidized LDL induce immune activation by a common mechanism. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157962 |
| Stengel D et al. | Expression of the PAF receptor in human monocyte-derived macrophages is downregulated by oxidized LDL: relevance to the inflammatory phase of atherogenesis. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9157961 |
| El-Shazly AE et al. | Immunoregulatory effect of substance P in human eosinophil migratory function. | 1996 | Immunol. Invest. | pmid:9157054 |
| Froon AM et al. | Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. | 1996 | Shock | pmid:9156785 |
| Petersen LJ et al. | Platelet-activating factor induces histamine release from human skin mast cells in vivo, which is reduced by local nerve blockade. | 1997 | J. Allergy Clin. Immunol. | pmid:9155831 |
| Velasquez LA et al. | Expression of platelet-activating factor receptor in the hamster oviduct: localization to the endosalpinx. | 1997 | J. Reprod. Fertil. | pmid:9155745 |
| Ammit AJ and O'Neill C | The role of albumin in the release of platelet-activating factor by mouse preimplantation embryos in vitro. | 1997 | J. Reprod. Fertil. | pmid:9155741 |
| Lash GE and Legge M | Induction of early pregnancy factor activity in vitro by platelet-activating factor in mice. | 1997 | J. Reprod. Fertil. | pmid:9155726 |
| Bussolati B et al. | Modulatory effect of interleukin-10 on the production of platelet-activating factor and superoxide anions by human leucocytes. | 1997 | Immunology | pmid:9155653 |
| Bazan NG and Allan G | Signal transduction and gene expression in the eye: a contemporary view of the pro-inflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. | 1997 | Surv Ophthalmol | pmid:9154273 |
| Lehr HA et al. | Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. | 1997 | J. Clin. Invest. | pmid:9153277 |
| FitzGerald GA | Cigarettes and the wages of sn-2: oxidized species of PAF in smoking hamsters. | 1997 | J. Clin. Invest. | pmid:9153267 |
| Sei Y et al. | Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS. | 1997 | Eur. J. Pharmacol. | pmid:9151942 |
| Albert DH et al. | Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist. | 1997 | Eur. J. Pharmacol. | pmid:9151941 |
| Tokumura A et al. | Exogenously added alkylmethylglycerophosphocholine and alkylmethylcarbamylglycerophosphocholine accumulate in plasma membranes more than in intracellular membranes of rabbit platelets. | 1997 | Chem. Phys. Lipids | pmid:9149390 |
| Teixeira MM et al. | Characterization of the prostanoid receptors mediating inhibition of PAF-induced aggregation of guinea-pig eosinophils. | 1997 | Br. J. Pharmacol. | pmid:9146890 |
| Nakayama R et al. | Changes in PAF (platelet-activating factor) production during cell cycle of yeast Saccharomyces cerevisiae. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9145522 |
| Schurr MJ et al. | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1997 | Surgery | pmid:9142146 |
| Jones RE | Synthesis of ether lipids and phosphatidylethanolamine by ejaculated human spermatozoa. | 1997 May-Jun | Arch. Androl. | pmid:9140614 |
| Caplan MS et al. | The platelet-activating factor receptor antagonist WEB 2170 prevents neonatal necrotizing enterocolitis in rats. | 1997 | J. Pediatr. Gastroenterol. Nutr. | pmid:9138176 |
| Bito H et al. | Molecular cloning of a novel type of somatostatin receptor and platelet-activating factor receptor cDNAs from rat. | 1993 | Ann. N. Y. Acad. Sci. | pmid:9137600 |
| Nogami K et al. | Involvement of platelet-activating factor (PAF) in glutamate neurotoxicity in rat neuronal cultures. | 1997 | Brain Res. | pmid:9134961 |
| Bazan HE and Varner L | A mitogen-activated protein kinase (MAP-kinase) cascade is stimulated by platelet activating factor (PAF) in corneal epithelium. | 1997 | Curr. Eye Res. | pmid:9134327 |
| Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
| Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
| McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
| Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
| Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
| Ferby I et al. | PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. | 1996 | Adv. Exp. Med. Biol. | pmid:9131167 |
| Yang HC et al. | Characterization of plasmalogen-selective phospholipase A2 from bovine brain. | 1996 | Adv. Exp. Med. Biol. | pmid:9131165 |
| Zimmerman GA et al. | Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions. | 1996 | Adv. Exp. Med. Biol. | pmid:9131163 |
| Korth RM | Non-specific PAF binding to embryonal F9 cells and prostacyclin synthesis in human umbilical vein endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131162 |
| Ahmed A and Dearn S | The role of platelet-activating factor and its receptor in endometrial receptivity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131161 |
| Narahara H et al. | Role of platelet-activating factor in parturition. | 1996 | Adv. Exp. Med. Biol. | pmid:9131160 |
| Ammit AJ and O'Neill C | PAF released by preimplantation embryos binds to albumin. | 1996 | Adv. Exp. Med. Biol. | pmid:9131159 |
| O'Neill C | PAF promotes the development of the preimplantation embryo. | 1996 | Adv. Exp. Med. Biol. | pmid:9131158 |
| Tetta C et al. | The role of platelet-activating factor in the biocompatibility of hemodialysis membranes. | 1996 | Adv. Exp. Med. Biol. | pmid:9131156 |
| Oh-Ishi S et al. | Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131154 |
| Camussi G et al. | Platelet-activating factor and angiogenesis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131153 |
| Lopes-Martins RA et al. | Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. | 1996 | Adv. Exp. Med. Biol. | pmid:9131152 |
| Silver D et al. | Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131151 |
| Saito K | PAF response to inflammatory and non-inflammatory stimuli. | 1996 | Adv. Exp. Med. Biol. | pmid:9131150 |
| Sanchez Crespo M et al. | Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. | 1996 | Adv. Exp. Med. Biol. | pmid:9131148 |
| Morooka S and Natsume Y | Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131147 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
| Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
| Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
| Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
| Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
| Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
| Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
| Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
| Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
| van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
| Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
| Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
| Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
| Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
| Snyder F et al. | Biosynthesis of platelet-activating factor and enzyme inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131118 |
| Hanahan DJ | The continuing biochemical challenge of PAF and closely related lipid mediators. | 1996 | Adv. Exp. Med. Biol. | pmid:9131117 |
| Isogai E et al. | Role of platelet-activating-factor (PAF) on cellular responses after stimulation with leptospire lipopolysaccharide. | 1997 | Microbiol. Immunol. | pmid:9130240 |
| He CF et al. | Postural vasoregulation and mediators of reperfusion injury in venous ulceration. | 1997 | J. Vasc. Surg. | pmid:9129619 |
| Teixeira MM and Hellewell PG | Evidence that the eosinophil is a cellular target for the inhibitory action of salmeterol on eosinophil recruitment in vivo. | 1997 | Eur. J. Pharmacol. | pmid:9128847 |
| Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
| Keskinoglu A et al. | Inflammatory lipid mediators and immunologic recognition in allogeneic renal transplantation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9122948 |
| Xia D and Samols D | Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia. | 1997 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9122237 |
| Milella M et al. | CD16 cross-linking induces both secretory and extracellular signal-regulated kinase (ERK)-dependent cytosolic phospholipase A2 (PLA2) activity in human natural killer cells: involvement of ERK, but not PLA2, in CD16-triggered granule exocytosis. | 1997 | J. Immunol. | pmid:9120268 |
| Im SY et al. | A protective role of platelet-activating factor in murine candidiasis. | 1997 | Infect. Immun. | pmid:9119469 |
| Miao FJ et al. | Contribution of adrenal hormones to nicotine-induced inhibition of synovial plasma extravasation in the rat. | 1997 | Br. J. Pharmacol. | pmid:9117123 |
| Le Solleu H et al. | Determination of a PAF antagonist pharmacophore using combined Molecular Electrostatic Potential and Molecular Lipophilicity Potential. | 1994 | Drug Des Discov | pmid:9116169 |
| Muguruma K and Johnston JM | Metabolism of platelet-activating factor in rat epididymal spermatozoa. | 1997 | Biol. Reprod. | pmid:9116157 |
| Greaves MW and Judge MR | Platelet activating factor in psoriasis. | 1997 | Br. J. Dermatol. | pmid:9115938 |
| Okada S et al. | Transmigration of eosinophils through basement membrane components in vitro: synergistic effects of platelet-activating factor and eosinophil-active cytokines. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115757 |
| Nauck M et al. | Induction of vascular endothelial growth factor by platelet-activating factor and platelet-derived growth factor is downregulated by corticosteroids. | 1997 | Am. J. Respir. Cell Mol. Biol. | pmid:9115750 |
| Ali H et al. | Role of phospholipase Cbeta3 phosphorylation in the desensitization of cellular responses to platelet-activating factor. | 1997 | J. Biol. Chem. | pmid:9115222 |
| Gentry PA et al. | An inherited platelet function defect in a Simmental crossbred herd. | 1997 | Can. J. Vet. Res. | pmid:9114964 |
| Nishiwaki H et al. | Prednisolone, platelet-activating factor receptor antagonist, or superoxide dismutase reduced leukocyte entrapment induced by interferon alpha in retinal microcirculation. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9112975 |
| Thielman NM et al. | Role of platelet-activating factor in Chinese hamster ovary cell responses to cholera toxin. | 1997 | J. Clin. Invest. | pmid:9109445 |
| Guerrant RL et al. | Diarrhea, demography and cell signaling: lessons from microbial toxins. | 1997 | Trans. Am. Clin. Climatol. Assoc. | pmid:9108674 |
| Konstantinov SM et al. | Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. | 1997 | Acta Trop. | pmid:9107362 |
| Baker RR and Chang HY | Neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor are located in the nuclear envelope and show differential losses in activity. | 1997 | Biochim. Biophys. Acta | pmid:9106499 |
| Silverstein FS et al. | Cytokines and perinatal brain injury. | 1997 Apr-May | Neurochem. Int. | pmid:9106251 |
| Takano H et al. | Effects of aminoguanidine on systemic inflammatory response syndrome induced by platelet activating factor and by lipopolysaccharide in rats. | 1997 | Eur. J. Pharmacol. | pmid:9105885 |
| Norman KE et al. | Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505. | 1997 | Br. J. Pharmacol. | pmid:9105704 |
| Toledano BJ et al. | Platelet-activating factor abrogates apoptosis induced by cross-linking of the surface IgM receptor in a human B lymphoblastoid cell line. | 1997 | J. Immunol. | pmid:9103434 |