Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Kono N et al. Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. 2008 J. Biol. Chem. pmid:18024956
Schaefer MB et al. Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. 2008 Eur. Respir. J. pmid:18653653
Samanta U and Bahnson BJ Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. 2008 J. Biol. Chem. pmid:18784071
Beuk RJ et al. Leucocyte and platelet adhesion in different layers of the small bowel during experimental total warm ischaemia and reperfusion. 2008 Br J Surg pmid:18720462
Kuliszkiewicz-Janus M et al. Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. 2008 Cell. Mol. Biol. Lett. pmid:17952375
Bélanger C et al. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. 2008 Immunology pmid:18217950
Figueiredo MB et al. Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments. 2008 J. Insect Physiol. pmid:18036540
Adamson RH et al. Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18178724
Gountopoulou A et al. TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. 2008 Cytokine pmid:18180165
Kwasniewski FH et al. Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. 2008 Int. Immunopharmacol. pmid:18182253
Chen Y et al. Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. 2008 World J. Gastroenterol. pmid:18186558
Hikiji H et al. The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. 2008 Prog. Lipid Res. pmid:18187046
Simonenko VB et al. [Losartan for the correction of thrombocyte activity in patients suffering from arterial hypertension with metabolic syndrome]. 2008 Klin Med (Mosk) pmid:18326282
Harayama T et al. Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. 2008 J. Biol. Chem. pmid:18285344
Mizutani T et al. Genuine functions of P-glycoprotein (ABCB1). 2008 Curr. Drug Metab. pmid:18288958
Fukunaga A et al. Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. 2008 J. Immunol. pmid:18292528
van Zoelen MA et al. Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. 2008 J. Immunol. pmid:18292561
Knapp S et al. Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. 2008 J. Immunol. pmid:18292574
Mullol J et al. Rupatadine in allergic rhinitis and chronic urticaria. 2008 Allergy pmid:18339040
Jiang Y et al. Three-dimensional localization and quantification of PAF-induced gap formation in intact venular microvessels. 2008 Am. J. Physiol. Heart Circ. Physiol. pmid:18515648
Su J et al. Natural antibodies against phosphorylcholine as potential protective factors in SLE. 2008 Rheumatology (Oxford) pmid:18522961
McLaughlin NJ et al. Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. 2008 J. Immunol. pmid:18523285
Felfernig M et al. Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. 2008 J R Nav Med Serv pmid:18524134
Tsoupras AB et al. Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? 2008 AIDS Res. Hum. Retroviruses pmid:18620493
Corl CM et al. Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. 2008 J. Dairy Sci. pmid:18650283
Landgraf RG et al. Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17923399
Vadnais ML et al. Current concepts of molecular events during bovine and porcine spermatozoa capacitation. 2007 May-Jun Arch. Androl. pmid:17612869
Rosenwasser L New insights into the pathophysiology of allergic rhinitis. 2007 Jan-Feb Allergy Asthma Proc pmid:17390750
Hattermann K et al. The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis. 2007 FASEB J. pmid:17264163
Boetkjaer A et al. Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells. 2007 Neurosci. Lett. pmid:17881124
Xu W et al. Role of platelet activating factor in pathogenesis of acute respiratory distress syndrome. 2007 Chin. Med. J. pmid:18028783
Li SQ et al. Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. 2007 Chin. Med. J. pmid:17908463
Doublier S et al. The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. 2007 Clin. Cancer Res. pmid:17908960
Shimada T et al. Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. 2007 J. Endocrinol. pmid:17911394
Whitehead SN et al. Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. 2007 Anal. Chem. pmid:17949058
Kawano Y et al. The effects of platelet-activating factor on the secretion of interleukin-8 and growth-regulated oncogene alpha in human immortalized granulosa cell line (GC1a). 2007 Am. J. Reprod. Immunol. pmid:17922696
Keam SJ and Plosker GL Rupatadine: a review of its use in the management of allergic disorders. 2007 Drugs pmid:17335300
Van Overloop H et al. On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase. 2007 Biol. Chem. pmid:17338639
Cui S et al. L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17395449
Roudebush WE Seminal platelet-activating factor. 2007 Semin. Thromb. Hemost. pmid:17253192
Wang S et al. Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. 2007 Chin. Med. J. pmid:17543178
Kulkarni S et al. Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. 2007 Blood pmid:17548580
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Witzenrath M et al. Role of platelet-activating factor in pneumolysin-induced acute lung injury. 2007 Crit. Care Med. pmid:17522574
Keles GC et al. Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. 2007 Clin Oral Investig pmid:17522901
Simonenko VB et al. [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. 2007 Klin Med (Mosk) pmid:17564032
Li Y et al. Autocrine activation of ion currents in the two-cell mouse embryo. 2007 Exp. Cell Res. pmid:17583695
Martin J et al. The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. 2007 Curr. Pharm. Des. pmid:17584105
Ferreira MA et al. Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). 2007 Life Sci. pmid:17588613
Xia SH et al. Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. 2007 World J. Gastroenterol. pmid:17589953
Tosaki T et al. Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. 2007 Biol. Pharm. Bull. pmid:17268064
Zhang X et al. Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. 2007 Neurochem. Res. pmid:17268849
Taheri F and Bazan HE Platelet-activating factor overturns the transcriptional repressor disposition of Sp1 in the expression of MMP-9 in human corneal epithelial cells. 2007 Invest. Ophthalmol. Vis. Sci. pmid:17460244
Dinubile MJ Plasma gelsolin: in search of its raison d'etre. Focus on "Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin". 2007 Am. J. Physiol., Cell Physiol. pmid:17428843
Souza LJ et al. Acute pancreatitis affects non-parenchymal liver cells by a mechanism dependent on platelet-activating factor. 2007 Pancreatology pmid:17449968
Shin CR et al. Differential platelet-activating factor synthesis by monocytes and polymorphonuclear leukocytes from subjects with localized aggressive periodontitis. 2007 J. Periodont. Res. pmid:17451539
Truffinet V et al. No effect of platelet-activating factor on the proliferation and apoptosis of immature forms of leukemic blasts. 2007 Leuk. Res. pmid:17350684
Zhao W et al. [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180114
Paterson WG et al. Role of platelet-activating factor in acid-induced esophageal mucosal injury. 2007 Dig. Dis. Sci. pmid:17415649
Tsimikas S et al. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. 2007 Arterioscler. Thromb. Vasc. Biol. pmid:17626905
Li Y et al. Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo. 2007 Biol. Reprod. pmid:17634444
Nagi-Miura N et al. Involvement of platelet activating factor, histamine and serotonin in acute lethal shock induced by Candida albicans water-soluble extracellular polysaccharide fraction (CAWS) in mice. 2007 Biol. Pharm. Bull. pmid:17603181
Kooyman FN et al. Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. 2007 Infect. Immun. pmid:17606606
Dupré DJ et al. Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. 2007 Cell. Signal. pmid:17609120
Huang QY and Li MJ [Effect of platelet-activating factor on sperm function]. 2007 Zhonghua Nan Ke Xue pmid:17615981
Orr Y et al. Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. 2007 J. Leukoc. Biol. pmid:17675559
Bozlu G et al. Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. 2007 Brain Res. pmid:17320823
Zhou W et al. Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. 2007 Am. J. Physiol. Heart Circ. Physiol. pmid:17322418
Tsutsumi T et al. Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. 2007 Prostaglandins Other Lipid Mediat. pmid:17259070
Viergutz T and Löhrke B Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. 2007 Cell Prolif. pmid:18021181
Chen Q et al. The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. 2007 FEBS Lett. pmid:17996202
Ezoulin MJ et al. A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. 2007 Int. Immunopharmacol. pmid:17996678
Xavier RG et al. Enhanced platelet aggregation and activation under conditions of hypothermia. 2007 Thromb. Haemost. pmid:18064324
Dunkel B et al. Platelet activation in ponies with airway inflammation. 2007 Equine Vet. J. pmid:18065316
Wang J et al. Elevated levels of platelet-monocyte aggregates and related circulating biomarkers in patients with acute coronary syndrome. 2007 Int. J. Cardiol. pmid:16887214
Tsantila N et al. Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. 2007 Mediators Inflamm. pmid:18253466
Li J et al. Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. 2007 Int. J. Neuropsychopharmacol. pmid:16426477
Bock J et al. Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. 2007 World J. Gastroenterol. pmid:17876892
Ryan SD et al. Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. 2007 J. Neurochem. pmid:17877634
Madsen NJ et al. Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. 2007 Am. J. Cardiol. pmid:17697836
Tsoupras AB et al. Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. 2007 Mediators Inflamm. pmid:17710109
Melnikova V and Bar-Eli M Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. 2007 Cancer Metastasis Rev. pmid:17721743
Lo GK et al. What is the potential for overdiagnosis of heparin-induced thrombocytopenia? 2007 Am. J. Hematol. pmid:17722079
Chen J et al. Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. 2007 J. Lipid Res. pmid:17693621
Takahashi T et al. Neutrophil-activating activity and platelet-activating factor synthesis in cytokine-stimulated endothelial cells: reduced activity in growth-arrested cells. 2007 Microvasc. Res. pmid:17027041
Kuckleburg CJ et al. Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. 2007 Infect. Immun. pmid:17118985
Ibe BO et al. Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. 2007 J. Pharmacol. Exp. Ther. pmid:17085546
Saluk-Juszczak J et al. The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. 2007 Curr. Microbiol. pmid:17160361
Huang GD et al. [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. 2007 Zhong Yao Cai pmid:18422199
El Behi M et al. Changes in self-reactive IgG antibody repertoire after treatment of experimental autoimmune encephalomyelitis with anti-allergic drugs. 2007 J. Neuroimmunol. pmid:17097744
Shindou H et al. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. 2007 J. Biol. Chem. pmid:17182612
Ko HM et al. Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis. 2007 Int. J. Cancer pmid:17187368
Bate C et al. Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage. 2007 J Neuroinflammation pmid:17233902
Caini P et al. Modifications of plasma platelet-activating factor (PAF)-acetylhydrolase/PAF system activity in patients with chronic hepatitis C virus infection. 2007 J. Viral Hepat. pmid:17212640
Callender HL et al. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. 2007 Anal. Chem. pmid:17194150
Heusler P and Boehmer G Platelet-activating factor contributes to the induction of long-term potentiation in the rat somatosensory cortex in vitro. 2007 Brain Res. pmid:17196945
Fragopoulou E et al. Biological activity of acetylated phenolic compounds. 2007 J. Agric. Food Chem. pmid:17199317
Greinacher A Too many hits in HIT? 2007 Am. J. Hematol. pmid:17729242
Gui C et al. Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. 2007 Proteins pmid:17243151
Ali A et al. Essential role of platelet-activating factor in male reproduction: a review. 2007 Reprod. Biomed. Online pmid:17298732