Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Grigoriadis G and Stewart AG Human monocytes maintained in culture acquire functional responsiveness to platelet-activating factor that is independent of increases in protein tyrosine phosphorylation. 1997 Clin. Exp. Pharmacol. Physiol. pmid:9269528
Gaumond F et al. Differential signaling pathways in platelet-activating factor-induced proliferation and interleukin-6 production by rat vascular smooth muscle cells. 1997 J. Cardiovasc. Pharmacol. pmid:9269943
Klouche M et al. Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects. 1997 J. Allergy Clin. Immunol. pmid:9275146
Chen D and Chen W Changes of distribution of platelet activating factor in the lung of rats with hypoxic pulmonary hypertension. 1996 Chin. Med. J. pmid:9275354
Cheng D and Chen W Effects of ginkgolide B on isobaric hypoxic pulmonary hypertension in rats. 1996 Chin. Med. J. pmid:9275375
Ren G and Ye R [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. 1996 Zhonghua Nei Ke Za Zhi pmid:9275622
Yamashita A et al. Acyltransferases and transacylases involved in fatty acid remodeling of phospholipids and metabolism of bioactive lipids in mammalian cells. 1997 J. Biochem. pmid:9276665
Bkaily G et al. The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells. 1997 Mol. Cell. Biochem. pmid:9278244
Kume K and Shimizu T Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. 1997 J. Biol. Chem. pmid:9278453
Oh SO et al. Platelet-activating factor in plasma of patients with sickle cell disease in steady state. 1997 J. Lab. Clin. Med. pmid:9280146
Rodríguez Roisin R [Platelet activating factor and bronchial asthma. Is it relevant?]. 1997 Arch. Bronconeumol. pmid:9280556
Kintner DB et al. Hyperglycemic damage to mitochondrial membranes during cerebral ischemia: amelioration by platelet-activating factor antagonist BN 50739. 1997 J. Neurochem. pmid:9282946
Roudebush WE et al. Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. 1997 Biol. Reprod. pmid:9282993
Xie XQ et al. Differential scanning calorimetry and small angle x-ray diffraction study of the interaction of (R)-PAF, (R)-ET-18-OME and (R)-Lyso-PAF with model membranes. 1997 Life Sci. pmid:9284084
Bastos da Silva M et al. Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. 1997 Zentralbl Veterinarmed A pmid:9284631
Edwards CM et al. Effects of the co-polymer surfactant, Pluronic F-68, on platelet aggregation in human whole blood. 1997 Artif Cells Blood Substit Immobil Biotechnol pmid:9285052
Karzai W and Reinhart K Immune modulation and sepsis. 1997 Int. J. Clin. Pract. pmid:9287265
Partrick DA et al. Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. 1997 Surgery pmid:9288123
Van de Weerdt ML et al. Effect of platelet-activating factor on bovine pulmonary function. 1997 Vet. Rec. pmid:9290195
Partrick DA et al. Lipid mediators up-regulate CD11b and prime for concordant superoxide and elastase release in human neutrophils. 1997 J Trauma pmid:9291376
Bozza PT et al. Eosinophil lipid bodies: specific, inducible intracellular sites for enhanced eicosanoid formation. 1997 J. Exp. Med. pmid:9294145
Perico N et al. Platelet-activating factor mediates angiotensin II-induced proteinuria in isolated perfused rat kidney. 1997 J. Am. Soc. Nephrol. pmid:9294830
Albert DH et al. ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in brown Norway rats. 1997 Inflamm. Res. pmid:9297547
O'Brien JG et al. Effects of tranexamic acid and aprotinin on PAF-induced vascular permeability in normal, thrombocytopenic or neutropenic rats. 1997 Inflamm. Res. pmid:9297553
Stewart A et al. The regulation by phosphorylation of 'priming' of phospholipase A2 activity in the neutrophil model system, differentiated HL60 cells. 1997 Br. J. Pharmacol. pmid:9298523
Manabe H et al. Anti-inflammatory and bronchodilator properties of KF19514, a phosphodiesterase 4 and 1 inhibitor. 1997 Eur. J. Pharmacol. pmid:9298930
Marr KA et al. Effect of antigen challenge on the activation of peripheral blood neutrophils from horses with chronic obstructive pulmonary disease. 1997 May-Jun Res. Vet. Sci. pmid:9300544
Kimura M et al. Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9301630
Herbert JM et al. Pharmacological evidence for the putative existence of two different subtypes of PAF receptors on platelets and leukocytes; studies with yangambin. 1997 J Lipid Mediat Cell Signal pmid:9302650
Bialasiewicz P et al. Altered intracellular calcium signalling after PAF stimulations in polymorphonuclear leukocytes from asthmatic patients. 1997 J Lipid Mediat Cell Signal pmid:9302652
Balsa D et al. Effect of endotoxin and platelet-activating factor on rat vascular permeability: role of vasoactive mediators. 1997 J Lipid Mediat Cell Signal pmid:9302653
Ablett JM et al. Influence of antigen challenge on platelet responsiveness in horses with chronic obstructive pulmonary disease. 1997 Equine Vet. J. pmid:9306066
Oh-ishi S [Analysis of chemical mediators involved in acute inflammatory reaction with the rat pleurisy model]. 1997 Nippon Yakurigaku Zasshi pmid:9306414
Tailor A et al. Dexamethasone inhibits leukocyte emigration in rat mesenteric post-capillary venules: an intravital microscopy study. 1997 J. Leukoc. Biol. pmid:9307068
Cortijo J et al. Pharmacological activity of PF-904 in guinea pig in vivo, and on human bronchus and neutrophils in vitro. 1997 Eur. J. Pharmacol. pmid:9311663
Teixeira MM et al. Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin. 1997 J. Clin. Invest. pmid:9312163
Cepinskas G et al. Transendothelial neutrophil migration. Role of neutrophil-derived proteases and relationship to transendothelial protein movement. 1997 Circ. Res. pmid:9314844
Wan S et al. Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. 1997 Chest pmid:9315800
Nakao A et al. cAMP mediates homologous downregulation of PAF receptor mRNA expression in mesangial cells. 1997 Am. J. Physiol. pmid:9321918
Shimizu T and Mutoh H Structure and regulation of platelet activating factor receptor gene. 1997 Adv. Exp. Med. Biol. pmid:9321953
Mori M et al. Localization of platelet-activating factor receptor in the rat brain. 1997 Adv. Exp. Med. Biol. pmid:9321976
Erickson KL et al. Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. 1997 Adv. Exp. Med. Biol. pmid:9321978
Muguruma K et al. The central role of PAF in necrotizing enterocolitis development. 1997 Adv. Exp. Med. Biol. pmid:9321979
Aoki Y et al. A simple, rapid and specific radioreceptor assay for platelet-activating factor. 1997 Adv. Exp. Med. Biol. pmid:9321990
Si Y et al. The change in plasma PAF activity before and after delivery. 1997 Adv. Exp. Med. Biol. pmid:9322006
Murray J et al. Regulation of neutrophil apoptosis by tumor necrosis factor-alpha: requirement for TNFR55 and TNFR75 for induction of apoptosis in vitro. 1997 Blood pmid:9326245
DeLano FA et al. Attenuation of oxygen free radical formation and tissue injury during experimental inflammation by P-selectin blockade. 1997 Microcirculation pmid:9329011
Weber C and Springer TA Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. 1997 J. Clin. Invest. pmid:9329974
Ohkuni H et al. Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. 1997 Adv. Exp. Med. Biol. pmid:9331745
Knight D et al. Adenosine A3 receptor stimulation inhibits migration of human eosinophils. 1997 J. Leukoc. Biol. pmid:9335316
Getting SJ et al. Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. 1997 J. Pharmacol. Exp. Ther. pmid:9336316
Greiff L et al. Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. 1997 Acta Physiol. Scand. pmid:9338520
Ohashi Y et al. Platelet activating factor compromises airway epithelial defense functions. 1997 J. Allergy Clin. Immunol. pmid:9338547
Hirashima Y et al. Elevation of platelet activating factor, inflammatory cytokines, and coagulation factors in the internal jugular vein of patients with subarachnoid hemorrhage. 1997 Neurochem. Res. pmid:9342729
Francescangeli E et al. Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation. 1997 Neurochem. Res. pmid:9342735
Bastos da Silva M et al. Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. 1997 Sep-Oct Vet. Res. pmid:9342825
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Bastos da Silva MB et al. The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. 1997 Vet. Res. Commun. pmid:9345719
Million M et al. Effects of neuropeptide FF on intestinal motility and temperature changes induced by endotoxin and platelet-activating factor. 1997 Eur. J. Pharmacol. pmid:9346330
Aspey BS et al. Effects of combined glutamate and platelet-activating factor inhibition on the outcome of focal cerebral ischaemia - an initial screening study. 1997 Metab Brain Dis pmid:9346472
Bzeizi KI et al. Primary graft dysfunction after liver transplantation: from pathogenesis to prevention. 1997 Liver Transpl Surg pmid:9346727
Denham W et al. Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis. 1997 Gastroenterology pmid:9352880
Howarth PH Mediators of nasal blockage in allergic rhinitis. 1997 Allergy pmid:9353555
Nagaoka H et al. 2-(3-Pyridyl)thiazolidine-4-carboxamides. 1. Novel orally active antagonists of platelet-activating factor (PAF). 1997 Chem. Pharm. Bull. pmid:9353894
Liu B et al. Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. 1997 Biochem. J. pmid:9355758
Silomon M et al. Role of platelet-activating factor in hepatocellular Ca2+ alterations during hemorrhagic shock. 1997 J. Surg. Res. pmid:9356229
Wang H et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: effect of cycloheximide. 1997 Pediatr. Res. pmid:9357930
May JA et al. Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. 1997 Thromb. Res. pmid:9361371
Radonjic-Lazovic G and Roudebush WE The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. 1995 Early Pregnancy pmid:9363251
Hershkowitz M and Adunsky A Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct dementia patients. 1996 Nov-Dec Neurobiol. Aging pmid:9363797
Kishimoto S et al. Comparison of platelet-activating factor receptor mRNA levels in peripheral blood eosinophils from normal subjects and atopic asthmatic patients. 1997 Int. Arch. Allergy Immunol. pmid:9363928
Manna SK et al. Hamycin inhibits IL-8-induced biologic response by modulating its receptor in human polymorphonuclear neutrophils. 1997 J. Immunol. pmid:9366432
Saeed SA et al. Anti-thrombotic and anti-inflammatory activities of protopine. 1997 Pharmacol. Res. pmid:9368908
Snyder F CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor. 1997 Biochim. Biophys. Acta pmid:9370322
Nagase T et al. Airway responsiveness in transgenic mice overexpressing platelet-activating factor receptor. Roles of thromboxanes and leukotrienes. 1997 Am. J. Respir. Crit. Care Med. pmid:9372685
Tetta C et al. Relevance of platelet-activating factor in inflammation and sepsis: mechanisms and kinetics of removal in extracorporeal treatments. 1997 Am. J. Kidney Dis. pmid:9372980
Garland A et al. Activated eosinophils elicit substance P release from cultured dorsal root ganglion neurons. 1997 Am. J. Physiol. pmid:9374740
Miyahara T et al. Role of circulating blood components and thromboxane in anaphylactic vasoconstriction in isolated canine lungs. 1997 J. Appl. Physiol. pmid:9375313
Bazan HE et al. Platelet-activating factor induces cyclooxygenase-2 gene expression in corneal epithelium. Requirement of calcium in the signal transduction pathway. 1997 Invest. Ophthalmol. Vis. Sci. pmid:9375567
Mori M et al. Localization of platelet-activating factor receptor messenger RNA in the rat eye. 1997 Invest. Ophthalmol. Vis. Sci. pmid:9375587
Okada S et al. Migration of eosinophils through basement membrane components in vitro: role of matrix metalloproteinase-9. 1997 Am. J. Respir. Cell Mol. Biol. pmid:9376127
Mantovani A The interplay between primary and secondary cytokines. Cytokines involved in the regulation of monocyte recruitment. 1997 Drugs pmid:9378074
Kagoshima M et al. Effect of Y-24180, a long-acting antagonist to platelet-activating factor (PAF), on PAF-induced reactions: a relationship between the partial structure of the compound and its duration of the action. 1997 Pharmacology pmid:9380772
Kozai T et al. Platelet activating factor causes hyperconstriction at the inflammatory coronary lesions in pigs in vivo. 1997 Coron. Artery Dis. pmid:9383603
Wang HG et al. Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9384519
Sapir T et al. Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit. 1997 EMBO J. pmid:9384577
Yu P et al. [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. 1996 Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi pmid:9387456
Zhou X et al. [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. 1996 Zhonghua Jie He He Hu Xi Za Zhi pmid:9387483
Cheng D et al. [The level of platelet activating factor in blood of rats with hypoxic pulmonary hypertension]. 1996 Hua Xi Yi Ke Da Xue Xue Bao pmid:9389027
Cheng D and Chen W [The role of platelet activating factor in chronic pulmonary hypertension]. 1996 Hua Xi Yi Ke Da Xue Xue Bao pmid:9389061
Hu DH and Ma CT [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. 1996 Sheng Li Xue Bao pmid:9389196
Bellamy MC et al. Changes in inflammatory mediators during orthotopic liver transplantation. 1997 Br J Anaesth pmid:9389852
Nathan N et al. Cytokine and lipid mediator blood concentrations after coronary artery surgery. 1997 Anesth. Analg. pmid:9390587
Im SY et al. Involvement of nuclear factor-kappa B in platelet-activating factor-mediated tumor necrosis factor-alpha expression. 1997 Eur. J. Immunol. pmid:9394802
Negro Alvarez JM et al. Platelet-activating factor antagonists. 1997 Sep-Oct Allergol Immunopathol (Madr) pmid:9395010
Elzi DJ et al. Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. 1997 Biochem. Biophys. Res. Commun. pmid:9398641
el-Shazly AE et al. Mechanisms involved in activation of human eosinophil exocytosis by substance P: an in vitro model of sensory neuroimmunomodulation. 1997 Aug-Dec Immunol. Invest. pmid:9399104
Erickson KL et al. Induction and modulation of macrophage Ia antigen expression by platelet-activating factor. 1997 J. Leukoc. Biol. pmid:9400826
Bix GJ and Clark GD Elvax as a slow-release delivery agent for a platelet-activating factor receptor agonist and antagonist. 1997 J. Neurosci. Methods pmid:9402559